Neurophysiological Parameters Influencing Sleep–Wake Discrepancy in Insomnia Disorder: A Preliminary Analysis on Alpha Rhythm during Sleep Onset
Sleep state misperception (SSM) is a common issue in insomnia disorder (ID), causing a discrepancy between objective and subjective sleep/wake time estimation and increased daytime impairments. In this context, the hyperarousal theory assumes that sustained central nervous system activation contribu...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/14/1/97 |
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| author | Francesca Berra Elisabetta Fasiello Marco Zucconi Francesca Casoni Luigi De Gennaro Luigi Ferini-Strambi Andrea Galbiati |
| author_facet | Francesca Berra Elisabetta Fasiello Marco Zucconi Francesca Casoni Luigi De Gennaro Luigi Ferini-Strambi Andrea Galbiati |
| author_sort | Francesca Berra |
| collection | DOAJ |
| description | Sleep state misperception (SSM) is a common issue in insomnia disorder (ID), causing a discrepancy between objective and subjective sleep/wake time estimation and increased daytime impairments. In this context, the hyperarousal theory assumes that sustained central nervous system activation contributes to the SSM. This study investigates factors influencing SSM during sleep latency (SL) and total sleep time (TST). Objective polysomnographic sleep variables (the alpha density index, latency-to-sleep stages and the first K-complex, and Rapid Eye Movement (REM) arousal density) and subjective sleep indices, taken from sleep diaries, were analyzed in 16 ID patients. Correlation analyses revealed a positive association between the degree of SL misperception (SLm) and the percentage of epochs that contained a visually scored stereotyped alpha rhythm during objective SL. A regression analysis showed that the REM arousal density and alpha density index significantly predicted TST misperception (TSTm). Furthermore, the degree of SLm was associated with an increased probability of transitioning from stage 1 of non-REM sleep to wakefulness during subjective SL. These findings support the role of hyperarousal in SSM and highlight the importance of alpha activity in unravelling the heterogeneous underpinnings of SSM. |
| first_indexed | 2024-03-08T11:03:15Z |
| format | Article |
| id | doaj.art-5c74ab9a2ef44f7497fa90832d536134 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-08T11:03:15Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-5c74ab9a2ef44f7497fa90832d5361342024-01-26T15:25:24ZengMDPI AGBrain Sciences2076-34252024-01-011419710.3390/brainsci14010097Neurophysiological Parameters Influencing Sleep–Wake Discrepancy in Insomnia Disorder: A Preliminary Analysis on Alpha Rhythm during Sleep OnsetFrancesca Berra0Elisabetta Fasiello1Marco Zucconi2Francesca Casoni3Luigi De Gennaro4Luigi Ferini-Strambi5Andrea Galbiati6Department of Psychology, “Vita-Salute” San Raffaele University, 20132 Milan, ItalyDepartment of Psychology, “Vita-Salute” San Raffaele University, 20132 Milan, ItalyIRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences, Neurology–Sleep Disorders Center, 20132 Milan, ItalyIRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences, Neurology–Sleep Disorders Center, 20132 Milan, ItalyDepartment of Psychology, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Psychology, “Vita-Salute” San Raffaele University, 20132 Milan, ItalyDepartment of Psychology, “Vita-Salute” San Raffaele University, 20132 Milan, ItalySleep state misperception (SSM) is a common issue in insomnia disorder (ID), causing a discrepancy between objective and subjective sleep/wake time estimation and increased daytime impairments. In this context, the hyperarousal theory assumes that sustained central nervous system activation contributes to the SSM. This study investigates factors influencing SSM during sleep latency (SL) and total sleep time (TST). Objective polysomnographic sleep variables (the alpha density index, latency-to-sleep stages and the first K-complex, and Rapid Eye Movement (REM) arousal density) and subjective sleep indices, taken from sleep diaries, were analyzed in 16 ID patients. Correlation analyses revealed a positive association between the degree of SL misperception (SLm) and the percentage of epochs that contained a visually scored stereotyped alpha rhythm during objective SL. A regression analysis showed that the REM arousal density and alpha density index significantly predicted TST misperception (TSTm). Furthermore, the degree of SLm was associated with an increased probability of transitioning from stage 1 of non-REM sleep to wakefulness during subjective SL. These findings support the role of hyperarousal in SSM and highlight the importance of alpha activity in unravelling the heterogeneous underpinnings of SSM.https://www.mdpi.com/2076-3425/14/1/97insomnia disordersleep disordersleep state misperceptionsleep discrepancypolysomnographyhyperarousal theory |
| spellingShingle | Francesca Berra Elisabetta Fasiello Marco Zucconi Francesca Casoni Luigi De Gennaro Luigi Ferini-Strambi Andrea Galbiati Neurophysiological Parameters Influencing Sleep–Wake Discrepancy in Insomnia Disorder: A Preliminary Analysis on Alpha Rhythm during Sleep Onset Brain Sciences insomnia disorder sleep disorder sleep state misperception sleep discrepancy polysomnography hyperarousal theory |
| title | Neurophysiological Parameters Influencing Sleep–Wake Discrepancy in Insomnia Disorder: A Preliminary Analysis on Alpha Rhythm during Sleep Onset |
| title_full | Neurophysiological Parameters Influencing Sleep–Wake Discrepancy in Insomnia Disorder: A Preliminary Analysis on Alpha Rhythm during Sleep Onset |
| title_fullStr | Neurophysiological Parameters Influencing Sleep–Wake Discrepancy in Insomnia Disorder: A Preliminary Analysis on Alpha Rhythm during Sleep Onset |
| title_full_unstemmed | Neurophysiological Parameters Influencing Sleep–Wake Discrepancy in Insomnia Disorder: A Preliminary Analysis on Alpha Rhythm during Sleep Onset |
| title_short | Neurophysiological Parameters Influencing Sleep–Wake Discrepancy in Insomnia Disorder: A Preliminary Analysis on Alpha Rhythm during Sleep Onset |
| title_sort | neurophysiological parameters influencing sleep wake discrepancy in insomnia disorder a preliminary analysis on alpha rhythm during sleep onset |
| topic | insomnia disorder sleep disorder sleep state misperception sleep discrepancy polysomnography hyperarousal theory |
| url | https://www.mdpi.com/2076-3425/14/1/97 |
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