Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance.
Zonulin is the only physiological mediator known to regulate intestinal permeability reversibly by modulating intercellular tight junctions. To investigate the relationship between intestinal permeability and obesity-associated metabolic disturbances in humans, we aimed to study circulating zonulin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3356365?pdf=render |
| _version_ | 1828374090674601984 |
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| author | José María Moreno-Navarrete Mònica Sabater Francisco Ortega Wifredo Ricart José Manuel Fernández-Real |
| author_facet | José María Moreno-Navarrete Mònica Sabater Francisco Ortega Wifredo Ricart José Manuel Fernández-Real |
| author_sort | José María Moreno-Navarrete |
| collection | DOAJ |
| description | Zonulin is the only physiological mediator known to regulate intestinal permeability reversibly by modulating intercellular tight junctions. To investigate the relationship between intestinal permeability and obesity-associated metabolic disturbances in humans, we aimed to study circulating zonulin according to obesity and insulin resistance. Circulating zonulin (ELISA) was measured in 123 caucasian men in association with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity). Circulating zonulin increased with body mass index (BMI), waist to hip ratio (WHR), fasting insulin, fasting triglycerides, uric acid and IL-6, and negatively correlated with HDL-cholesterol and insulin sensitivity. In multiple regression analysis, insulin sensitivity (p = 0.002) contributed independently to circulating zonulin variance, after controlling for the effects of BMI, fasting triglycerides and age. When circulating IL-6 was added to this model, only BMI (p = 0.01) contributed independently to circulating zonulin variance. In conclusion, the relationship between insulin sensitivity and circulating zonulin might be mediated through the obesity-related circulating IL-6 increase. |
| first_indexed | 2024-04-14T07:28:11Z |
| format | Article |
| id | doaj.art-5c7c66dd527746a59e8cc3d15ff664aa |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T07:28:11Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5c7c66dd527746a59e8cc3d15ff664aa2022-12-22T02:05:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0175e3716010.1371/journal.pone.0037160Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance.José María Moreno-NavarreteMònica SabaterFrancisco OrtegaWifredo RicartJosé Manuel Fernández-RealZonulin is the only physiological mediator known to regulate intestinal permeability reversibly by modulating intercellular tight junctions. To investigate the relationship between intestinal permeability and obesity-associated metabolic disturbances in humans, we aimed to study circulating zonulin according to obesity and insulin resistance. Circulating zonulin (ELISA) was measured in 123 caucasian men in association with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity). Circulating zonulin increased with body mass index (BMI), waist to hip ratio (WHR), fasting insulin, fasting triglycerides, uric acid and IL-6, and negatively correlated with HDL-cholesterol and insulin sensitivity. In multiple regression analysis, insulin sensitivity (p = 0.002) contributed independently to circulating zonulin variance, after controlling for the effects of BMI, fasting triglycerides and age. When circulating IL-6 was added to this model, only BMI (p = 0.01) contributed independently to circulating zonulin variance. In conclusion, the relationship between insulin sensitivity and circulating zonulin might be mediated through the obesity-related circulating IL-6 increase.http://europepmc.org/articles/PMC3356365?pdf=render |
| spellingShingle | José María Moreno-Navarrete Mònica Sabater Francisco Ortega Wifredo Ricart José Manuel Fernández-Real Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance. PLoS ONE |
| title | Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance. |
| title_full | Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance. |
| title_fullStr | Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance. |
| title_full_unstemmed | Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance. |
| title_short | Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance. |
| title_sort | circulating zonulin a marker of intestinal permeability is increased in association with obesity associated insulin resistance |
| url | http://europepmc.org/articles/PMC3356365?pdf=render |
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