Trajectories of Immediate and Delayed Verbal Memory in the Spanish General Population of Middle-aged and Older Adults
(1) Cognitive decline differs among individuals and cognition function domains. We sought to identify distinct groups of immediate and delayed verbal memory in two age subsamples (50–64, 65+ years), and to analyze associated factors. (2) Latent class mixed models were used to identify verbal memory...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-04-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/10/4/249 |
| _version_ | 1797569938101108736 |
|---|---|
| author | Ivet Bayes-Marin Daniel Fernández Elvira Lara Natalia Martín-María Marta Miret Darío Moreno-Agostino José Luis Ayuso-Mateos Albert Sanchez-Niubo Josep Maria Haro Beatriz Olaya |
| author_facet | Ivet Bayes-Marin Daniel Fernández Elvira Lara Natalia Martín-María Marta Miret Darío Moreno-Agostino José Luis Ayuso-Mateos Albert Sanchez-Niubo Josep Maria Haro Beatriz Olaya |
| author_sort | Ivet Bayes-Marin |
| collection | DOAJ |
| description | (1) Cognitive decline differs among individuals and cognition function domains. We sought to identify distinct groups of immediate and delayed verbal memory in two age subsamples (50–64, 65+ years), and to analyze associated factors. (2) Latent class mixed models were used to identify verbal memory trajectories in a sample of Spanish community-dwelling individuals over 8 years’ follow up. Chi-square and Kruskal–Wallis tests were used to assess differences among trajectories. (3) Different trajectories were identified. In the case of immediate verbal memory, these were: very low/decline (6.3%), low/stable (38.2%), medium/slow decline (43.4%), and high/slow decline (12.2%) in the middle-aged group, and low/decline (20.4%), medium/slow decline (60.4%), and high/slow decline (19.2%) in the older subsample. In delayed verbal memory, more distinct patterns were found: very low/decline (12.4%), low/stable (51.4%), medium/accelerated decline (24.7%), and high/slow increase (11.4%) in the younger group, and low/slow decline (34.4%), medium/decline (52.7%), and high/slow decline (12.9%) in the older group. (4) Overall, low initial performance and decline were associated with older age, lower education, and higher diabetes/stroke prevalence. Differences found suggests heterogeneity in cognitive ageing. The high prevalence of cardiovascular diseases in those with worse cognition suggests that early interventions to prevent those conditions should be targeted in midlife to delay cognitive decline. |
| first_indexed | 2024-03-10T20:18:18Z |
| format | Article |
| id | doaj.art-5c7d501b6e4d499bbdfbcc5964f8f80e |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T20:18:18Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-5c7d501b6e4d499bbdfbcc5964f8f80e2023-11-19T22:23:56ZengMDPI AGBrain Sciences2076-34252020-04-0110424910.3390/brainsci10040249Trajectories of Immediate and Delayed Verbal Memory in the Spanish General Population of Middle-aged and Older AdultsIvet Bayes-Marin0Daniel Fernández1Elvira Lara2Natalia Martín-María3Marta Miret4Darío Moreno-Agostino5José Luis Ayuso-Mateos6Albert Sanchez-Niubo7Josep Maria Haro8Beatriz Olaya9Research, Innovation and Teaching Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, 08830 Barcelona, SpainResearch, Innovation and Teaching Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, 08830 Barcelona, SpainDepartment of Psychiatry, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), 28006 Madrid, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, SpainResearch, Innovation and Teaching Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, 08830 Barcelona, SpainResearch, Innovation and Teaching Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, 08830 Barcelona, SpainResearch, Innovation and Teaching Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, 08830 Barcelona, Spain(1) Cognitive decline differs among individuals and cognition function domains. We sought to identify distinct groups of immediate and delayed verbal memory in two age subsamples (50–64, 65+ years), and to analyze associated factors. (2) Latent class mixed models were used to identify verbal memory trajectories in a sample of Spanish community-dwelling individuals over 8 years’ follow up. Chi-square and Kruskal–Wallis tests were used to assess differences among trajectories. (3) Different trajectories were identified. In the case of immediate verbal memory, these were: very low/decline (6.3%), low/stable (38.2%), medium/slow decline (43.4%), and high/slow decline (12.2%) in the middle-aged group, and low/decline (20.4%), medium/slow decline (60.4%), and high/slow decline (19.2%) in the older subsample. In delayed verbal memory, more distinct patterns were found: very low/decline (12.4%), low/stable (51.4%), medium/accelerated decline (24.7%), and high/slow increase (11.4%) in the younger group, and low/slow decline (34.4%), medium/decline (52.7%), and high/slow decline (12.9%) in the older group. (4) Overall, low initial performance and decline were associated with older age, lower education, and higher diabetes/stroke prevalence. Differences found suggests heterogeneity in cognitive ageing. The high prevalence of cardiovascular diseases in those with worse cognition suggests that early interventions to prevent those conditions should be targeted in midlife to delay cognitive decline.https://www.mdpi.com/2076-3425/10/4/249cognitioncognitive functionscognitive agingmemoryepidemiology |
| spellingShingle | Ivet Bayes-Marin Daniel Fernández Elvira Lara Natalia Martín-María Marta Miret Darío Moreno-Agostino José Luis Ayuso-Mateos Albert Sanchez-Niubo Josep Maria Haro Beatriz Olaya Trajectories of Immediate and Delayed Verbal Memory in the Spanish General Population of Middle-aged and Older Adults Brain Sciences cognition cognitive functions cognitive aging memory epidemiology |
| title | Trajectories of Immediate and Delayed Verbal Memory in the Spanish General Population of Middle-aged and Older Adults |
| title_full | Trajectories of Immediate and Delayed Verbal Memory in the Spanish General Population of Middle-aged and Older Adults |
| title_fullStr | Trajectories of Immediate and Delayed Verbal Memory in the Spanish General Population of Middle-aged and Older Adults |
| title_full_unstemmed | Trajectories of Immediate and Delayed Verbal Memory in the Spanish General Population of Middle-aged and Older Adults |
| title_short | Trajectories of Immediate and Delayed Verbal Memory in the Spanish General Population of Middle-aged and Older Adults |
| title_sort | trajectories of immediate and delayed verbal memory in the spanish general population of middle aged and older adults |
| topic | cognition cognitive functions cognitive aging memory epidemiology |
| url | https://www.mdpi.com/2076-3425/10/4/249 |
| work_keys_str_mv | AT ivetbayesmarin trajectoriesofimmediateanddelayedverbalmemoryinthespanishgeneralpopulationofmiddleagedandolderadults AT danielfernandez trajectoriesofimmediateanddelayedverbalmemoryinthespanishgeneralpopulationofmiddleagedandolderadults AT elviralara trajectoriesofimmediateanddelayedverbalmemoryinthespanishgeneralpopulationofmiddleagedandolderadults AT nataliamartinmaria trajectoriesofimmediateanddelayedverbalmemoryinthespanishgeneralpopulationofmiddleagedandolderadults AT martamiret trajectoriesofimmediateanddelayedverbalmemoryinthespanishgeneralpopulationofmiddleagedandolderadults AT dariomorenoagostino trajectoriesofimmediateanddelayedverbalmemoryinthespanishgeneralpopulationofmiddleagedandolderadults AT joseluisayusomateos trajectoriesofimmediateanddelayedverbalmemoryinthespanishgeneralpopulationofmiddleagedandolderadults AT albertsanchezniubo trajectoriesofimmediateanddelayedverbalmemoryinthespanishgeneralpopulationofmiddleagedandolderadults AT josepmariaharo trajectoriesofimmediateanddelayedverbalmemoryinthespanishgeneralpopulationofmiddleagedandolderadults AT beatrizolaya trajectoriesofimmediateanddelayedverbalmemoryinthespanishgeneralpopulationofmiddleagedandolderadults |