Single Point Insulin Sensitivity Estimator (SPISE) As a Prognostic Marker for Emerging Dysglycemia in Children with Overweight or Obesity
The single point insulin sensitivity estimator (SPISE) is a recently developed fasting index for insulin sensitivity based on triglycerides, high density lipoprotein cholesterol, and body mass index. SPISE has been validated in juveniles and adults; still, its role during childhood remains unclear....
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/13/1/100 |
| _version_ | 1797438796213518336 |
|---|---|
| author | Robert Stein Florian Koutny Johannes Riedel Natascha Dörr Klara Meyer Marco Colombo Mandy Vogel Christian Heinz Anderwald Matthias Blüher Wieland Kiess Antje Körner Daniel Weghuber |
| author_facet | Robert Stein Florian Koutny Johannes Riedel Natascha Dörr Klara Meyer Marco Colombo Mandy Vogel Christian Heinz Anderwald Matthias Blüher Wieland Kiess Antje Körner Daniel Weghuber |
| author_sort | Robert Stein |
| collection | DOAJ |
| description | The single point insulin sensitivity estimator (SPISE) is a recently developed fasting index for insulin sensitivity based on triglycerides, high density lipoprotein cholesterol, and body mass index. SPISE has been validated in juveniles and adults; still, its role during childhood remains unclear. To evaluate the age- and sex-specific distribution of SPISE, its correlation with established fasting indexes and its application as a prognostic marker for future dysglycemia during childhood and adolescence were assessed. We performed linear modeling and correlation analyses on a cross-sectional cohort of 2107 children and adolescents (age 5 to 18.4 years) with overweight or obesity. Furthermore, survival analyses were conducted upon a longitudinal cohort of 591 children with overweight/obesity (1712 observations) with a maximum follow-up time of nearly 20 years, targeting prediabetes/dysglycemia as the end point. The SPISE index decreased significantly with age (−0.34 units per year, <i>p</i> < 0.001) among children and adolescents with overweight and obesity. Sex did not have an influence on SPISE. There was a modest correlation between SPISE and established fasting markers of insulin resistance (R = −0.49 for HOMA-IR, R = −0.55 for QUICKI-IR). SPISE is a better prognostic marker for future dysglycemia (hazard ratio (HR) 3.47, 95% confidence interval (CI) 1.60–7.51, <i>p</i> < 0.01) than HOMA-IR and QUICKI-IR (HR 2.44, 95% CI 1.24–4.81, <i>p</i> < 0.05). The SPISE index is a surrogate marker for insulin resistance predicting emerging dysglycemia in children with overweight or obesity, and could, therefore, be applied to pediatric cohorts that lack direct insulin assessment. |
| first_indexed | 2024-03-09T11:42:27Z |
| format | Article |
| id | doaj.art-5c7182960eca4ebbaa8c7c104a85efc5 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T11:42:27Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-5c7182960eca4ebbaa8c7c104a85efc52023-11-30T23:28:59ZengMDPI AGMetabolites2218-19892023-01-0113110010.3390/metabo13010100Single Point Insulin Sensitivity Estimator (SPISE) As a Prognostic Marker for Emerging Dysglycemia in Children with Overweight or ObesityRobert Stein0Florian Koutny1Johannes Riedel2Natascha Dörr3Klara Meyer4Marco Colombo5Mandy Vogel6Christian Heinz Anderwald7Matthias Blüher8Wieland Kiess9Antje Körner10Daniel Weghuber11Center for Pediatric Research, University Hospital for Children and Adolescents, Medical Faculty, University of Leipzig, 04103 Leipzig, GermanyDepartment of Pediatrics, Paracelsus Private Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, AustriaCenter for Pediatric Research, University Hospital for Children and Adolescents, Medical Faculty, University of Leipzig, 04103 Leipzig, GermanyCenter for Pediatric Research, University Hospital for Children and Adolescents, Medical Faculty, University of Leipzig, 04103 Leipzig, GermanyCenter for Pediatric Research, University Hospital for Children and Adolescents, Medical Faculty, University of Leipzig, 04103 Leipzig, GermanyCenter for Pediatric Research, University Hospital for Children and Adolescents, Medical Faculty, University of Leipzig, 04103 Leipzig, GermanyLeipzig Research Center for Civilization Diseases (LIFE Child), Medical Faculty, University of Leipzig, 04103 Leipzig, GermanyDepartment of Pediatrics, Paracelsus Private Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, AustriaHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), University Hospital Leipzig, 04103 Leipzig, GermanyCenter for Pediatric Research, University Hospital for Children and Adolescents, Medical Faculty, University of Leipzig, 04103 Leipzig, GermanyCenter for Pediatric Research, University Hospital for Children and Adolescents, Medical Faculty, University of Leipzig, 04103 Leipzig, GermanyDepartment of Pediatrics, Paracelsus Private Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, AustriaThe single point insulin sensitivity estimator (SPISE) is a recently developed fasting index for insulin sensitivity based on triglycerides, high density lipoprotein cholesterol, and body mass index. SPISE has been validated in juveniles and adults; still, its role during childhood remains unclear. To evaluate the age- and sex-specific distribution of SPISE, its correlation with established fasting indexes and its application as a prognostic marker for future dysglycemia during childhood and adolescence were assessed. We performed linear modeling and correlation analyses on a cross-sectional cohort of 2107 children and adolescents (age 5 to 18.4 years) with overweight or obesity. Furthermore, survival analyses were conducted upon a longitudinal cohort of 591 children with overweight/obesity (1712 observations) with a maximum follow-up time of nearly 20 years, targeting prediabetes/dysglycemia as the end point. The SPISE index decreased significantly with age (−0.34 units per year, <i>p</i> < 0.001) among children and adolescents with overweight and obesity. Sex did not have an influence on SPISE. There was a modest correlation between SPISE and established fasting markers of insulin resistance (R = −0.49 for HOMA-IR, R = −0.55 for QUICKI-IR). SPISE is a better prognostic marker for future dysglycemia (hazard ratio (HR) 3.47, 95% confidence interval (CI) 1.60–7.51, <i>p</i> < 0.01) than HOMA-IR and QUICKI-IR (HR 2.44, 95% CI 1.24–4.81, <i>p</i> < 0.05). The SPISE index is a surrogate marker for insulin resistance predicting emerging dysglycemia in children with overweight or obesity, and could, therefore, be applied to pediatric cohorts that lack direct insulin assessment.https://www.mdpi.com/2218-1989/13/1/100SPISEchildhood obesitydysglycemiaearly-onset diabetesprediabetestype 2 diabetes |
| spellingShingle | Robert Stein Florian Koutny Johannes Riedel Natascha Dörr Klara Meyer Marco Colombo Mandy Vogel Christian Heinz Anderwald Matthias Blüher Wieland Kiess Antje Körner Daniel Weghuber Single Point Insulin Sensitivity Estimator (SPISE) As a Prognostic Marker for Emerging Dysglycemia in Children with Overweight or Obesity Metabolites SPISE childhood obesity dysglycemia early-onset diabetes prediabetes type 2 diabetes |
| title | Single Point Insulin Sensitivity Estimator (SPISE) As a Prognostic Marker for Emerging Dysglycemia in Children with Overweight or Obesity |
| title_full | Single Point Insulin Sensitivity Estimator (SPISE) As a Prognostic Marker for Emerging Dysglycemia in Children with Overweight or Obesity |
| title_fullStr | Single Point Insulin Sensitivity Estimator (SPISE) As a Prognostic Marker for Emerging Dysglycemia in Children with Overweight or Obesity |
| title_full_unstemmed | Single Point Insulin Sensitivity Estimator (SPISE) As a Prognostic Marker for Emerging Dysglycemia in Children with Overweight or Obesity |
| title_short | Single Point Insulin Sensitivity Estimator (SPISE) As a Prognostic Marker for Emerging Dysglycemia in Children with Overweight or Obesity |
| title_sort | single point insulin sensitivity estimator spise as a prognostic marker for emerging dysglycemia in children with overweight or obesity |
| topic | SPISE childhood obesity dysglycemia early-onset diabetes prediabetes type 2 diabetes |
| url | https://www.mdpi.com/2218-1989/13/1/100 |
| work_keys_str_mv | AT robertstein singlepointinsulinsensitivityestimatorspiseasaprognosticmarkerforemergingdysglycemiainchildrenwithoverweightorobesity AT floriankoutny singlepointinsulinsensitivityestimatorspiseasaprognosticmarkerforemergingdysglycemiainchildrenwithoverweightorobesity AT johannesriedel singlepointinsulinsensitivityestimatorspiseasaprognosticmarkerforemergingdysglycemiainchildrenwithoverweightorobesity AT nataschadorr singlepointinsulinsensitivityestimatorspiseasaprognosticmarkerforemergingdysglycemiainchildrenwithoverweightorobesity AT klarameyer singlepointinsulinsensitivityestimatorspiseasaprognosticmarkerforemergingdysglycemiainchildrenwithoverweightorobesity AT marcocolombo singlepointinsulinsensitivityestimatorspiseasaprognosticmarkerforemergingdysglycemiainchildrenwithoverweightorobesity AT mandyvogel singlepointinsulinsensitivityestimatorspiseasaprognosticmarkerforemergingdysglycemiainchildrenwithoverweightorobesity AT christianheinzanderwald singlepointinsulinsensitivityestimatorspiseasaprognosticmarkerforemergingdysglycemiainchildrenwithoverweightorobesity AT matthiasbluher singlepointinsulinsensitivityestimatorspiseasaprognosticmarkerforemergingdysglycemiainchildrenwithoverweightorobesity AT wielandkiess singlepointinsulinsensitivityestimatorspiseasaprognosticmarkerforemergingdysglycemiainchildrenwithoverweightorobesity AT antjekorner singlepointinsulinsensitivityestimatorspiseasaprognosticmarkerforemergingdysglycemiainchildrenwithoverweightorobesity AT danielweghuber singlepointinsulinsensitivityestimatorspiseasaprognosticmarkerforemergingdysglycemiainchildrenwithoverweightorobesity |