The ABACHAI clinical trial protocol: Safety and efficacy of abatacept (s.c.) in patients with CTLA-4 insufficiency or LRBA deficiency: A non controlled phase 2 clinical trial

The ABACHAI clinical trial protocol: Safety and efficacy of abatacept (s.c.) in patients with CTLA-4 insufficiency or LRBA deficiency: A non controlled phase 2 clinical trial

Background: Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) insufficiency and lipopolysaccharide-responsive and beige-like anchor protein (LRBA) deficiency are both complex immune dysregulation syndromes with an underlying regulatory T cell dysfunction due to the lack of CTLA-4 protein. As anti...

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Bibliographic Details
Main Authors: Máté Krausz, Annette Uhlmann, Ina Caroline Rump, Gabriele Ihorst, Sigune Goldacker, Georgios Sogkas, Sara Posadas-Cantera, Reinhold Schmidt, Manuel Feißt, Laia Alsina, Ingunn Dybedal, Mike Recher, Klaus Warnatz, Bodo Grimbacher
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Contemporary Clinical Trials Communications
Subjects:
CTLA-4 insufficiency
LRBA deficiency
abatacept
Clinical trial protocol
Disease severity score
Immunodeficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865422001259

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