Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma

Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma

Despite improved survival for children with newly diagnosed neuroblastoma (NB), recurrent disease is a significant problem, with treatment options limited by anti-tumor efficacy, patient drug tolerance, and cumulative toxicity. We previously demonstrated that neural stem cells (NSCs) expressing a mo...

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Bibliographic Details
Main Authors: Margarita Gutova, Leanne Goldstein, Marianne Metz, Anahit Hovsepyan, Lyudmila G. Tsurkan, Revathiswari Tirughana, Lusine Tsaturyan, Alexander J. Annala, Timothy W. Synold, Zesheng Wan, Robert Seeger, Clarke Anderson, Rex A. Moats, Philip M. Potter, Karen S. Aboody
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
neuroblastoma
neural stem cells
NSC
gene therapy
irinotecan
CPT-11
drug delivery
enzyme prodrug
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770516300535

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http://www.sciencedirect.com/science/article/pii/S2372770516300535

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