Antihyperlipidemic and antioxidant properties of hydro-alcoholic extracts from Anogeissus leiocarpus (Combretaceae)
Anogeissus leiocarpus (Combretaceae) is a medicinal plant used in Togo to treat diabetes mellitus and others diseases. The present study was undertaken to evaluate the antihyperlipidemic and antioxidant activities of total extract and fractions of roots of Anogeissus leiocarpus.The antihyperlipidemi...
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Elsevier
2021-04-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844021007519 |
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| author | Aku Enam Motto Povi Lawson-Evi Batomayena Bakoma Kwashie Eklu-Gadegbeku Kodjo Aklikokou |
| author_facet | Aku Enam Motto Povi Lawson-Evi Batomayena Bakoma Kwashie Eklu-Gadegbeku Kodjo Aklikokou |
| author_sort | Aku Enam Motto |
| collection | DOAJ |
| description | Anogeissus leiocarpus (Combretaceae) is a medicinal plant used in Togo to treat diabetes mellitus and others diseases. The present study was undertaken to evaluate the antihyperlipidemic and antioxidant activities of total extract and fractions of roots of Anogeissus leiocarpus.The antihyperlipidemic activity of the total extract and the supernatant was performed in vivo by the fructose overload test in ICR mice. Antioxidant potential was determined in vitro by methods based on scavenging of DPPH∗, total antioxidant capacity and reducing power. After the screening, phenolic compounds and flavonoids were evaluated by the well–known colorimetric assay using respectively Folin–Ciocalteu reagent and aluminium chloride.The results obtained showed that the total extract and the supernatant significantly reduced the serum and liver levels of triglycerides and hence the level of VLDL-Cholesterol compared to hyperlipidemic mice. In vitro the total extract and fractions had the ability to scavenge free radicals, to reduce metal and possessed strong total antioxidant activity. Phytochemical screening revealed the presence of polyphenols, flavonoids, alkaloids, tannins and saponosides in the extract and fractions. And the supernatant fraction contained more polyphenolic compounds than others.From this study, it is concluded that the total extract and fraction of Anogeissus leiocarpus possessed strong antihyperlipidemic, antioxidant properties and were riched in polyphenols, which can be used in the treatment of diabetes mellitus’ complications. Hence, the supernatant fraction was the most biologically active. |
| first_indexed | 2024-12-17T20:12:03Z |
| format | Article |
| id | doaj.art-5c6c57a17d9a4215a6e27dbbaa7ec75e |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-17T20:12:03Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-5c6c57a17d9a4215a6e27dbbaa7ec75e2022-12-21T21:34:13ZengElsevierHeliyon2405-84402021-04-0174e06648Antihyperlipidemic and antioxidant properties of hydro-alcoholic extracts from Anogeissus leiocarpus (Combretaceae)Aku Enam Motto0Povi Lawson-Evi1Batomayena Bakoma2Kwashie Eklu-Gadegbeku3Kodjo Aklikokou4Laboratory of Physiology/Pharmacology, Faculty of Sciences, University of Lome, BP 1515, Togo; Corresponding author.Laboratory of Physiology/Pharmacology, Faculty of Sciences, University of Lome, BP 1515, TogoDepartment of Pharmacognosy, Faculty of Health Sciences, University of Lome, BP 1515, TogoLaboratory of Physiology/Pharmacology, Faculty of Sciences, University of Lome, BP 1515, TogoLaboratory of Physiology/Pharmacology, Faculty of Sciences, University of Lome, BP 1515, TogoAnogeissus leiocarpus (Combretaceae) is a medicinal plant used in Togo to treat diabetes mellitus and others diseases. The present study was undertaken to evaluate the antihyperlipidemic and antioxidant activities of total extract and fractions of roots of Anogeissus leiocarpus.The antihyperlipidemic activity of the total extract and the supernatant was performed in vivo by the fructose overload test in ICR mice. Antioxidant potential was determined in vitro by methods based on scavenging of DPPH∗, total antioxidant capacity and reducing power. After the screening, phenolic compounds and flavonoids were evaluated by the well–known colorimetric assay using respectively Folin–Ciocalteu reagent and aluminium chloride.The results obtained showed that the total extract and the supernatant significantly reduced the serum and liver levels of triglycerides and hence the level of VLDL-Cholesterol compared to hyperlipidemic mice. In vitro the total extract and fractions had the ability to scavenge free radicals, to reduce metal and possessed strong total antioxidant activity. Phytochemical screening revealed the presence of polyphenols, flavonoids, alkaloids, tannins and saponosides in the extract and fractions. And the supernatant fraction contained more polyphenolic compounds than others.From this study, it is concluded that the total extract and fraction of Anogeissus leiocarpus possessed strong antihyperlipidemic, antioxidant properties and were riched in polyphenols, which can be used in the treatment of diabetes mellitus’ complications. Hence, the supernatant fraction was the most biologically active.http://www.sciencedirect.com/science/article/pii/S2405844021007519Anogeissus leiocarpusSupernatantAntihyperlipidemicAntioxidantPolyphenols |
| spellingShingle | Aku Enam Motto Povi Lawson-Evi Batomayena Bakoma Kwashie Eklu-Gadegbeku Kodjo Aklikokou Antihyperlipidemic and antioxidant properties of hydro-alcoholic extracts from Anogeissus leiocarpus (Combretaceae) Heliyon Anogeissus leiocarpus Supernatant Antihyperlipidemic Antioxidant Polyphenols |
| title | Antihyperlipidemic and antioxidant properties of hydro-alcoholic extracts from Anogeissus leiocarpus (Combretaceae) |
| title_full | Antihyperlipidemic and antioxidant properties of hydro-alcoholic extracts from Anogeissus leiocarpus (Combretaceae) |
| title_fullStr | Antihyperlipidemic and antioxidant properties of hydro-alcoholic extracts from Anogeissus leiocarpus (Combretaceae) |
| title_full_unstemmed | Antihyperlipidemic and antioxidant properties of hydro-alcoholic extracts from Anogeissus leiocarpus (Combretaceae) |
| title_short | Antihyperlipidemic and antioxidant properties of hydro-alcoholic extracts from Anogeissus leiocarpus (Combretaceae) |
| title_sort | antihyperlipidemic and antioxidant properties of hydro alcoholic extracts from anogeissus leiocarpus combretaceae |
| topic | Anogeissus leiocarpus Supernatant Antihyperlipidemic Antioxidant Polyphenols |
| url | http://www.sciencedirect.com/science/article/pii/S2405844021007519 |
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