Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders.
The identification of growth factors as potential biomarkers in alcohol addiction may help to understand underlying mechanisms associated with the pathogenesis of alcohol use disorders (AUDs). Previous studies have linked growth factors to neural plasticity in neurocognitive impairment and mental di...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5673472?pdf=render |
| _version_ | 1818420226651324416 |
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| author | Nuria García-Marchena Daniel Silva-Peña Ana Isabel Martín-Velasco María Ángeles Villanúa Pedro Araos María Pedraz Rosa Maza-Quiroga Pablo Romero-Sanchiz Gabriel Rubio Estela Castilla-Ortega Juan Suárez Fernando Rodríguez de Fonseca Antonia Serrano Francisco Javier Pavón |
| author_facet | Nuria García-Marchena Daniel Silva-Peña Ana Isabel Martín-Velasco María Ángeles Villanúa Pedro Araos María Pedraz Rosa Maza-Quiroga Pablo Romero-Sanchiz Gabriel Rubio Estela Castilla-Ortega Juan Suárez Fernando Rodríguez de Fonseca Antonia Serrano Francisco Javier Pavón |
| author_sort | Nuria García-Marchena |
| collection | DOAJ |
| description | The identification of growth factors as potential biomarkers in alcohol addiction may help to understand underlying mechanisms associated with the pathogenesis of alcohol use disorders (AUDs). Previous studies have linked growth factors to neural plasticity in neurocognitive impairment and mental disorders. In order to further clarify the impact of chronic alcohol consumption on circulating growth factors, a cross-sectional study was performed in abstinent AUD patients (alcohol group, N = 91) and healthy control subjects (control group, N = 55) to examine plasma concentrations of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and IGF-1 binding protein-3 (IGFBP-3). The association of these plasma peptides with relevant AUD-related variables and psychiatric comorbidity was explored. The alcohol group was diagnosed with severe AUD and showed an average of 13 years of problematic use and 10 months of abstinence at the moment of participating in the study. Regarding common medical conditions associated with AUD, we observed an elevated incidence of alcohol-induced liver and pancreas diseases (18.7%) and psychiatric comorbidity (76.9%). Thus, AUD patients displayed a high prevalence of dual diagnosis (39.3%) [mainly depression (19.9%)] and comorbid substance use disorders (40.7%). Plasma BDNF and IGF-1 concentrations were significantly lower in the alcohol group than in the control group (p<0.001). Remarkably, there was a negative association between IGF-1 concentrations and age in the control group (r = -0.52, p<0.001) that was not found in the alcohol group. Concerning AUD-related variables, AUD patients with liver and pancreas diseases showed even lower concentrations of BDNF (p<0.05). In contrast, the changes in plasma concentrations of these peptides were not associated with abstinence, problematic use, AUD severity or lifetime psychiatric comorbidity. These results suggest that further research is necessary to elucidate the role of BDNF in alcohol-induced toxicity and the biological significance of the lack of correlation between age and plasma IGF-1 levels in abstinent AUD patients. |
| first_indexed | 2024-12-14T12:51:06Z |
| format | Article |
| id | doaj.art-5c80ac25ec9d421cb460c3edd7b70e76 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T12:51:06Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5c80ac25ec9d421cb460c3edd7b70e762022-12-21T23:00:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011211e018763410.1371/journal.pone.0187634Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders.Nuria García-MarchenaDaniel Silva-PeñaAna Isabel Martín-VelascoMaría Ángeles VillanúaPedro AraosMaría PedrazRosa Maza-QuirogaPablo Romero-SanchizGabriel RubioEstela Castilla-OrtegaJuan SuárezFernando Rodríguez de FonsecaAntonia SerranoFrancisco Javier PavónThe identification of growth factors as potential biomarkers in alcohol addiction may help to understand underlying mechanisms associated with the pathogenesis of alcohol use disorders (AUDs). Previous studies have linked growth factors to neural plasticity in neurocognitive impairment and mental disorders. In order to further clarify the impact of chronic alcohol consumption on circulating growth factors, a cross-sectional study was performed in abstinent AUD patients (alcohol group, N = 91) and healthy control subjects (control group, N = 55) to examine plasma concentrations of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and IGF-1 binding protein-3 (IGFBP-3). The association of these plasma peptides with relevant AUD-related variables and psychiatric comorbidity was explored. The alcohol group was diagnosed with severe AUD and showed an average of 13 years of problematic use and 10 months of abstinence at the moment of participating in the study. Regarding common medical conditions associated with AUD, we observed an elevated incidence of alcohol-induced liver and pancreas diseases (18.7%) and psychiatric comorbidity (76.9%). Thus, AUD patients displayed a high prevalence of dual diagnosis (39.3%) [mainly depression (19.9%)] and comorbid substance use disorders (40.7%). Plasma BDNF and IGF-1 concentrations were significantly lower in the alcohol group than in the control group (p<0.001). Remarkably, there was a negative association between IGF-1 concentrations and age in the control group (r = -0.52, p<0.001) that was not found in the alcohol group. Concerning AUD-related variables, AUD patients with liver and pancreas diseases showed even lower concentrations of BDNF (p<0.05). In contrast, the changes in plasma concentrations of these peptides were not associated with abstinence, problematic use, AUD severity or lifetime psychiatric comorbidity. These results suggest that further research is necessary to elucidate the role of BDNF in alcohol-induced toxicity and the biological significance of the lack of correlation between age and plasma IGF-1 levels in abstinent AUD patients.http://europepmc.org/articles/PMC5673472?pdf=render |
| spellingShingle | Nuria García-Marchena Daniel Silva-Peña Ana Isabel Martín-Velasco María Ángeles Villanúa Pedro Araos María Pedraz Rosa Maza-Quiroga Pablo Romero-Sanchiz Gabriel Rubio Estela Castilla-Ortega Juan Suárez Fernando Rodríguez de Fonseca Antonia Serrano Francisco Javier Pavón Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders. PLoS ONE |
| title | Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders. |
| title_full | Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders. |
| title_fullStr | Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders. |
| title_full_unstemmed | Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders. |
| title_short | Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders. |
| title_sort | decreased plasma concentrations of bdnf and igf 1 in abstinent patients with alcohol use disorders |
| url | http://europepmc.org/articles/PMC5673472?pdf=render |
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