Airflow limitation as a risk factor for low bone mineral density and hip fracture
Aim: To investigate whether airflow limitation is associated with bone mineral density (BMD) and risk of hip fractures. Methods: A community sample of 5,100 subjects 47–48 and 71–73 years old and living in Bergen was invited. Participants filled in questionnaires and performed a post-bronchodilator...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2016-10-01
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| Series: | European Clinical Respiratory Journal |
| Subjects: | |
| Online Access: | http://www.ecrj.net/index.php/ecrj/article/view/32214/49126 |
| _version_ | 1819154389713027072 |
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| author | Trine Herland Ellen M Apalset Geir Egil Eide Grethe S Tell Sverre Lehmann |
| author_facet | Trine Herland Ellen M Apalset Geir Egil Eide Grethe S Tell Sverre Lehmann |
| author_sort | Trine Herland |
| collection | DOAJ |
| description | Aim: To investigate whether airflow limitation is associated with bone mineral density (BMD) and risk of hip fractures. Methods: A community sample of 5,100 subjects 47–48 and 71–73 years old and living in Bergen was invited. Participants filled in questionnaires and performed a post-bronchodilator spirometry measuring forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC). All attendants were invited to have a BMD measurement of the hip. During 10 years of follow-up, information on death was collected from the Norwegian Cause of Death Registry, and incident hip fractures were registered from regional hospital records of discharge diagnoses and surgical procedure codes. Results: The attendance rate was 69% (n=3,506). The prevalence of chronic obstructive pulmonary disease (COPD) (FEV1/FVC<0.7) was 9%. In multiple logistic regression, the lowest quartile of BMD versus the three upper was significantly predicted by FEV1/FVC<0.7 and FEV1% predicted (odds ratio [OR]: 1.58, 95% confidence interval [CI]: 1.11 to 2.25, and OR per increase of 10%: 0.92, 95% CI: 0.86 to 0.99, respectively). Hip fracture occurred in 126 (4%) participants. In a Cox regression analysis, FEV1% predicted was associated with a lowered risk of hip fracture (hazard ratio per increase of 10%: 0.89, 95% CI: 0.79 to 0.997). Conclusion: Airflow limitation is positively associated with low BMD and risk of hip fracture in middle-aged and elderly. |
| first_indexed | 2024-12-22T15:20:19Z |
| format | Article |
| id | doaj.art-5c882392af3b4bbc8e7da7842816f585 |
| institution | Directory Open Access Journal |
| issn | 2001-8525 |
| language | English |
| last_indexed | 2024-12-22T15:20:19Z |
| publishDate | 2016-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | European Clinical Respiratory Journal |
| spelling | doaj.art-5c882392af3b4bbc8e7da7842816f5852022-12-21T18:21:38ZengTaylor & Francis GroupEuropean Clinical Respiratory Journal2001-85252016-10-01301810.3402/ecrj.v3.3221432214Airflow limitation as a risk factor for low bone mineral density and hip fractureTrine Herland0Ellen M Apalset1Geir Egil Eide2Grethe S Tell3Sverre Lehmann4 Department of Clinical Science, University of Bergen, Bergen, Norway Department of Rheumatology, Haukeland University Hospital, Bergen, Norway Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway Department of Clinical Science, University of Bergen, Bergen, NorwayAim: To investigate whether airflow limitation is associated with bone mineral density (BMD) and risk of hip fractures. Methods: A community sample of 5,100 subjects 47–48 and 71–73 years old and living in Bergen was invited. Participants filled in questionnaires and performed a post-bronchodilator spirometry measuring forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC). All attendants were invited to have a BMD measurement of the hip. During 10 years of follow-up, information on death was collected from the Norwegian Cause of Death Registry, and incident hip fractures were registered from regional hospital records of discharge diagnoses and surgical procedure codes. Results: The attendance rate was 69% (n=3,506). The prevalence of chronic obstructive pulmonary disease (COPD) (FEV1/FVC<0.7) was 9%. In multiple logistic regression, the lowest quartile of BMD versus the three upper was significantly predicted by FEV1/FVC<0.7 and FEV1% predicted (odds ratio [OR]: 1.58, 95% confidence interval [CI]: 1.11 to 2.25, and OR per increase of 10%: 0.92, 95% CI: 0.86 to 0.99, respectively). Hip fracture occurred in 126 (4%) participants. In a Cox regression analysis, FEV1% predicted was associated with a lowered risk of hip fracture (hazard ratio per increase of 10%: 0.89, 95% CI: 0.79 to 0.997). Conclusion: Airflow limitation is positively associated with low BMD and risk of hip fracture in middle-aged and elderly.http://www.ecrj.net/index.php/ecrj/article/view/32214/49126lung functionbone mineral densityhip fractureairflow limitationpopulation study |
| spellingShingle | Trine Herland Ellen M Apalset Geir Egil Eide Grethe S Tell Sverre Lehmann Airflow limitation as a risk factor for low bone mineral density and hip fracture European Clinical Respiratory Journal lung function bone mineral density hip fracture airflow limitation population study |
| title | Airflow limitation as a risk factor for low bone mineral density and hip fracture |
| title_full | Airflow limitation as a risk factor for low bone mineral density and hip fracture |
| title_fullStr | Airflow limitation as a risk factor for low bone mineral density and hip fracture |
| title_full_unstemmed | Airflow limitation as a risk factor for low bone mineral density and hip fracture |
| title_short | Airflow limitation as a risk factor for low bone mineral density and hip fracture |
| title_sort | airflow limitation as a risk factor for low bone mineral density and hip fracture |
| topic | lung function bone mineral density hip fracture airflow limitation population study |
| url | http://www.ecrj.net/index.php/ecrj/article/view/32214/49126 |
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