Epidemiology of hepatocellular carcinoma in sub-Saharan Africa
Published incidences of hepatocellular carcinoma in the Black population of sub-Saharan Africa underestimate the true incidence of the tumor because of the many instances in which hepatocellular carcinoma is either not definitively diagnosed or is not recorded in a cancer registry. Despite this, it...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-03-01
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| Series: | Annals of Hepatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119313547 |
| _version_ | 1818608165508349952 |
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| author | Michael C. Kew |
| author_facet | Michael C. Kew |
| author_sort | Michael C. Kew |
| collection | DOAJ |
| description | Published incidences of hepatocellular carcinoma in the Black population of sub-Saharan Africa underestimate the true incidence of the tumor because of the many instances in which hepatocellular carcinoma is either not definitively diagnosed or is not recorded in a cancer registry. Despite this, it is manifestly evident that the tumor occurs commonly and is a major cause of cancer deaths in Black African peoples living in the sub-continent, particularly in those living in rural areas. 46,000 new cases of hepatocellular carcinoma have been recorded to be diagnosed in sub-Saharan Africa each year, and age-standardized incidences of the tumor as high as 41.2/100,000 persons/year have been documented. The highest incidence of hepatocellular carcinoma has been recorded in Mozambique. The tumor occurs at a young age in rural dwelling and, to a lesser extent, urban dwelling Black Africans. It is also more common in men than women, particularly in the younger patients. Cirrhosis co-exists with hepatocellular carcinoma in about 60% of patients and is equally common in the two sexes. The tumor is not only common in the Black African population, it also carries an especially grave prognosis, with about 93% of the patients dying within 12 months of the onset of symptoms. Caucasians living in the sub-continent have a low incidence of hepatocellular carcinoma and it occurs at an older age. |
| first_indexed | 2024-12-16T14:38:19Z |
| format | Article |
| id | doaj.art-5c740b4165f044e5a94b40494bbd6dff |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-16T14:38:19Z |
| publishDate | 2013-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-5c740b4165f044e5a94b40494bbd6dff2022-12-21T22:28:02ZengElsevierAnnals of Hepatology1665-26812013-03-01122173182Epidemiology of hepatocellular carcinoma in sub-Saharan AfricaMichael C. Kew0Correspondence and reprint request:; Department of Medicine, Groote Schuur Hospital, and University of Cape Town, Cape Town, and Department of Medicine, University of the Witatersrand, Johannesburg, South AfricaPublished incidences of hepatocellular carcinoma in the Black population of sub-Saharan Africa underestimate the true incidence of the tumor because of the many instances in which hepatocellular carcinoma is either not definitively diagnosed or is not recorded in a cancer registry. Despite this, it is manifestly evident that the tumor occurs commonly and is a major cause of cancer deaths in Black African peoples living in the sub-continent, particularly in those living in rural areas. 46,000 new cases of hepatocellular carcinoma have been recorded to be diagnosed in sub-Saharan Africa each year, and age-standardized incidences of the tumor as high as 41.2/100,000 persons/year have been documented. The highest incidence of hepatocellular carcinoma has been recorded in Mozambique. The tumor occurs at a young age in rural dwelling and, to a lesser extent, urban dwelling Black Africans. It is also more common in men than women, particularly in the younger patients. Cirrhosis co-exists with hepatocellular carcinoma in about 60% of patients and is equally common in the two sexes. The tumor is not only common in the Black African population, it also carries an especially grave prognosis, with about 93% of the patients dying within 12 months of the onset of symptoms. Caucasians living in the sub-continent have a low incidence of hepatocellular carcinoma and it occurs at an older age.http://www.sciencedirect.com/science/article/pii/S1665268119313547EpidemiologyHepatocellular carcinomaSub-Saharan Africa |
| spellingShingle | Michael C. Kew Epidemiology of hepatocellular carcinoma in sub-Saharan Africa Annals of Hepatology Epidemiology Hepatocellular carcinoma Sub-Saharan Africa |
| title | Epidemiology of hepatocellular carcinoma in sub-Saharan Africa |
| title_full | Epidemiology of hepatocellular carcinoma in sub-Saharan Africa |
| title_fullStr | Epidemiology of hepatocellular carcinoma in sub-Saharan Africa |
| title_full_unstemmed | Epidemiology of hepatocellular carcinoma in sub-Saharan Africa |
| title_short | Epidemiology of hepatocellular carcinoma in sub-Saharan Africa |
| title_sort | epidemiology of hepatocellular carcinoma in sub saharan africa |
| topic | Epidemiology Hepatocellular carcinoma Sub-Saharan Africa |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119313547 |
| work_keys_str_mv | AT michaelckew epidemiologyofhepatocellularcarcinomainsubsaharanafrica |