Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2

Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2

Sickle cell anaemia (SCA) is one of the common autosomal recessive monogenic disorders, caused by a transverse point mutation (GAG > GTG) at the sixth codon of the beta-globin gene, which results in haemolytic anaemia due to the fragile RBCs. Recent progress in genome editing has gained atten...

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Bibliographic Details
Main Authors: Anila George, Nithin Sam Ravi, Kirti Prasad, Lokesh Panigrahi, Sanya Koikkara, Vignesh Rajendiran, Nivedhitha Devaraju, Joshua Paul, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Srujan Marepally, Shaji R. Velayudhan, Alok Srivastava, Kumarasamypet M. Mohankumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Genome Editing
Subjects:
prime editing
sickle cell anaemia
CRISPR
haemoglobinopathies
beta-globin
Online Access:https://www.frontiersin.org/articles/10.3389/fgeed.2022.1085111/full

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