Exosomes derived from LPS-preconditioned bone marrow-derived MSC modulate macrophage plasticity to promote allograft survival via the NF-κB/NLRP3 signaling pathway

Exosomes derived from LPS-preconditioned bone marrow-derived MSC modulate macrophage plasticity to promote allograft survival via the NF-κB/NLRP3 signaling pathway

Abstract Objectives This study investigated whether exosomes from LPS pretreated bone marrow mesenchymal stem cells (LPS pre-MSCs) could prolong skin graft survival. Methods The exosomes were isolated from the supernatant of MSCs pretreated with LPS. LPS pre-Exo and rapamycin were injected via the t...

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Bibliographic Details
Main Authors: PeiYao Zhang, Panfeng Wu, Umar Zeb Khan, Zekun Zhou, Xinlei Sui, Cheng Li, Kangkang Dong, Yongjun Liu, Liming Qing, Juyu Tang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Nanobiotechnology
Subjects:
Mesenchymal stromal cells
LPS preconditioning
Exosome
Macrophage polarization
Allograft
Online Access:https://doi.org/10.1186/s12951-023-02087-8

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