Meta-analysis of early-life antibiotic use and allergic rhinitis
This meta-analysis aimed to investigate the correlation between early-life antibiotic use and allergic rhinitis. PubMed, Embase, and the Cochrane Central Register of Controlled Trials databases were searched for available studies. Eighteen studies covering 1,768,874 children were included. Early-lif...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-11-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2022-0459 |
| _version_ | 1817967934433132544 |
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| author | Liu Xiang Wu Rongrong Fu Yong Chen Wenxin Chen Yang Yan Yangyan Bi Jing Liu Jia |
| author_facet | Liu Xiang Wu Rongrong Fu Yong Chen Wenxin Chen Yang Yan Yangyan Bi Jing Liu Jia |
| author_sort | Liu Xiang |
| collection | DOAJ |
| description | This meta-analysis aimed to investigate the correlation between early-life antibiotic use and allergic rhinitis. PubMed, Embase, and the Cochrane Central Register of Controlled Trials databases were searched for available studies. Eighteen studies covering 1,768,874 children were included. Early-life antibiotics were associated with an increased incidence of allergic rhinitis (effect size (ES) = 5.00, 95% confidence interval [CI]: 4.88–5.13; I
2 = 95.7%, P
heterogeneity <0.001). In Asia, Europe, and the USA, the incidence of allergic rhinitis in the antibiotic group was higher than that in the no medication group (Asia: ES = 3.68, 95% CI: 3.38–4.01; Europe: ES = 3.20, 95% CI: 3.00–3.42; USA: ES = 3.68, 95% CI: 2.74–4.95). Compared with the no medication group, children who received antibiotics in the first 1 week of life (ES = 5.75, 95% CI: 2.18–15.18), first 1 year of life (ES = 3.37, 95% CI: 3.20–3.55; I
2 = 64.2%, P
heterogeneity = 0.001), or first 3 years of life (ES = 5.21, 95% CI: 2.42–11.19) had a higher incidence of allergic rhinitis. No individual study influenced the estimates of the meta-analysis. The funnel plot showed moderate symmetry and low publication bias. In conclusion, the use of antibiotics in early life was associated with allergic rhinitis. Still, most included studies analyzed antibiotic exposure as a dichotomous variable, without information on the type and dosage of antibiotics. |
| first_indexed | 2024-04-13T12:54:48Z |
| format | Article |
| id | doaj.art-5c87e94b424d4940bbf2dfc1df3f9dfd |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-13T12:54:48Z |
| publishDate | 2022-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-5c87e94b424d4940bbf2dfc1df3f9dfd2022-12-22T02:46:05ZengDe GruyterOpen Medicine2391-54632022-11-011711760177210.1515/med-2022-0459Meta-analysis of early-life antibiotic use and allergic rhinitisLiu Xiang0Wu Rongrong1Fu Yong2Chen Wenxin3Chen Yang4Yan Yangyan5Bi Jing6Liu Jia7Department of ENT and Head & Neck Surgery, Hangzhou First Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, 310003, Zhejiang, ChinaDepartment of ENT and Head & Neck Surgery, The Children’s Hospital Zhejiang University School of Medicine, 3333 Bingsheng Road, Hangzhou, 310051, Zhejiang, ChinaDepartment of ENT and Head & Neck Surgery, The Children’s Hospital Zhejiang University School of Medicine, 3333 Bingsheng Road, Hangzhou, 310051, Zhejiang, ChinaDepartment of ENT and Head & Neck Surgery, The Children’s Hospital Zhejiang University School of Medicine, 3333 Bingsheng Road, Hangzhou, 310051, Zhejiang, ChinaDepartment of ENT and Head & Neck Surgery, The Children’s Hospital Zhejiang University School of Medicine, 3333 Bingsheng Road, Hangzhou, 310051, Zhejiang, ChinaDepartment of ENT and Head & Neck Surgery, The Children’s Hospital Zhejiang University School of Medicine, 3333 Bingsheng Road, Hangzhou, 310051, Zhejiang, ChinaDepartment of ENT and Head & Neck Surgery, The Children’s Hospital Zhejiang University School of Medicine, 3333 Bingsheng Road, Hangzhou, 310051, Zhejiang, ChinaDepartment of ENT and Head & Neck Surgery, The Children’s Hospital Zhejiang University School of Medicine, 3333 Bingsheng Road, Hangzhou, 310051, Zhejiang, ChinaThis meta-analysis aimed to investigate the correlation between early-life antibiotic use and allergic rhinitis. PubMed, Embase, and the Cochrane Central Register of Controlled Trials databases were searched for available studies. Eighteen studies covering 1,768,874 children were included. Early-life antibiotics were associated with an increased incidence of allergic rhinitis (effect size (ES) = 5.00, 95% confidence interval [CI]: 4.88–5.13; I 2 = 95.7%, P heterogeneity <0.001). In Asia, Europe, and the USA, the incidence of allergic rhinitis in the antibiotic group was higher than that in the no medication group (Asia: ES = 3.68, 95% CI: 3.38–4.01; Europe: ES = 3.20, 95% CI: 3.00–3.42; USA: ES = 3.68, 95% CI: 2.74–4.95). Compared with the no medication group, children who received antibiotics in the first 1 week of life (ES = 5.75, 95% CI: 2.18–15.18), first 1 year of life (ES = 3.37, 95% CI: 3.20–3.55; I 2 = 64.2%, P heterogeneity = 0.001), or first 3 years of life (ES = 5.21, 95% CI: 2.42–11.19) had a higher incidence of allergic rhinitis. No individual study influenced the estimates of the meta-analysis. The funnel plot showed moderate symmetry and low publication bias. In conclusion, the use of antibiotics in early life was associated with allergic rhinitis. Still, most included studies analyzed antibiotic exposure as a dichotomous variable, without information on the type and dosage of antibiotics.https://doi.org/10.1515/med-2022-0459antibioticsallergic rhinitisearly lifemeta-analysis |
| spellingShingle | Liu Xiang Wu Rongrong Fu Yong Chen Wenxin Chen Yang Yan Yangyan Bi Jing Liu Jia Meta-analysis of early-life antibiotic use and allergic rhinitis Open Medicine antibiotics allergic rhinitis early life meta-analysis |
| title | Meta-analysis of early-life antibiotic use and allergic rhinitis |
| title_full | Meta-analysis of early-life antibiotic use and allergic rhinitis |
| title_fullStr | Meta-analysis of early-life antibiotic use and allergic rhinitis |
| title_full_unstemmed | Meta-analysis of early-life antibiotic use and allergic rhinitis |
| title_short | Meta-analysis of early-life antibiotic use and allergic rhinitis |
| title_sort | meta analysis of early life antibiotic use and allergic rhinitis |
| topic | antibiotics allergic rhinitis early life meta-analysis |
| url | https://doi.org/10.1515/med-2022-0459 |
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