Long-term scopolamine treatment altered locomotor, exploratory and anxiety-like behaviours of albino rats
Abstract Background Animal models are used to provide an adequate investigation of brain-behaviour, physiological and path physiological relationships to give insight into human behaviour and the underlying processes of drugs affecting the nervous system. Scopolamine; SCO (alkaloid l-(2)-scopolamine...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-01-01
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| Series: | Beni-Suef University Journal of Basic and Applied Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43088-021-00187-8 |
| _version_ | 1819006799876980736 |
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| author | Asmaa K. Abdelghany Akram M. El-Kashlan Hosny H. Emeash Fatma Khalil |
| author_facet | Asmaa K. Abdelghany Akram M. El-Kashlan Hosny H. Emeash Fatma Khalil |
| author_sort | Asmaa K. Abdelghany |
| collection | DOAJ |
| description | Abstract Background Animal models are used to provide an adequate investigation of brain-behaviour, physiological and path physiological relationships to give insight into human behaviour and the underlying processes of drugs affecting the nervous system. Scopolamine; SCO (alkaloid l-(2)-scopolamine [l-(2)-hyoscine]) has a competitive inhibitory effect on muscarinic receptors for acetylcholine. Thus, this study was designated to investigate the effect of long-term SCO treatment on locomotor, exploratory and anxiety-like behaviours of rats using open field test. Results The long-term SCO treatment induced a prominent increase in locomotion (hyperactivity) and exploratory behaviour of rats. In addition, anxiety-like behavioural patterns showed a non-significant difference in SCO treated compared to control. Serotonin level was significantly decreased in the scopolamine treated group in comparison with the control group. Conclusions Data suggested that long-term SCO treatment resulted in marked neurobehavioural alterations in a rat as an animal model. |
| first_indexed | 2024-12-21T00:14:26Z |
| format | Article |
| id | doaj.art-5c80fe2705724607aa51ab3a48f4dd4e |
| institution | Directory Open Access Journal |
| issn | 2314-8543 |
| language | English |
| last_indexed | 2024-12-21T00:14:26Z |
| publishDate | 2022-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Beni-Suef University Journal of Basic and Applied Sciences |
| spelling | doaj.art-5c80fe2705724607aa51ab3a48f4dd4e2022-12-21T19:22:16ZengSpringerOpenBeni-Suef University Journal of Basic and Applied Sciences2314-85432022-01-011111810.1186/s43088-021-00187-8Long-term scopolamine treatment altered locomotor, exploratory and anxiety-like behaviours of albino ratsAsmaa K. Abdelghany0Akram M. El-Kashlan1Hosny H. Emeash2Fatma Khalil3Animal and Poultry Management and Wealth Development Department, Faculty of Veterinary Medicine, Beni-Suef UniversityBiochemistry Department, Faculty of Pharmacy, University of Sadat CityAnimal and Poultry Management and Wealth Development Department, Faculty of Veterinary Medicine, Beni-Suef UniversityAnimal and Poultry Management and Wealth Development Department, Faculty of Veterinary Medicine, Beni-Suef UniversityAbstract Background Animal models are used to provide an adequate investigation of brain-behaviour, physiological and path physiological relationships to give insight into human behaviour and the underlying processes of drugs affecting the nervous system. Scopolamine; SCO (alkaloid l-(2)-scopolamine [l-(2)-hyoscine]) has a competitive inhibitory effect on muscarinic receptors for acetylcholine. Thus, this study was designated to investigate the effect of long-term SCO treatment on locomotor, exploratory and anxiety-like behaviours of rats using open field test. Results The long-term SCO treatment induced a prominent increase in locomotion (hyperactivity) and exploratory behaviour of rats. In addition, anxiety-like behavioural patterns showed a non-significant difference in SCO treated compared to control. Serotonin level was significantly decreased in the scopolamine treated group in comparison with the control group. Conclusions Data suggested that long-term SCO treatment resulted in marked neurobehavioural alterations in a rat as an animal model.https://doi.org/10.1186/s43088-021-00187-8ScopolamineRatsSerotoninExploratory behaviourLocomotion |
| spellingShingle | Asmaa K. Abdelghany Akram M. El-Kashlan Hosny H. Emeash Fatma Khalil Long-term scopolamine treatment altered locomotor, exploratory and anxiety-like behaviours of albino rats Beni-Suef University Journal of Basic and Applied Sciences Scopolamine Rats Serotonin Exploratory behaviour Locomotion |
| title | Long-term scopolamine treatment altered locomotor, exploratory and anxiety-like behaviours of albino rats |
| title_full | Long-term scopolamine treatment altered locomotor, exploratory and anxiety-like behaviours of albino rats |
| title_fullStr | Long-term scopolamine treatment altered locomotor, exploratory and anxiety-like behaviours of albino rats |
| title_full_unstemmed | Long-term scopolamine treatment altered locomotor, exploratory and anxiety-like behaviours of albino rats |
| title_short | Long-term scopolamine treatment altered locomotor, exploratory and anxiety-like behaviours of albino rats |
| title_sort | long term scopolamine treatment altered locomotor exploratory and anxiety like behaviours of albino rats |
| topic | Scopolamine Rats Serotonin Exploratory behaviour Locomotion |
| url | https://doi.org/10.1186/s43088-021-00187-8 |
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