Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice
One purified neutral polysaccharide fraction was obtained from the rhizome of Polygonatum sibiricum by DEAE ion exchange and gel chromatography. Structure elucidation was performed by methanolysis, methylation, FT-IR, and NMR. The results indicated that PSP-NP was composed of 1,4-β-D-Gal,1, 4, 6-β-D...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.992102/full |
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| author | Li-Xia Li Xin Feng Meng-Ting Tao Berit Smestad Paulsen Chao Huang Bin Feng Wei Liu Zhong-Qiong Yin Xu Song Xinghong Zhao Xiao-Xia Liang Li-Zi Yin Hua-Qiao Tang Yuan-Feng Zou |
| author_facet | Li-Xia Li Xin Feng Meng-Ting Tao Berit Smestad Paulsen Chao Huang Bin Feng Wei Liu Zhong-Qiong Yin Xu Song Xinghong Zhao Xiao-Xia Liang Li-Zi Yin Hua-Qiao Tang Yuan-Feng Zou |
| author_sort | Li-Xia Li |
| collection | DOAJ |
| description | One purified neutral polysaccharide fraction was obtained from the rhizome of Polygonatum sibiricum by DEAE ion exchange and gel chromatography. Structure elucidation was performed by methanolysis, methylation, FT-IR, and NMR. The results indicated that PSP-NP was composed of 1,4-β-D-Gal,1, 4, 6-β-D-Gal, T-α-D-Man,1, 4-α-D-Glc, and T-α-D-Glc with a molecular weight of 43.0 kDa. We supplied this polysaccharide to aged mice and found it is of benefits to intestinal functions, as indicated by better tissue integrity and motility, improved oxidative stress and inflammation, reduced intestinal permeability and serum LPS level, as well as balanced gut microbial composition and short-chain fatty acids production. These results display a novel Polygonatum sibiricum polysaccharide to improve the intestinal function of aged mice, which provides pieces of evidence for its further development and utilization. |
| first_indexed | 2024-04-11T10:00:29Z |
| format | Article |
| id | doaj.art-5c6e166203814b968c11e038a49413a3 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T10:00:29Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-5c6e166203814b968c11e038a49413a32022-12-22T04:30:25ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-09-01910.3389/fnut.2022.992102992102Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged miceLi-Xia Li0Xin Feng1Meng-Ting Tao2Berit Smestad Paulsen3Chao Huang4Bin Feng5Wei Liu6Zhong-Qiong Yin7Xu Song8Xinghong Zhao9Xiao-Xia Liang10Li-Zi Yin11Hua-Qiao Tang12Yuan-Feng Zou13Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaDepartment of Pharmacy, Section Pharmaceutical Chemistry, Area Pharmacognosy, University of Oslo, Oslo, NorwayLaboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of the Ministry of Education for the Standardization of Traditional Chinese Medicine, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaNatural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaOne purified neutral polysaccharide fraction was obtained from the rhizome of Polygonatum sibiricum by DEAE ion exchange and gel chromatography. Structure elucidation was performed by methanolysis, methylation, FT-IR, and NMR. The results indicated that PSP-NP was composed of 1,4-β-D-Gal,1, 4, 6-β-D-Gal, T-α-D-Man,1, 4-α-D-Glc, and T-α-D-Glc with a molecular weight of 43.0 kDa. We supplied this polysaccharide to aged mice and found it is of benefits to intestinal functions, as indicated by better tissue integrity and motility, improved oxidative stress and inflammation, reduced intestinal permeability and serum LPS level, as well as balanced gut microbial composition and short-chain fatty acids production. These results display a novel Polygonatum sibiricum polysaccharide to improve the intestinal function of aged mice, which provides pieces of evidence for its further development and utilization.https://www.frontiersin.org/articles/10.3389/fnut.2022.992102/fullheteropolysaccharidePolygonatum sibiricumanti-agingjejunumcolon |
| spellingShingle | Li-Xia Li Xin Feng Meng-Ting Tao Berit Smestad Paulsen Chao Huang Bin Feng Wei Liu Zhong-Qiong Yin Xu Song Xinghong Zhao Xiao-Xia Liang Li-Zi Yin Hua-Qiao Tang Yuan-Feng Zou Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice Frontiers in Nutrition heteropolysaccharide Polygonatum sibiricum anti-aging jejunum colon |
| title | Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice |
| title_full | Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice |
| title_fullStr | Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice |
| title_full_unstemmed | Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice |
| title_short | Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice |
| title_sort | benefits of neutral polysaccharide from rhizomes of polygonatum sibiricum to intestinal function of aged mice |
| topic | heteropolysaccharide Polygonatum sibiricum anti-aging jejunum colon |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.992102/full |
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