Epidemiology of cryptococcal meningitis in the US: 1997-2009.
Cryptococcal meningitis (CM) causes significant morbidity and mortality globally; however, recent national trends have not been described. Incidence and trends for CM-associated hospitalizations in 18 states were estimated using the Agency for Healthcare and Research Quality (AHRQ) State Inpatient D...
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| Format: | Article |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3574138?pdf=render |
| _version_ | 1818158722174681088 |
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| author | Vasilios Pyrgos Amy E Seitz Claudia A Steiner D Rebecca Prevots Peter R Williamson |
| author_facet | Vasilios Pyrgos Amy E Seitz Claudia A Steiner D Rebecca Prevots Peter R Williamson |
| author_sort | Vasilios Pyrgos |
| collection | DOAJ |
| description | Cryptococcal meningitis (CM) causes significant morbidity and mortality globally; however, recent national trends have not been described. Incidence and trends for CM-associated hospitalizations in 18 states were estimated using the Agency for Healthcare and Research Quality (AHRQ) State Inpatient Databases (SID) datasets for 1997 through 2009. We identified 30,840 hospitalizations coded for CM, of which 21.6% were among HIV-uninfected patients. CM in-hospital mortality was significant (12.4% for women and 10.8% for men) with a total of 3,440 deaths over the study period. Co-morbidities of CM coded at increased frequency in HIV-uninfected CM hospitalized populations included hydrocephalus and acute/chronic renal failure as well as possible predispositions including transplantation, combined T and B cell defects, Cushing's syndrome, liver disease and hypogammaglobulinemia. Median hospitalization costs were significant for CM and higher for HIV-uninfected patients (16,803.01 vs. 15,708.07; p<0.0001). Cryptococcal meningitis remains a disease with significant morbidity and mortality in the U.S. and the relative burden among persons without HIV infection is increasing. |
| first_indexed | 2024-12-11T15:34:36Z |
| format | Article |
| id | doaj.art-5c841fef673342cfb370eb85a850b7bf |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T15:34:36Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-5c841fef673342cfb370eb85a850b7bf2022-12-22T00:59:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5626910.1371/journal.pone.0056269Epidemiology of cryptococcal meningitis in the US: 1997-2009.Vasilios PyrgosAmy E SeitzClaudia A SteinerD Rebecca PrevotsPeter R WilliamsonCryptococcal meningitis (CM) causes significant morbidity and mortality globally; however, recent national trends have not been described. Incidence and trends for CM-associated hospitalizations in 18 states were estimated using the Agency for Healthcare and Research Quality (AHRQ) State Inpatient Databases (SID) datasets for 1997 through 2009. We identified 30,840 hospitalizations coded for CM, of which 21.6% were among HIV-uninfected patients. CM in-hospital mortality was significant (12.4% for women and 10.8% for men) with a total of 3,440 deaths over the study period. Co-morbidities of CM coded at increased frequency in HIV-uninfected CM hospitalized populations included hydrocephalus and acute/chronic renal failure as well as possible predispositions including transplantation, combined T and B cell defects, Cushing's syndrome, liver disease and hypogammaglobulinemia. Median hospitalization costs were significant for CM and higher for HIV-uninfected patients (16,803.01 vs. 15,708.07; p<0.0001). Cryptococcal meningitis remains a disease with significant morbidity and mortality in the U.S. and the relative burden among persons without HIV infection is increasing.http://europepmc.org/articles/PMC3574138?pdf=render |
| spellingShingle | Vasilios Pyrgos Amy E Seitz Claudia A Steiner D Rebecca Prevots Peter R Williamson Epidemiology of cryptococcal meningitis in the US: 1997-2009. PLoS ONE |
| title | Epidemiology of cryptococcal meningitis in the US: 1997-2009. |
| title_full | Epidemiology of cryptococcal meningitis in the US: 1997-2009. |
| title_fullStr | Epidemiology of cryptococcal meningitis in the US: 1997-2009. |
| title_full_unstemmed | Epidemiology of cryptococcal meningitis in the US: 1997-2009. |
| title_short | Epidemiology of cryptococcal meningitis in the US: 1997-2009. |
| title_sort | epidemiology of cryptococcal meningitis in the us 1997 2009 |
| url | http://europepmc.org/articles/PMC3574138?pdf=render |
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