Dual-time-point myocardial 18F-FDG imaging in the detection of coronary artery disease
Abstract Background Myocardial 18F-deoxyglucose (18F-FDG) uptake has been observed to be enhanced in patients with coronary artery disease (CAD) under fasting conditions. However, whether the increased 18F-FDG is induced by myocardial ischemia and how to discriminate ischemic from physiological 18F-...
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12872-017-0554-x |
| _version_ | 1811307944583626752 |
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| author | Ke-Fei Dou Xiao-Jin Gao Bo-Qia Xie Yan Li Zuo-Xiang He Min-Fu Yang |
| author_facet | Ke-Fei Dou Xiao-Jin Gao Bo-Qia Xie Yan Li Zuo-Xiang He Min-Fu Yang |
| author_sort | Ke-Fei Dou |
| collection | DOAJ |
| description | Abstract Background Myocardial 18F-deoxyglucose (18F-FDG) uptake has been observed to be enhanced in patients with coronary artery disease (CAD) under fasting conditions. However, whether the increased 18F-FDG is induced by myocardial ischemia and how to discriminate ischemic from physiological 18F-FDG uptake have rarely been investigated. Methods Under fasting conditions, 18F-FDG PET imaging was performed in 52 patients with suspected CAD. Two 18F-FDG imaging sessions were conducted within two hours after a single administration of 18F-FDG (dual-time-point imaging), and with an intervention of an exercise test after the first imaging. Abnormal 18F-FDG uptake was determined by the classification of the 18F-FDG distribution pattern, and the changes of the 18F-FDG distribution between the two PET imaging sessions were analyzed. 99mTc-sestamibi was injected at peak exercise and myocardial perfusion imaging (MPI) was conducted after 18F-FDG imaging. Coronary angiography was considered the reference for diagnosing CAD. Results Overall, 54.8% (17/31) of CAD patients and 36.2% (21/58) of stenotic coronaries showed exercise-induced abnormal uptake of 18F-FDG. Based on the classification of the 18F-FDG distribution pattern, the sensitivity and specificity of exercise 18F-FDG imaging to diagnose CAD was 80.6% and 95.2% by patient analysis, 56.9% and 98.0% by vascular analysis, respectively. Compared with MPI, 18F-FDG imaging had a tendency to have higher sensitivity (80.6% vs 64.5%, P = 0.06) on the patient level. Conclusion Myocardial ischemia can induce 18F-FDG uptake. With the classification of the 18F-FDG distribution pattern, dual-time-point 18F-FDG imaging under fasting conditions is efficient in diagnosing CAD. |
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| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-13T09:13:23Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-5c8d5a00fe11479bb4f06b19de40cd042022-12-22T02:52:48ZengBMCBMC Cardiovascular Disorders1471-22612017-05-0117111010.1186/s12872-017-0554-xDual-time-point myocardial 18F-FDG imaging in the detection of coronary artery diseaseKe-Fei Dou0Xiao-Jin Gao1Bo-Qia Xie2Yan Li3Zuo-Xiang He4Min-Fu Yang5State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Cardiovascular Institute, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular Disease, Department of Cardiology, Cardiovascular Institute, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cardiology, Beijing Chaoyang Hospital, Capital Medical UniversityDepartment of Nuclear Medicine, Cardiovascular Institute, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Nuclear Medicine, Cardiovascular Institute, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Nuclear Medicine, Beijing Chaoyang Hospital, Capital Medical UniversityAbstract Background Myocardial 18F-deoxyglucose (18F-FDG) uptake has been observed to be enhanced in patients with coronary artery disease (CAD) under fasting conditions. However, whether the increased 18F-FDG is induced by myocardial ischemia and how to discriminate ischemic from physiological 18F-FDG uptake have rarely been investigated. Methods Under fasting conditions, 18F-FDG PET imaging was performed in 52 patients with suspected CAD. Two 18F-FDG imaging sessions were conducted within two hours after a single administration of 18F-FDG (dual-time-point imaging), and with an intervention of an exercise test after the first imaging. Abnormal 18F-FDG uptake was determined by the classification of the 18F-FDG distribution pattern, and the changes of the 18F-FDG distribution between the two PET imaging sessions were analyzed. 99mTc-sestamibi was injected at peak exercise and myocardial perfusion imaging (MPI) was conducted after 18F-FDG imaging. Coronary angiography was considered the reference for diagnosing CAD. Results Overall, 54.8% (17/31) of CAD patients and 36.2% (21/58) of stenotic coronaries showed exercise-induced abnormal uptake of 18F-FDG. Based on the classification of the 18F-FDG distribution pattern, the sensitivity and specificity of exercise 18F-FDG imaging to diagnose CAD was 80.6% and 95.2% by patient analysis, 56.9% and 98.0% by vascular analysis, respectively. Compared with MPI, 18F-FDG imaging had a tendency to have higher sensitivity (80.6% vs 64.5%, P = 0.06) on the patient level. Conclusion Myocardial ischemia can induce 18F-FDG uptake. With the classification of the 18F-FDG distribution pattern, dual-time-point 18F-FDG imaging under fasting conditions is efficient in diagnosing CAD.http://link.springer.com/article/10.1186/s12872-017-0554-xDual-time-point imaging18F-FDGCoronary artery diseaseMyocardial ischemia |
| spellingShingle | Ke-Fei Dou Xiao-Jin Gao Bo-Qia Xie Yan Li Zuo-Xiang He Min-Fu Yang Dual-time-point myocardial 18F-FDG imaging in the detection of coronary artery disease BMC Cardiovascular Disorders Dual-time-point imaging 18F-FDG Coronary artery disease Myocardial ischemia |
| title | Dual-time-point myocardial 18F-FDG imaging in the detection of coronary artery disease |
| title_full | Dual-time-point myocardial 18F-FDG imaging in the detection of coronary artery disease |
| title_fullStr | Dual-time-point myocardial 18F-FDG imaging in the detection of coronary artery disease |
| title_full_unstemmed | Dual-time-point myocardial 18F-FDG imaging in the detection of coronary artery disease |
| title_short | Dual-time-point myocardial 18F-FDG imaging in the detection of coronary artery disease |
| title_sort | dual time point myocardial 18f fdg imaging in the detection of coronary artery disease |
| topic | Dual-time-point imaging 18F-FDG Coronary artery disease Myocardial ischemia |
| url | http://link.springer.com/article/10.1186/s12872-017-0554-x |
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