Novel poly(butylene succinate) nanocomposites containing strontium hydroxyapatite nanorods with enhanced osteoconductivity for tissue engineering applications
Three series of poly(butylene succinate) (PBSu) nanocomposites containing 0.5, 1 and 2.5 wt% strontium hydroxyapatite [Sr5(PO4)3OH] nanorods (SrHAp nrds) were prepared by in situ polymerisation. The structural effects of Sr5(PO4)3OH nanorods, for the different concentrations, inside the polymeric ma...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Budapest University of Technology
2015-09-01
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| Series: | eXPRESS Polymer Letters |
| Subjects: | |
| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0006103&mi=cd |
| _version_ | 1818060984095342592 |
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| author | M. Nerantzaki M. Filippousi G. Van Tendeloo Z. Terzopoulou D. Bikiaris O. M. Goudouri R. Detsch A. Gruenewald A. R. Boccaccini |
| author_facet | M. Nerantzaki M. Filippousi G. Van Tendeloo Z. Terzopoulou D. Bikiaris O. M. Goudouri R. Detsch A. Gruenewald A. R. Boccaccini |
| author_sort | M. Nerantzaki |
| collection | DOAJ |
| description | Three series of poly(butylene succinate) (PBSu) nanocomposites containing 0.5, 1 and 2.5 wt% strontium hydroxyapatite [Sr5(PO4)3OH] nanorods (SrHAp nrds) were prepared by in situ polymerisation. The structural effects of Sr5(PO4)3OH nanorods, for the different concentrations, inside the polymeric matrix (PBSu), were studied through high angle annular dark field scanning transmission electron microscopy (HAADF-STEM). HAADF-STEM measurements revealed that the SrHAp nanorods at low concentrations are dispersed inside the polymeric PBSu matrix while in 1 wt% some aggregates are formed. These aggregations affect the mechanical properties giving an enhancement for the concentration of 0.5 wt% SrHAp nrds in tensile strength, while a reduction is recorded for higher loadings of the nanofiller. Studies on enzymatic hydrolysis revealed that all nanocomposites present higher hydrolysis rates than neat PBSu, indicating that nanorods accelerate the hydrolysis degradation process. In vitro bioactivity tests prove that SrHAp nrds promote the formation of hydroxyapatite on the PBSu surface. All nanocomposites were tested also in relevant cell culture using osteoblast-like cells (MG-63) to demonstrate their biocompatibility showing SrHAp nanorods support cell attachment. |
| first_indexed | 2024-12-10T13:41:06Z |
| format | Article |
| id | doaj.art-5c8d64907d834886aae24d4120cc6bfa |
| institution | Directory Open Access Journal |
| issn | 1788-618X |
| language | English |
| last_indexed | 2024-12-10T13:41:06Z |
| publishDate | 2015-09-01 |
| publisher | Budapest University of Technology |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj.art-5c8d64907d834886aae24d4120cc6bfa2022-12-22T01:46:40ZengBudapest University of TechnologyeXPRESS Polymer Letters1788-618X2015-09-019977378910.3144/expresspolymlett.2015.73Novel poly(butylene succinate) nanocomposites containing strontium hydroxyapatite nanorods with enhanced osteoconductivity for tissue engineering applicationsM. NerantzakiM. FilippousiG. Van TendelooZ. TerzopoulouD. BikiarisO. M. GoudouriR. DetschA. GruenewaldA. R. BoccacciniThree series of poly(butylene succinate) (PBSu) nanocomposites containing 0.5, 1 and 2.5 wt% strontium hydroxyapatite [Sr5(PO4)3OH] nanorods (SrHAp nrds) were prepared by in situ polymerisation. The structural effects of Sr5(PO4)3OH nanorods, for the different concentrations, inside the polymeric matrix (PBSu), were studied through high angle annular dark field scanning transmission electron microscopy (HAADF-STEM). HAADF-STEM measurements revealed that the SrHAp nanorods at low concentrations are dispersed inside the polymeric PBSu matrix while in 1 wt% some aggregates are formed. These aggregations affect the mechanical properties giving an enhancement for the concentration of 0.5 wt% SrHAp nrds in tensile strength, while a reduction is recorded for higher loadings of the nanofiller. Studies on enzymatic hydrolysis revealed that all nanocomposites present higher hydrolysis rates than neat PBSu, indicating that nanorods accelerate the hydrolysis degradation process. In vitro bioactivity tests prove that SrHAp nrds promote the formation of hydroxyapatite on the PBSu surface. All nanocomposites were tested also in relevant cell culture using osteoblast-like cells (MG-63) to demonstrate their biocompatibility showing SrHAp nanorods support cell attachment.http://www.expresspolymlett.com/letolt.php?file=EPL-0006103&mi=cdNanocompositesPoly(butylene succinate)strontium hydroxyapatite nanortissue engineering |
| spellingShingle | M. Nerantzaki M. Filippousi G. Van Tendeloo Z. Terzopoulou D. Bikiaris O. M. Goudouri R. Detsch A. Gruenewald A. R. Boccaccini Novel poly(butylene succinate) nanocomposites containing strontium hydroxyapatite nanorods with enhanced osteoconductivity for tissue engineering applications eXPRESS Polymer Letters Nanocomposites Poly(butylene succinate) strontium hydroxyapatite nanor tissue engineering |
| title | Novel poly(butylene succinate) nanocomposites containing strontium hydroxyapatite nanorods with enhanced osteoconductivity for tissue engineering applications |
| title_full | Novel poly(butylene succinate) nanocomposites containing strontium hydroxyapatite nanorods with enhanced osteoconductivity for tissue engineering applications |
| title_fullStr | Novel poly(butylene succinate) nanocomposites containing strontium hydroxyapatite nanorods with enhanced osteoconductivity for tissue engineering applications |
| title_full_unstemmed | Novel poly(butylene succinate) nanocomposites containing strontium hydroxyapatite nanorods with enhanced osteoconductivity for tissue engineering applications |
| title_short | Novel poly(butylene succinate) nanocomposites containing strontium hydroxyapatite nanorods with enhanced osteoconductivity for tissue engineering applications |
| title_sort | novel poly butylene succinate nanocomposites containing strontium hydroxyapatite nanorods with enhanced osteoconductivity for tissue engineering applications |
| topic | Nanocomposites Poly(butylene succinate) strontium hydroxyapatite nanor tissue engineering |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0006103&mi=cd |
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