| Summary: | Key Clinical Message The reported case was the fourth instance of MF‐FM transsexual non‐twin siblings, and their father had pedophilia. Further studies are needed to evaluate whether there is a genetic link between gender dysphoria (GD) and pedophilic disorder. Abstract Gender dysphoria (GD) refers to a persistent incongruence between a person's experienced gender and assigned gender, causing discomfort or distress. Family studies and reports of GD co‐occurrence in a family can help clarify whether GD is a familial phenomenon. In this case report, a male‐to‐female (MTF) and female‐to‐male (FTM) transsexual sibling pair with a father with pedophilia was presented, which is a rare occurrence. More research is necessary to understand the potential genetic connection between GD and pedophilia.
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