Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis
Peritoneal metastasis is one of the most common forms of death for gastrointestinal cancers, however, its cell composition is incompletely understood. Here, the authors use single cell RNA-seq of peritoneal metastases from 35 patients and show diversity in immune cells, and plasticity in cancer cell...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36310-9 |
| _version_ | 1797864143295873024 |
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| author | Xuan-Zhang Huang Min-Jiao Pang Jia-Yi Li Han-Yu Chen Jing-Xu Sun Yong-Xi Song Hong-Jie Ni Shi-Yu Ye Shi Bai Teng-Hui Li Xin-Yu Wang Jing-Yuan Lu Jin-Jia Yang Xun Sun Jason C. Mills Zhi-Feng Miao Zhen-Ning Wang |
| author_facet | Xuan-Zhang Huang Min-Jiao Pang Jia-Yi Li Han-Yu Chen Jing-Xu Sun Yong-Xi Song Hong-Jie Ni Shi-Yu Ye Shi Bai Teng-Hui Li Xin-Yu Wang Jing-Yuan Lu Jin-Jia Yang Xun Sun Jason C. Mills Zhi-Feng Miao Zhen-Ning Wang |
| author_sort | Xuan-Zhang Huang |
| collection | DOAJ |
| description | Peritoneal metastasis is one of the most common forms of death for gastrointestinal cancers, however, its cell composition is incompletely understood. Here, the authors use single cell RNA-seq of peritoneal metastases from 35 patients and show diversity in immune cells, and plasticity in cancer cell phenotypes and autophagy related genes as biomarkers of prognosis. |
| first_indexed | 2024-04-09T22:46:55Z |
| format | Article |
| id | doaj.art-5c6eefec46af44fd9a4f6e14eaea798c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:46:55Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5c6eefec46af44fd9a4f6e14eaea798c2023-03-22T11:46:46ZengNature PortfolioNature Communications2041-17232023-02-0114112210.1038/s41467-023-36310-9Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasisXuan-Zhang Huang0Min-Jiao Pang1Jia-Yi Li2Han-Yu Chen3Jing-Xu Sun4Yong-Xi Song5Hong-Jie Ni6Shi-Yu Ye7Shi Bai8Teng-Hui Li9Xin-Yu Wang10Jing-Yuan Lu11Jin-Jia Yang12Xun Sun13Jason C. Mills14Zhi-Feng Miao15Zhen-Ning Wang16Department of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityEight-year system, Institute of innovation, China Medical University, Shenyang, Liaoning provinceEight-year system, Institute of innovation, China Medical University, Shenyang, Liaoning provinceDepartment of Immunology, China Medical UniversitySection of Gastroenterology & Hepatology, Department of Medicine, Baylor College of MedicineDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical UniversityPeritoneal metastasis is one of the most common forms of death for gastrointestinal cancers, however, its cell composition is incompletely understood. Here, the authors use single cell RNA-seq of peritoneal metastases from 35 patients and show diversity in immune cells, and plasticity in cancer cell phenotypes and autophagy related genes as biomarkers of prognosis.https://doi.org/10.1038/s41467-023-36310-9 |
| spellingShingle | Xuan-Zhang Huang Min-Jiao Pang Jia-Yi Li Han-Yu Chen Jing-Xu Sun Yong-Xi Song Hong-Jie Ni Shi-Yu Ye Shi Bai Teng-Hui Li Xin-Yu Wang Jing-Yuan Lu Jin-Jia Yang Xun Sun Jason C. Mills Zhi-Feng Miao Zhen-Ning Wang Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis Nature Communications |
| title | Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis |
| title_full | Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis |
| title_fullStr | Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis |
| title_full_unstemmed | Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis |
| title_short | Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis |
| title_sort | single cell sequencing of ascites fluid illustrates heterogeneity and therapy induced evolution during gastric cancer peritoneal metastasis |
| url | https://doi.org/10.1038/s41467-023-36310-9 |
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