Antiulcer Activity of Anthraquinone–Flavonoid Complex of <i>Rumex tianschanicus</i> Losinsk
The composition of an ethanol extract from the roots of <i>Rumex tianschanicus</i> Losinsk of the Trans-Ili Alatau wild flora was studied in order to determine its antiulcer activity. The phytochemical composition of the anthraquinone–flavonoid complex from (AFC) <i>R. tianschanicu...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/5/2347 |
| _version_ | 1797614733908508672 |
|---|---|
| author | Gulnaz A. Seitimova Aksholpan K. Shokan Tatyana G. Tolstikova Nataliya A. Zhukova Dmitriy Yu. Korulkin Nataliya O. Kudrina Yuliya A. Litvinenko Nataliya D. Meduntseva Nina V. Terletskaya Timur E. Kulmanov |
| author_facet | Gulnaz A. Seitimova Aksholpan K. Shokan Tatyana G. Tolstikova Nataliya A. Zhukova Dmitriy Yu. Korulkin Nataliya O. Kudrina Yuliya A. Litvinenko Nataliya D. Meduntseva Nina V. Terletskaya Timur E. Kulmanov |
| author_sort | Gulnaz A. Seitimova |
| collection | DOAJ |
| description | The composition of an ethanol extract from the roots of <i>Rumex tianschanicus</i> Losinsk of the Trans-Ili Alatau wild flora was studied in order to determine its antiulcer activity. The phytochemical composition of the anthraquinone–flavonoid complex from (AFC) <i>R. tianschanicus</i> revealed the presence of numerous polyphenolic compounds, the most abundant of which are anthraquinones (1.77%), flavonoids (6.95%), and tannins (13.39%). The use of column chromatography (CC) and thin-layer chromatography (TLC) in conjunction with UV, IR, NMR spectroscopy, and mass spectrometry data allowed the researchers to isolate and identify the major components of the anthraquinone–flavonoid complex’s polyphenol fraction: physcion, chrysophanol, emodin, isorhamnetin, quercetin, and myricetin. The gastroprotective effect of the polyphenolic fraction of the anthraquinone–flavonoid complex (AFC) of <i>R. tianschanicus</i> roots was examined in an experimental model of rat gastric ulcer induced by indomethacin. The preventive and therapeutic effect of the anthraquinone–flavonoid complex at a dose of 100 mg/kg was analyzed using intragastric administration per day for 1 to 10 days, followed by a histological examination of stomach tissues. It has been demonstrated that prophylactic and prolonged use of the AFC <i>R. tianschanicus</i> in laboratory animals resulted in significantly less pronounced hemodynamic and desquamative changes in the epithelium of gastric tissues. The acquired results thus offer fresh insight into the anthraquinone and flavonoid metabolite component composition of <i>R. tianschanicus</i> roots, and they imply that the examined extract can be used to develop herbal medicines with antiulcer activity. |
| first_indexed | 2024-03-11T07:16:30Z |
| format | Article |
| id | doaj.art-5c7906258fa64a8a9994a16109b7dddf |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T07:16:30Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5c7906258fa64a8a9994a16109b7dddf2023-11-17T08:15:27ZengMDPI AGMolecules1420-30492023-03-01285234710.3390/molecules28052347Antiulcer Activity of Anthraquinone–Flavonoid Complex of <i>Rumex tianschanicus</i> LosinskGulnaz A. Seitimova0Aksholpan K. Shokan1Tatyana G. Tolstikova2Nataliya A. Zhukova3Dmitriy Yu. Korulkin4Nataliya O. Kudrina5Yuliya A. Litvinenko6Nataliya D. Meduntseva7Nina V. Terletskaya8Timur E. Kulmanov9Faculty of Biology and Biotechnology and Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Av., 71, Almaty 050040, KazakhstanFaculty of Biology and Biotechnology and Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Av., 71, Almaty 050040, KazakhstanN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Science, 630090 Novosibirsk, RussiaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Science, 630090 Novosibirsk, RussiaFaculty of Biology and Biotechnology and Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Av., 71, Almaty 050040, KazakhstanFaculty of Biology and Biotechnology and Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Av., 71, Almaty 050040, KazakhstanFaculty of Biology and Biotechnology and Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Av., 71, Almaty 050040, KazakhstanFaculty of Biology and Biotechnology and Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Av., 71, Almaty 050040, KazakhstanFaculty of Biology and Biotechnology and Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Av., 71, Almaty 050040, KazakhstanInstitute of Genetic and Physiology, Al-Farabi Av., 93, Almaty 050040, KazakhstanThe composition of an ethanol extract from the roots of <i>Rumex tianschanicus</i> Losinsk of the Trans-Ili Alatau wild flora was studied in order to determine its antiulcer activity. The phytochemical composition of the anthraquinone–flavonoid complex from (AFC) <i>R. tianschanicus</i> revealed the presence of numerous polyphenolic compounds, the most abundant of which are anthraquinones (1.77%), flavonoids (6.95%), and tannins (13.39%). The use of column chromatography (CC) and thin-layer chromatography (TLC) in conjunction with UV, IR, NMR spectroscopy, and mass spectrometry data allowed the researchers to isolate and identify the major components of the anthraquinone–flavonoid complex’s polyphenol fraction: physcion, chrysophanol, emodin, isorhamnetin, quercetin, and myricetin. The gastroprotective effect of the polyphenolic fraction of the anthraquinone–flavonoid complex (AFC) of <i>R. tianschanicus</i> roots was examined in an experimental model of rat gastric ulcer induced by indomethacin. The preventive and therapeutic effect of the anthraquinone–flavonoid complex at a dose of 100 mg/kg was analyzed using intragastric administration per day for 1 to 10 days, followed by a histological examination of stomach tissues. It has been demonstrated that prophylactic and prolonged use of the AFC <i>R. tianschanicus</i> in laboratory animals resulted in significantly less pronounced hemodynamic and desquamative changes in the epithelium of gastric tissues. The acquired results thus offer fresh insight into the anthraquinone and flavonoid metabolite component composition of <i>R. tianschanicus</i> roots, and they imply that the examined extract can be used to develop herbal medicines with antiulcer activity.https://www.mdpi.com/1420-3049/28/5/2347<i>Rumex tianschanicus</i> Losinskanthraquinoneflavonoidstomach ulcerantiulcer effect |
| spellingShingle | Gulnaz A. Seitimova Aksholpan K. Shokan Tatyana G. Tolstikova Nataliya A. Zhukova Dmitriy Yu. Korulkin Nataliya O. Kudrina Yuliya A. Litvinenko Nataliya D. Meduntseva Nina V. Terletskaya Timur E. Kulmanov Antiulcer Activity of Anthraquinone–Flavonoid Complex of <i>Rumex tianschanicus</i> Losinsk Molecules <i>Rumex tianschanicus</i> Losinsk anthraquinone flavonoid stomach ulcer antiulcer effect |
| title | Antiulcer Activity of Anthraquinone–Flavonoid Complex of <i>Rumex tianschanicus</i> Losinsk |
| title_full | Antiulcer Activity of Anthraquinone–Flavonoid Complex of <i>Rumex tianschanicus</i> Losinsk |
| title_fullStr | Antiulcer Activity of Anthraquinone–Flavonoid Complex of <i>Rumex tianschanicus</i> Losinsk |
| title_full_unstemmed | Antiulcer Activity of Anthraquinone–Flavonoid Complex of <i>Rumex tianschanicus</i> Losinsk |
| title_short | Antiulcer Activity of Anthraquinone–Flavonoid Complex of <i>Rumex tianschanicus</i> Losinsk |
| title_sort | antiulcer activity of anthraquinone flavonoid complex of i rumex tianschanicus i losinsk |
| topic | <i>Rumex tianschanicus</i> Losinsk anthraquinone flavonoid stomach ulcer antiulcer effect |
| url | https://www.mdpi.com/1420-3049/28/5/2347 |
| work_keys_str_mv | AT gulnazaseitimova antiulceractivityofanthraquinoneflavonoidcomplexofirumextianschanicusilosinsk AT aksholpankshokan antiulceractivityofanthraquinoneflavonoidcomplexofirumextianschanicusilosinsk AT tatyanagtolstikova antiulceractivityofanthraquinoneflavonoidcomplexofirumextianschanicusilosinsk AT nataliyaazhukova antiulceractivityofanthraquinoneflavonoidcomplexofirumextianschanicusilosinsk AT dmitriyyukorulkin antiulceractivityofanthraquinoneflavonoidcomplexofirumextianschanicusilosinsk AT nataliyaokudrina antiulceractivityofanthraquinoneflavonoidcomplexofirumextianschanicusilosinsk AT yuliyaalitvinenko antiulceractivityofanthraquinoneflavonoidcomplexofirumextianschanicusilosinsk AT nataliyadmeduntseva antiulceractivityofanthraquinoneflavonoidcomplexofirumextianschanicusilosinsk AT ninavterletskaya antiulceractivityofanthraquinoneflavonoidcomplexofirumextianschanicusilosinsk AT timurekulmanov antiulceractivityofanthraquinoneflavonoidcomplexofirumextianschanicusilosinsk |