Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppression of endoplasmic reticulum stress

Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppression of endoplasmic reticulum stress

Background: Compound K (CK) is among the protopanaxadiol (PPD)-type ginsenoside group, which produces multiple pharmacological effects. Herein, we examined the effects of CK on muscle atrophy under hyperlipidemic conditions along with its pro-myogenic effects. Further, the molecular pathways underly...

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Bibliographic Details
Main Authors: Tae Jin Kim, Do Hyeon Pyun, Myeong Jun Kim, Ji Hoon Jeong, A.M. Abd El-Aty, Tae Woo Jung
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Journal of Ginseng Research
Subjects:
Compound K
AMPK
Autophagy
ER stress
Myogenesis
Sarcopenia
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845321001342

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