The Impacts of Teriparatide Treatment on Bone Alkaline Phosphatase, Calcium and Phosphate Serum Levels in Rats
Trauma, tooth loss, cancer surgery, congenital malformations, periodontal disease, and oral-maxillofacial surgery are all major causes of bone loss, deformity, or fracture. Bone healing is a physiologically complicated process that also incorporates mechanical factors. Too many doubts concerning bon...
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| Format: | Article |
| Language: | English |
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Egyptian Society for Animal Management
2024-01-01
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| Series: | Journal of Applied Veterinary Sciences |
| Subjects: | |
| Online Access: | https://javs.journals.ekb.eg/article_327565_2124acd51c3b320174b9791930326d77.pdf |
| _version_ | 1797374907526414336 |
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| author | Duaa Ahmed Wael Al-Wattar Ghada A. Taqa |
| author_facet | Duaa Ahmed Wael Al-Wattar Ghada A. Taqa |
| author_sort | Duaa Ahmed |
| collection | DOAJ |
| description | Trauma, tooth loss, cancer surgery, congenital malformations, periodontal disease, and oral-maxillofacial surgery are all major causes of bone loss, deformity, or fracture. Bone healing is a physiologically complicated process that also incorporates mechanical factors. Too many doubts concerning bone regeneration and the conditions that promote it have persisted for far too long. To assess the impact of systemic teriparatide therapy on mandibular bone defects healing.Forty male albino rats were randomly divided into two groups: the control group and the treatment group, with 20 rats per group. All rats had the same surgical technique. A small hole was created in the mandible, measuring 3 mm in diameter and 3 mm in depth, and then left unoccupied. The treatment group received a daily subcutaneous injection of Teriparatide at a dose of 10 µg/kg. Animals were subjected to euthanasia at four distinct time intervals (7, 14, 21, and 28) days. Biochemical analyses were done. Teriparatide was shown to elevate serum levels of bone alkaline phosphatase (BALP), elevate serum calcium concentration levels, and lower serum phosphate. There were statistically significant differences in the levels of BALP between the control group and the treated group at 7, 14, and 21 days after the surgical procedure and there was a statistically significant difference in serum calcium levels between the treated group and the control group on day 14 of the experiment. The findings of this research suggest that the systemic administration of teriparatide resulted in an acceleration of bone healing. This was evidenced by a notable elevation in bone alkaline phosphatase levels as seen in the biochemical analysis. Teriparatide slightly elevated serum calcium levels and lowered serum phosphate levels because it is a synthetic parathyroid hormone. |
| first_indexed | 2024-03-08T19:12:33Z |
| format | Article |
| id | doaj.art-5c74df3e88f2469ab6be1d3df8332db1 |
| institution | Directory Open Access Journal |
| issn | 1687-4072 2090-3308 |
| language | English |
| last_indexed | 2024-03-08T19:12:33Z |
| publishDate | 2024-01-01 |
| publisher | Egyptian Society for Animal Management |
| record_format | Article |
| series | Journal of Applied Veterinary Sciences |
| spelling | doaj.art-5c74df3e88f2469ab6be1d3df8332db12023-12-27T10:01:49ZengEgyptian Society for Animal ManagementJournal of Applied Veterinary Sciences1687-40722090-33082024-01-0191556010.21608/javs.2023.240748.1281327565The Impacts of Teriparatide Treatment on Bone Alkaline Phosphatase, Calcium and Phosphate Serum Levels in RatsDuaa Ahmed0Wael Al-Wattar1Ghada A. Taqa2Ministry of Health, Nineveh Health Directorate, Mosul, IraqDepartment of Oral and Maxillofacial Surgery, College of Dentistry, University of Mosul , Mosul, IraqProfessor in veterinary pharmacology and toxicology, College of Dentistry , Mosul university , IraqTrauma, tooth loss, cancer surgery, congenital malformations, periodontal disease, and oral-maxillofacial surgery are all major causes of bone loss, deformity, or fracture. Bone healing is a physiologically complicated process that also incorporates mechanical factors. Too many doubts concerning bone regeneration and the conditions that promote it have persisted for far too long. To assess the impact of systemic teriparatide therapy on mandibular bone defects healing.Forty male albino rats were randomly divided into two groups: the control group and the treatment group, with 20 rats per group. All rats had the same surgical technique. A small hole was created in the mandible, measuring 3 mm in diameter and 3 mm in depth, and then left unoccupied. The treatment group received a daily subcutaneous injection of Teriparatide at a dose of 10 µg/kg. Animals were subjected to euthanasia at four distinct time intervals (7, 14, 21, and 28) days. Biochemical analyses were done. Teriparatide was shown to elevate serum levels of bone alkaline phosphatase (BALP), elevate serum calcium concentration levels, and lower serum phosphate. There were statistically significant differences in the levels of BALP between the control group and the treated group at 7, 14, and 21 days after the surgical procedure and there was a statistically significant difference in serum calcium levels between the treated group and the control group on day 14 of the experiment. The findings of this research suggest that the systemic administration of teriparatide resulted in an acceleration of bone healing. This was evidenced by a notable elevation in bone alkaline phosphatase levels as seen in the biochemical analysis. Teriparatide slightly elevated serum calcium levels and lowered serum phosphate levels because it is a synthetic parathyroid hormone.https://javs.journals.ekb.eg/article_327565_2124acd51c3b320174b9791930326d77.pdfbone alkaline phosphatasebone healingratteriparatide |
| spellingShingle | Duaa Ahmed Wael Al-Wattar Ghada A. Taqa The Impacts of Teriparatide Treatment on Bone Alkaline Phosphatase, Calcium and Phosphate Serum Levels in Rats Journal of Applied Veterinary Sciences bone alkaline phosphatase bone healing rat teriparatide |
| title | The Impacts of Teriparatide Treatment on Bone Alkaline Phosphatase, Calcium and Phosphate Serum Levels in Rats |
| title_full | The Impacts of Teriparatide Treatment on Bone Alkaline Phosphatase, Calcium and Phosphate Serum Levels in Rats |
| title_fullStr | The Impacts of Teriparatide Treatment on Bone Alkaline Phosphatase, Calcium and Phosphate Serum Levels in Rats |
| title_full_unstemmed | The Impacts of Teriparatide Treatment on Bone Alkaline Phosphatase, Calcium and Phosphate Serum Levels in Rats |
| title_short | The Impacts of Teriparatide Treatment on Bone Alkaline Phosphatase, Calcium and Phosphate Serum Levels in Rats |
| title_sort | impacts of teriparatide treatment on bone alkaline phosphatase calcium and phosphate serum levels in rats |
| topic | bone alkaline phosphatase bone healing rat teriparatide |
| url | https://javs.journals.ekb.eg/article_327565_2124acd51c3b320174b9791930326d77.pdf |
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