Research progress on the role of PDGF/PDGFR in type 2 diabetes
Platelet-derived growth factors (PDGFs) are basic proteins stored in the α granules of platelets. PDGFs and their receptors (PDGFRs) are widely expressed in platelets, fibroblasts, vascular endothelial cells, platelets, pericytes, smooth muscle cells and tumor cells. The activation of PDGFR plays a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223007734 |
| _version_ | 1797801841430364160 |
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| author | Zhanqi Cao Yijie Liu Yini Wang Ping Leng |
| author_facet | Zhanqi Cao Yijie Liu Yini Wang Ping Leng |
| author_sort | Zhanqi Cao |
| collection | DOAJ |
| description | Platelet-derived growth factors (PDGFs) are basic proteins stored in the α granules of platelets. PDGFs and their receptors (PDGFRs) are widely expressed in platelets, fibroblasts, vascular endothelial cells, platelets, pericytes, smooth muscle cells and tumor cells. The activation of PDGFR plays a number of critical roles in physiological functions and diseases, including normal embryonic development, cellular differentiation, and responses to tissue damage. In recent years, emerging experimental evidence has shown that activation of the PDGF/PDGFR pathway is involved in the development of diabetes and its complications, such as atherosclerosis, diabetic foot ulcers, diabetic nephropathy, and retinopathy. Research on targeting PDGF/PDGFR as a treatment has also made great progress. In this mini-review, we summarized the role of PDGF in diabetes, as well as the research progress on targeted diabetes therapy, which provides a new strategy for the treatment of type 2 diabetes. |
| first_indexed | 2024-03-13T04:56:40Z |
| format | Article |
| id | doaj.art-5c771d3c73b8408d82866c7ad39bc054 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T04:56:40Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-5c771d3c73b8408d82866c7ad39bc0542023-06-18T05:00:56ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-08-01164114983Research progress on the role of PDGF/PDGFR in type 2 diabetesZhanqi Cao0Yijie Liu1Yini Wang2Ping Leng3Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao 266003, ChinaDepartment of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao 266003, ChinaDepartment of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao 266003, ChinaCorrespondence to: Department of Pharmacy, The Affiliated Hospital of Qingdao University, No. 16 Jiang Su Road, Qingdao 266003, China.; Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao 266003, ChinaPlatelet-derived growth factors (PDGFs) are basic proteins stored in the α granules of platelets. PDGFs and their receptors (PDGFRs) are widely expressed in platelets, fibroblasts, vascular endothelial cells, platelets, pericytes, smooth muscle cells and tumor cells. The activation of PDGFR plays a number of critical roles in physiological functions and diseases, including normal embryonic development, cellular differentiation, and responses to tissue damage. In recent years, emerging experimental evidence has shown that activation of the PDGF/PDGFR pathway is involved in the development of diabetes and its complications, such as atherosclerosis, diabetic foot ulcers, diabetic nephropathy, and retinopathy. Research on targeting PDGF/PDGFR as a treatment has also made great progress. In this mini-review, we summarized the role of PDGF in diabetes, as well as the research progress on targeted diabetes therapy, which provides a new strategy for the treatment of type 2 diabetes.http://www.sciencedirect.com/science/article/pii/S0753332223007734PDGFPDGFRDiabetes complicationsAtheroscleroticRetinopathy |
| spellingShingle | Zhanqi Cao Yijie Liu Yini Wang Ping Leng Research progress on the role of PDGF/PDGFR in type 2 diabetes Biomedicine & Pharmacotherapy PDGF PDGFR Diabetes complications Atherosclerotic Retinopathy |
| title | Research progress on the role of PDGF/PDGFR in type 2 diabetes |
| title_full | Research progress on the role of PDGF/PDGFR in type 2 diabetes |
| title_fullStr | Research progress on the role of PDGF/PDGFR in type 2 diabetes |
| title_full_unstemmed | Research progress on the role of PDGF/PDGFR in type 2 diabetes |
| title_short | Research progress on the role of PDGF/PDGFR in type 2 diabetes |
| title_sort | research progress on the role of pdgf pdgfr in type 2 diabetes |
| topic | PDGF PDGFR Diabetes complications Atherosclerotic Retinopathy |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223007734 |
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