The RAD51-FFPE Test; Calibration of a Functional Homologous Recombination Deficiency Test on Diagnostic Endometrial and Ovarian Tumor Blocks

The RAD51-FFPE Test; Calibration of a Functional Homologous Recombination Deficiency Test on Diagnostic Endometrial and Ovarian Tumor Blocks

PARP inhibitor (PARPi) sensitivity is related to tumor-specific defects in homologous recombination (HR). Therefore, there is great clinical interest in tests that can rapidly and reliably identify HR deficiency (HRD). Functional HRD tests determine the actual HR status by using the (dis)ability to...

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Bibliographic Details
Main Authors: Lise M. van Wijk, Claire J. H. Kramer, Sylvia Vermeulen, Natalja T. ter Haar, Marthe M. de Jonge, Judith R. Kroep, Cor D. de Kroon, Katja N. Gaarenstroom, Harry Vrieling, Tjalling Bosse, Maaike P. G. Vreeswijk
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
endometrial carcinoma
ovarian carcinoma
homologous recombination deficiency
RECAP test
RAD51-FFPE test
RAD51
Online Access:https://www.mdpi.com/2072-6694/13/12/2994

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