Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy

Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy

Abstract Missense variants ABI3_rs616338-T and PLCG2_rs72824905-G were previously associated with elevated or reduced risk of Alzheimer’s disease (AD), respectively. Despite reports of associations with other neurodegenerative diseases, there are few studies of these variants in purely neuropatholog...

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Bibliographic Details
Main Authors: Samantha L. Strickland, Hélène Morel, Christian Prusinski, Mariet Allen, Tulsi A. Patel, Minerva M. Carrasquillo, Olivia J. Conway, Sarah J. Lincoln, Joseph S. Reddy, Thuy Nguyen, Kimberly G. Malphrus, Alexandra I. Soto, Ronald L. Walton, Julia E. Crook, Melissa E. Murray, Bradley F. Boeve, Ronald C. Petersen, John A. Lucas, Tanis J. Ferman, Ryan J. Uitti, Zbigniew K. Wszolek, Owen A. Ross, Neill R. Graff-Radford, Dennis W. Dickson, Nilüfer Ertekin-Taner
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Acta Neuropathologica Communications
Subjects:
Lewy body disease
Dementia with Lewy bodies
Progressive supranuclear palsy
Neuropathology
Tau
Amyloid ß
Online Access:http://link.springer.com/article/10.1186/s40478-020-01050-0

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