Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel
Milletia pinnata oil and Nardostachys jatamansi are rich sources of bioactive compounds and have been utilized to formulate various herbal formulations, however, due to certain environmental conditions, pure extract form is prone to degradation. Therefore, in this, study, a green hydrodistillation t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2023.1260165/full |
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| author | Tipare Bhagyashree Devidas Sandip Patil Sandip Patil Minaxi Sharma Nemat Ali Mohammad Khalid Parvez Mohammed S. Al-Dosari Sixi Liu Baskaran Stephen Inbaraj Aarti Bains Feiqiu Wen Feiqiu Wen |
| author_facet | Tipare Bhagyashree Devidas Sandip Patil Sandip Patil Minaxi Sharma Nemat Ali Mohammad Khalid Parvez Mohammed S. Al-Dosari Sixi Liu Baskaran Stephen Inbaraj Aarti Bains Feiqiu Wen Feiqiu Wen |
| author_sort | Tipare Bhagyashree Devidas |
| collection | DOAJ |
| description | Milletia pinnata oil and Nardostachys jatamansi are rich sources of bioactive compounds and have been utilized to formulate various herbal formulations, however, due to certain environmental conditions, pure extract form is prone to degradation. Therefore, in this, study, a green hydrodistillation technology was used to extract M. pinnata oil and N. jatamansi root for the further application in development of pectin crosslinked carboxymethyl cellulose/guar-gum nano hydrogel. Both oil and extract revealed the presence of spirojatamol and hexadecanoic acid methyl ester. Varied concentrations (w/w) of cross-linker and gelling agent were used to formulate oil emulsion extract gel (OEEG1, OEG1, OEEG2, OEG2, OEEG3, OEG3, OEEG4, OEG4, OEEG5, OEG5), in which OEEG2 and OEG2 were found to be stable. The hydrogel displayed an average droplet size of 186.7 nm and a zeta potential of −20.5 mV. Endo and exothermic peaks and the key functional groups including hydroxyl, amide II, and amide III groups confirmed thermal stability and molecular structure. The smooth surface confirmed structural uniformity. Bactericidal activity against both Gram-positive (25.41 ± 0.09 mm) and Gram-negative (27.25 ± 0.01 mm) bacteria and anti-inflammatory activity (49.25%–83.47%) makes nanohydrogel a potential option for treating various infections caused by pathogenic microorganisms. In conclusion, the use of green hydrodistillation technology can be used to extract the bioactive compounds that can be used in formulation of biocompatible and hydrophobic nanohydrogels. Their ability to absorb target-specific drugs makes them a potential option for treating various infections caused by pathogenic microorganisms. |
| first_indexed | 2024-03-12T00:44:06Z |
| format | Article |
| id | doaj.art-5c80fec9ee3147c992b07e0ad6b80acd |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-03-12T00:44:06Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-5c80fec9ee3147c992b07e0ad6b80acd2023-09-14T22:45:31ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462023-09-011110.3389/fchem.2023.12601651260165Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogelTipare Bhagyashree Devidas0Sandip Patil1Sandip Patil2Minaxi Sharma3Nemat Ali4Mohammad Khalid Parvez5Mohammed S. Al-Dosari6Sixi Liu7Baskaran Stephen Inbaraj8Aarti Bains9Feiqiu Wen10Feiqiu Wen11Department of Microbiology, Lovely Professional University, Phagawara, Punjab, IndiaDeparment of Haematology and Oncology, Shenzhen Children’s Hospital, Shenzhen, ChinaShenzhen Institute of Paediatrics, Shenzhen Children’s Hospital, Shenzhen, ChinaHaute Ecole Provinciale de Hainaut–Condorcet, Ath, BelgiumDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaShenzhen Institute of Paediatrics, Shenzhen Children’s Hospital, Shenzhen, ChinaDepartment of Food Science, Fu Jen Catholic University, New Taipei City, TaiwanDepartment of Microbiology, Lovely Professional University, Phagawara, Punjab, IndiaDeparment of Haematology and Oncology, Shenzhen Children’s Hospital, Shenzhen, ChinaShenzhen Institute of Paediatrics, Shenzhen Children’s Hospital, Shenzhen, ChinaMilletia pinnata oil and Nardostachys jatamansi are rich sources of bioactive compounds and have been utilized to formulate various herbal formulations, however, due to certain environmental conditions, pure extract form is prone to degradation. Therefore, in this, study, a green hydrodistillation technology was used to extract M. pinnata oil and N. jatamansi root for the further application in development of pectin crosslinked carboxymethyl cellulose/guar-gum nano hydrogel. Both oil and extract revealed the presence of spirojatamol and hexadecanoic acid methyl ester. Varied concentrations (w/w) of cross-linker and gelling agent were used to formulate oil emulsion extract gel (OEEG1, OEG1, OEEG2, OEG2, OEEG3, OEG3, OEEG4, OEG4, OEEG5, OEG5), in which OEEG2 and OEG2 were found to be stable. The hydrogel displayed an average droplet size of 186.7 nm and a zeta potential of −20.5 mV. Endo and exothermic peaks and the key functional groups including hydroxyl, amide II, and amide III groups confirmed thermal stability and molecular structure. The smooth surface confirmed structural uniformity. Bactericidal activity against both Gram-positive (25.41 ± 0.09 mm) and Gram-negative (27.25 ± 0.01 mm) bacteria and anti-inflammatory activity (49.25%–83.47%) makes nanohydrogel a potential option for treating various infections caused by pathogenic microorganisms. In conclusion, the use of green hydrodistillation technology can be used to extract the bioactive compounds that can be used in formulation of biocompatible and hydrophobic nanohydrogels. Their ability to absorb target-specific drugs makes them a potential option for treating various infections caused by pathogenic microorganisms.https://www.frontiersin.org/articles/10.3389/fchem.2023.1260165/fullgreen hydrodistillationnanohydrogelantimicrobialcarboxymethyl cellulosepectin |
| spellingShingle | Tipare Bhagyashree Devidas Sandip Patil Sandip Patil Minaxi Sharma Nemat Ali Mohammad Khalid Parvez Mohammed S. Al-Dosari Sixi Liu Baskaran Stephen Inbaraj Aarti Bains Feiqiu Wen Feiqiu Wen Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel Frontiers in Chemistry green hydrodistillation nanohydrogel antimicrobial carboxymethyl cellulose pectin |
| title | Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel |
| title_full | Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel |
| title_fullStr | Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel |
| title_full_unstemmed | Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel |
| title_short | Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel |
| title_sort | green extraction of milletia pinnata oil for the development and characterization of pectin crosslinked carboxymethyl cellulose guar gum herbal nano hydrogel |
| topic | green hydrodistillation nanohydrogel antimicrobial carboxymethyl cellulose pectin |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2023.1260165/full |
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