The Efficacy of Evening Primrose in Rheumatoid Arthritis: a Systematic Review
Considering the different side effects of the long-time conventional anti-rheumatic drugs prescribed for the treatment of rheumatoid arthritis, numerous studies have focused on herbal medicines to reduce inflammation in autoimmune diseases. Although the beneficial properties of evening primrose on r...
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| Format: | Article |
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Iranian Society of Pharmacognosy
2024-04-01
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| Series: | Research Journal of Pharmacognosy |
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| Online Access: | https://www.rjpharmacognosy.ir/article_187249_01da58b7b034af92c4bb782647b45f62.pdf |
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| author | Mehri Hajiaghayi Amir Hossein Dolati-Somarin Fatemeh Gholizadeh Bahareh Abd-Nikfarjam* |
| author_facet | Mehri Hajiaghayi Amir Hossein Dolati-Somarin Fatemeh Gholizadeh Bahareh Abd-Nikfarjam* |
| author_sort | Mehri Hajiaghayi |
| collection | DOAJ |
| description | Considering the different side effects of the long-time conventional anti-rheumatic drugs prescribed for the treatment of rheumatoid arthritis, numerous studies have focused on herbal medicines to reduce inflammation in autoimmune diseases. Although the beneficial properties of evening primrose on rheumatoid arthritis have been determined, the results of the studies have not been systematically reported. The present review has investigated the effects of evening primrose on rheumatoid arthritis systematically. We searched the following electronic databases until March 2023: PubMed, the Cochrane Library, the China National Knowledge Infrastructure, Scopus, ProQuest, Google Scholar electronic databases, allied and complementary medicine database (AMED), and scientific information database (SID) databases for relevant studies. We excluded non-English articles and those not meeting our criteria. We chose all of the correlated original clinical, animal, and in vitro studies. Each article was assessed critically for the possible risk of bias. Thirteen articles were analyzed. Animal and in vitro research confirmed the desired effects of evening primrose on clinical, inflammatory, oxidative, and immunologic factors in rheumatoid arthritis. Also, the results of clinical studies showed the change and improvement of inflammatory and oxidative biomarkers in rheumatoid arthritis. Evening primrose could control rheumatoid arthritis in multiple ways such as decreasing inflammation, inhibiting oxidative stress, and modulating the immune system. This article provides convincing evidence to support the efficacy of evening primrose in rheumatoid arthritis and explains the significance of future clinical trials. Further large-scale high-quality randomized controlled trials (RCTs) assessing the efficacy of evening primrose on rheumatoid arthritis as a primary outcome variable are recommended. |
| first_indexed | 2024-04-24T08:54:16Z |
| format | Article |
| id | doaj.art-5c703499473246bd9cb83be2fa44e401 |
| institution | Directory Open Access Journal |
| issn | 2345-4458 2345-5977 |
| language | English |
| last_indexed | 2024-04-24T08:54:16Z |
| publishDate | 2024-04-01 |
| publisher | Iranian Society of Pharmacognosy |
| record_format | Article |
| series | Research Journal of Pharmacognosy |
| spelling | doaj.art-5c703499473246bd9cb83be2fa44e4012024-04-16T08:34:23ZengIranian Society of PharmacognosyResearch Journal of Pharmacognosy2345-44582345-59772024-04-01112717910.22127/rjp.2023.414090.2212187249The Efficacy of Evening Primrose in Rheumatoid Arthritis: a Systematic ReviewMehri Hajiaghayi0Amir Hossein Dolati-Somarin1Fatemeh Gholizadeh2Bahareh Abd-Nikfarjam*3Department of Biology, Concordia University, Montreal, Canada.Department of Immunology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Biology, Concordia University, Montreal, Canada.Department of Immunology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.Considering the different side effects of the long-time conventional anti-rheumatic drugs prescribed for the treatment of rheumatoid arthritis, numerous studies have focused on herbal medicines to reduce inflammation in autoimmune diseases. Although the beneficial properties of evening primrose on rheumatoid arthritis have been determined, the results of the studies have not been systematically reported. The present review has investigated the effects of evening primrose on rheumatoid arthritis systematically. We searched the following electronic databases until March 2023: PubMed, the Cochrane Library, the China National Knowledge Infrastructure, Scopus, ProQuest, Google Scholar electronic databases, allied and complementary medicine database (AMED), and scientific information database (SID) databases for relevant studies. We excluded non-English articles and those not meeting our criteria. We chose all of the correlated original clinical, animal, and in vitro studies. Each article was assessed critically for the possible risk of bias. Thirteen articles were analyzed. Animal and in vitro research confirmed the desired effects of evening primrose on clinical, inflammatory, oxidative, and immunologic factors in rheumatoid arthritis. Also, the results of clinical studies showed the change and improvement of inflammatory and oxidative biomarkers in rheumatoid arthritis. Evening primrose could control rheumatoid arthritis in multiple ways such as decreasing inflammation, inhibiting oxidative stress, and modulating the immune system. This article provides convincing evidence to support the efficacy of evening primrose in rheumatoid arthritis and explains the significance of future clinical trials. Further large-scale high-quality randomized controlled trials (RCTs) assessing the efficacy of evening primrose on rheumatoid arthritis as a primary outcome variable are recommended.https://www.rjpharmacognosy.ir/article_187249_01da58b7b034af92c4bb782647b45f62.pdfevening primroseoenothera biennisonagraceaeratrheumatoid arthritis |
| spellingShingle | Mehri Hajiaghayi Amir Hossein Dolati-Somarin Fatemeh Gholizadeh Bahareh Abd-Nikfarjam* The Efficacy of Evening Primrose in Rheumatoid Arthritis: a Systematic Review Research Journal of Pharmacognosy evening primrose oenothera biennis onagraceae rat rheumatoid arthritis |
| title | The Efficacy of Evening Primrose in Rheumatoid Arthritis: a Systematic Review |
| title_full | The Efficacy of Evening Primrose in Rheumatoid Arthritis: a Systematic Review |
| title_fullStr | The Efficacy of Evening Primrose in Rheumatoid Arthritis: a Systematic Review |
| title_full_unstemmed | The Efficacy of Evening Primrose in Rheumatoid Arthritis: a Systematic Review |
| title_short | The Efficacy of Evening Primrose in Rheumatoid Arthritis: a Systematic Review |
| title_sort | efficacy of evening primrose in rheumatoid arthritis a systematic review |
| topic | evening primrose oenothera biennis onagraceae rat rheumatoid arthritis |
| url | https://www.rjpharmacognosy.ir/article_187249_01da58b7b034af92c4bb782647b45f62.pdf |
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