Plasmablastic Lymphoma in a Previously Undiagnosed Human Immunodeficiency Virus-Positive Patient: A Case Report
Plasmablastic lymphoma (PBL) is a rare and aggressive non-Hodgkin lymphoma subtype associated with human immunodeficiency virus (HIV) infection. PBL is extremely aggressive and has a poor response to treatment. Clinically PBL resembles a periodontal disease, Kaposi sarcoma, or melanoma. Delayed diag...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Gazi University
2023-09-01
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| Series: | Acta Odontologica Turcica |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/2658260 |
| _version_ | 1827824791042654208 |
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| author | Mehmet Ali Altay Selmi Yılmaz Ayşe Taş Nelli Yıldırımyan |
| author_facet | Mehmet Ali Altay Selmi Yılmaz Ayşe Taş Nelli Yıldırımyan |
| author_sort | Mehmet Ali Altay |
| collection | DOAJ |
| description | Plasmablastic lymphoma (PBL) is a rare and aggressive non-Hodgkin lymphoma subtype associated with human immunodeficiency virus (HIV) infection. PBL is extremely aggressive and has a poor response to treatment. Clinically PBL resembles a periodontal disease, Kaposi sarcoma, or melanoma. Delayed diagnosis adversely affects the treatment and life expectancy. A 52-year-old male presented with a firm intraoral mass causing a slight elevation noticeable extraorally. Radiologically, loss of lamina dura around the first premolar and loss of both vertical and horizontal bone height around the dental implant replacing the second premolar were present. The biopsy confirmed a diagnosis of PBL. Further evaluation revealed that the patient was positive for HIV. The chemotherapy regimen included etoposide, vincristine, hydroxydaunorubicin, cyclophosphamide, and prednisolone, followed by an autologous hematopoietic stem cell bone marrow transplant. This article attempts to describe the clinical presentation and histopathological evaluation of PBL, and emphasize the paramount role of biopsy, early clinical suspicion, and correct diagnosis. |
| first_indexed | 2024-03-12T02:31:50Z |
| format | Article |
| id | doaj.art-5c7a80e423324598a7bd644c8938423d |
| institution | Directory Open Access Journal |
| issn | 2147-690X |
| language | English |
| last_indexed | 2024-03-12T02:31:50Z |
| publishDate | 2023-09-01 |
| publisher | Gazi University |
| record_format | Article |
| series | Acta Odontologica Turcica |
| spelling | doaj.art-5c7a80e423324598a7bd644c8938423d2023-09-05T07:42:59ZengGazi UniversityActa Odontologica Turcica2147-690X2023-09-01403929510.17214/gaziaot.117711429Plasmablastic Lymphoma in a Previously Undiagnosed Human Immunodeficiency Virus-Positive Patient: A Case ReportMehmet Ali Altay0Selmi Yılmaz1Ayşe Taş2Nelli Yıldırımyan3AKDENİZ ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİAKDENİZ ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİİSTANBUL MEDİPOL ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİISTANBUL MEDIPOL UNIVERSITY, FACULTY OF DENTISTRYPlasmablastic lymphoma (PBL) is a rare and aggressive non-Hodgkin lymphoma subtype associated with human immunodeficiency virus (HIV) infection. PBL is extremely aggressive and has a poor response to treatment. Clinically PBL resembles a periodontal disease, Kaposi sarcoma, or melanoma. Delayed diagnosis adversely affects the treatment and life expectancy. A 52-year-old male presented with a firm intraoral mass causing a slight elevation noticeable extraorally. Radiologically, loss of lamina dura around the first premolar and loss of both vertical and horizontal bone height around the dental implant replacing the second premolar were present. The biopsy confirmed a diagnosis of PBL. Further evaluation revealed that the patient was positive for HIV. The chemotherapy regimen included etoposide, vincristine, hydroxydaunorubicin, cyclophosphamide, and prednisolone, followed by an autologous hematopoietic stem cell bone marrow transplant. This article attempts to describe the clinical presentation and histopathological evaluation of PBL, and emphasize the paramount role of biopsy, early clinical suspicion, and correct diagnosis.https://dergipark.org.tr/tr/download/article-file/2658260plasmablastic lymphomahuman immunodeficiency virusgingival enlargementoral cavityplazmablastik lenfomainsan immünyetmezlik virüsüdiş eti büyümesiağız boşluğu |
| spellingShingle | Mehmet Ali Altay Selmi Yılmaz Ayşe Taş Nelli Yıldırımyan Plasmablastic Lymphoma in a Previously Undiagnosed Human Immunodeficiency Virus-Positive Patient: A Case Report Acta Odontologica Turcica plasmablastic lymphoma human immunodeficiency virus gingival enlargement oral cavity plazmablastik lenfoma insan immünyetmezlik virüsü diş eti büyümesi ağız boşluğu |
| title | Plasmablastic Lymphoma in a Previously Undiagnosed Human Immunodeficiency Virus-Positive Patient: A Case Report |
| title_full | Plasmablastic Lymphoma in a Previously Undiagnosed Human Immunodeficiency Virus-Positive Patient: A Case Report |
| title_fullStr | Plasmablastic Lymphoma in a Previously Undiagnosed Human Immunodeficiency Virus-Positive Patient: A Case Report |
| title_full_unstemmed | Plasmablastic Lymphoma in a Previously Undiagnosed Human Immunodeficiency Virus-Positive Patient: A Case Report |
| title_short | Plasmablastic Lymphoma in a Previously Undiagnosed Human Immunodeficiency Virus-Positive Patient: A Case Report |
| title_sort | plasmablastic lymphoma in a previously undiagnosed human immunodeficiency virus positive patient a case report |
| topic | plasmablastic lymphoma human immunodeficiency virus gingival enlargement oral cavity plazmablastik lenfoma insan immünyetmezlik virüsü diş eti büyümesi ağız boşluğu |
| url | https://dergipark.org.tr/tr/download/article-file/2658260 |
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