Innate Immune Tolerance in Microglia Does Not Impact on Central Nervous System Prion Disease

Innate Immune Tolerance in Microglia Does Not Impact on Central Nervous System Prion Disease

Prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, and scrapie in sheep, are infectious and chronic neurodegenerative diseases to which there are no cures. Infection with prions in the central nervous system (CNS) ultimately causes extensive neuro...

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Bibliographic Details
Main Authors: Reiss Pal, Barry M. Bradford, Neil A. Mabbott
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
microglia
prion disease
central nervous system
lipopolysaccharide
innate immune tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.918883/full

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