Digital light processing of β-tricalcium phosphate bioceramic scaffolds with controllable porous structures for patient specific craniomaxillofacial bone reconstruction
β-TCP scaffolds with four representative pore configurations are prepared for using digital light processing (DLP)-based additive manufacturing. The process optimization, pore design, mechanical properties, and microstructure of the fabricated scaffolds are investigated. The optimal slurry solid con...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522001794 |
| _version_ | 1818278648975720448 |
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| author | Faqiang Zhang Jingzhou Yang Yangbo Zuo Kaixin Li Zhe Mao Xia Jin Shupei Zhang Hairui Gao Yingqiu Cui |
| author_facet | Faqiang Zhang Jingzhou Yang Yangbo Zuo Kaixin Li Zhe Mao Xia Jin Shupei Zhang Hairui Gao Yingqiu Cui |
| author_sort | Faqiang Zhang |
| collection | DOAJ |
| description | β-TCP scaffolds with four representative pore configurations are prepared for using digital light processing (DLP)-based additive manufacturing. The process optimization, pore design, mechanical properties, and microstructure of the fabricated scaffolds are investigated. The optimal slurry solid content, exposure intensity, slice thickness, and exposure time were found to be 60 wt%, 10 mW/cm2, 25 μm, and 4 s, respectively. The DLP-formed β-TCP bone scaffolds showed 3D interconnected and multilevel pores, achieving porosities of 49%–89% and strut diameters of 200–1000 μm. The primary pore size exceeded 100 μm, and the secondary pore size was less than 10 μm. The porosity significantly affected the mechanical properties of the scaffolds, whereas the pore configuration exerted a minor influence. The prepared scaffolds with a pore configuration of triply periodic minimal surface behaved the best mechanical properties. The compressive strength and elastic modulus of the scaffolds reached 20–30 MPa and 2–4 GPa, respectively. Based on patient’s medical imaging data, large-volume β-TCP scaffolds (∽70 × 40 × 15 mm and 40 × 40 × 4 mm, after sintering) with controlled biomimicking porous structures and anatomical shapes were successfully designed and fabricated by DLP for repair of massively damaged mandible and cranial defects. |
| first_indexed | 2024-12-12T23:20:47Z |
| format | Article |
| id | doaj.art-5c77fa1e965a4416b5f8a4c593352050 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-12-12T23:20:47Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-5c77fa1e965a4416b5f8a4c5933520502022-12-22T00:08:17ZengElsevierMaterials & Design0264-12752022-04-01216110558Digital light processing of β-tricalcium phosphate bioceramic scaffolds with controllable porous structures for patient specific craniomaxillofacial bone reconstructionFaqiang Zhang0Jingzhou Yang1Yangbo Zuo2Kaixin Li3Zhe Mao4Xia Jin5Shupei Zhang6Hairui Gao7Yingqiu Cui8Department of Oral and Maxillofacial Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou, Guangdong, PR China; School of Mechanical & Automobile Engineering, Qingdao University of Technology, Qingdao, Shandong, PR ChinaDepartment of Oral and Maxillofacial Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou, Guangdong, PR China; School of Mechanical & Automobile Engineering, Qingdao University of Technology, Qingdao, Shandong, PR China; Shenzhen Dazhou Medical Technology Co, Ltd., Shenzhen, Guangdong, PR China; Center of Biomedical Materials 3D Printing, National Engineering Laboratory for Polymer Complex Structure Additive Manufacturing, Baoding, Hebei, PR China; Corresponding authors at: 6th Floor, Building 5, 318 Renmin Middle Road, Yuexiu District, Guangzhou, Guangdong 510000, PR China.Shenzhen Dazhou Medical Technology Co, Ltd., Shenzhen, Guangdong, PR China; Center of Biomedical Materials 3D Printing, National Engineering Laboratory for Polymer Complex Structure Additive Manufacturing, Baoding, Hebei, PR ChinaSchool of Civil Engineering, Hebei University of Engineering, Handan, Hebei, PR ChinaDepartment of Oral and Maxillofacial Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou, Guangdong, PR ChinaSchool of Mechanical & Automobile Engineering, Qingdao University of Technology, Qingdao, Shandong, PR China; Corresponding authors at: 6th Floor, Building 5, 318 Renmin Middle Road, Yuexiu District, Guangzhou, Guangdong 510000, PR China.Shenzhen Dazhou Medical Technology Co, Ltd., Shenzhen, Guangdong, PR China; Center of Biomedical Materials 3D Printing, National Engineering Laboratory for Polymer Complex Structure Additive Manufacturing, Baoding, Hebei, PR ChinaSchool of Mechanical & Automobile Engineering, Qingdao University of Technology, Qingdao, Shandong, PR ChinaDepartment of Oral and Maxillofacial Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou, Guangdong, PR China; Corresponding authors at: 6th Floor, Building 5, 318 Renmin Middle Road, Yuexiu District, Guangzhou, Guangdong 510000, PR China.β-TCP scaffolds with four representative pore configurations are prepared for using digital light processing (DLP)-based additive manufacturing. The process optimization, pore design, mechanical properties, and microstructure of the fabricated scaffolds are investigated. The optimal slurry solid content, exposure intensity, slice thickness, and exposure time were found to be 60 wt%, 10 mW/cm2, 25 μm, and 4 s, respectively. The DLP-formed β-TCP bone scaffolds showed 3D interconnected and multilevel pores, achieving porosities of 49%–89% and strut diameters of 200–1000 μm. The primary pore size exceeded 100 μm, and the secondary pore size was less than 10 μm. The porosity significantly affected the mechanical properties of the scaffolds, whereas the pore configuration exerted a minor influence. The prepared scaffolds with a pore configuration of triply periodic minimal surface behaved the best mechanical properties. The compressive strength and elastic modulus of the scaffolds reached 20–30 MPa and 2–4 GPa, respectively. Based on patient’s medical imaging data, large-volume β-TCP scaffolds (∽70 × 40 × 15 mm and 40 × 40 × 4 mm, after sintering) with controlled biomimicking porous structures and anatomical shapes were successfully designed and fabricated by DLP for repair of massively damaged mandible and cranial defects.http://www.sciencedirect.com/science/article/pii/S0264127522001794Additive manufacturing3D printingTCP bioceramicBone scaffoldCranio-maxillofacial bone reconstruction |
| spellingShingle | Faqiang Zhang Jingzhou Yang Yangbo Zuo Kaixin Li Zhe Mao Xia Jin Shupei Zhang Hairui Gao Yingqiu Cui Digital light processing of β-tricalcium phosphate bioceramic scaffolds with controllable porous structures for patient specific craniomaxillofacial bone reconstruction Materials & Design Additive manufacturing 3D printing TCP bioceramic Bone scaffold Cranio-maxillofacial bone reconstruction |
| title | Digital light processing of β-tricalcium phosphate bioceramic scaffolds with controllable porous structures for patient specific craniomaxillofacial bone reconstruction |
| title_full | Digital light processing of β-tricalcium phosphate bioceramic scaffolds with controllable porous structures for patient specific craniomaxillofacial bone reconstruction |
| title_fullStr | Digital light processing of β-tricalcium phosphate bioceramic scaffolds with controllable porous structures for patient specific craniomaxillofacial bone reconstruction |
| title_full_unstemmed | Digital light processing of β-tricalcium phosphate bioceramic scaffolds with controllable porous structures for patient specific craniomaxillofacial bone reconstruction |
| title_short | Digital light processing of β-tricalcium phosphate bioceramic scaffolds with controllable porous structures for patient specific craniomaxillofacial bone reconstruction |
| title_sort | digital light processing of β tricalcium phosphate bioceramic scaffolds with controllable porous structures for patient specific craniomaxillofacial bone reconstruction |
| topic | Additive manufacturing 3D printing TCP bioceramic Bone scaffold Cranio-maxillofacial bone reconstruction |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522001794 |
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