Diacylglycerol kinases (DGKs): novel targets for improving T cell activity in cancer

Diacylglycerol kinases (DGKs): novel targets for improving T cell activity in cancer

Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the metabolism of diacylglycerol (DAG). Two isoforms of DGK, DGKα and DGKζ, specifically regulate the pool of DAG that is generated as a second messenger after stimulation of the T cell receptor (TCR). Deletion of either isoform in...

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Bibliographic Details
Main Authors: Matthew Riese, Edmund Moon, Bryon Johnson, Steven Albelda
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Diacylglycerol Kinase
Immunotherapy
T cell receptor
CD8+ T cell
diacylglycerol
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00108/full

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