Epigenetics of obesity
The pathophysiology of obesity is complex and includes changes in eating behavior, genetic, epigenetic, environmental factors, and much more. To date, ~40 genetic polymorphisms are associated with obesity and fat distribution. However, since these options do not fully explain the inheritance of obes...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2020-12-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2632 |
| _version_ | 1797882392301535232 |
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| author | O. M. Drapkina O. T. Kim |
| author_facet | O. M. Drapkina O. T. Kim |
| author_sort | O. M. Drapkina |
| collection | DOAJ |
| description | The pathophysiology of obesity is complex and includes changes in eating behavior, genetic, epigenetic, environmental factors, and much more. To date, ~40 genetic polymorphisms are associated with obesity and fat distribution. However, since these options do not fully explain the inheritance of obesity, other options, such as epigenetic changes, need to be considered. Epigenetic modifications affect gene expression without changing the deoxyribonucleic acid sequence. In addition, environmental exposure during critical periods of development can affect the epigenetic tags and lead to obesity. A deeper understanding of the epigenetic mechanisms underlying obesity can aid in prevention based on lifestyle changes. This review focuses on the role of epigenetic modifications in the development of obesity and related conditions. |
| first_indexed | 2024-04-10T03:35:03Z |
| format | Article |
| id | doaj.art-5c8c0b362fdb4f18b2307cf2efdbd870 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:35:03Z |
| publishDate | 2020-12-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-5c8c0b362fdb4f18b2307cf2efdbd8702023-03-13T07:23:29Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252020-12-0119610.15829/1728-8800-2020-26322190Epigenetics of obesityO. M. Drapkina0O. T. Kim1ФГБУ “Национальный медицинский исследовательский центр терапии и профилактической медицины” Минздрава РоссииФГБУ “Национальный медицинский исследовательский центр терапии и профилактической медицины” Минздрава РоссииThe pathophysiology of obesity is complex and includes changes in eating behavior, genetic, epigenetic, environmental factors, and much more. To date, ~40 genetic polymorphisms are associated with obesity and fat distribution. However, since these options do not fully explain the inheritance of obesity, other options, such as epigenetic changes, need to be considered. Epigenetic modifications affect gene expression without changing the deoxyribonucleic acid sequence. In addition, environmental exposure during critical periods of development can affect the epigenetic tags and lead to obesity. A deeper understanding of the epigenetic mechanisms underlying obesity can aid in prevention based on lifestyle changes. This review focuses on the role of epigenetic modifications in the development of obesity and related conditions.https://cardiovascular.elpub.ru/jour/article/view/2632ожирениеэпигенетикагенетикаметилирование дезоксирибонуклеиновой кислоты |
| spellingShingle | O. M. Drapkina O. T. Kim Epigenetics of obesity Кардиоваскулярная терапия и профилактика ожирение эпигенетика генетика метилирование дезоксирибонуклеиновой кислоты |
| title | Epigenetics of obesity |
| title_full | Epigenetics of obesity |
| title_fullStr | Epigenetics of obesity |
| title_full_unstemmed | Epigenetics of obesity |
| title_short | Epigenetics of obesity |
| title_sort | epigenetics of obesity |
| topic | ожирение эпигенетика генетика метилирование дезоксирибонуклеиновой кислоты |
| url | https://cardiovascular.elpub.ru/jour/article/view/2632 |
| work_keys_str_mv | AT omdrapkina epigeneticsofobesity AT otkim epigeneticsofobesity |