Comparison of cholesterol turnover by sterol balance and input–output analysis, and a shortened way to estimate total exchangeable mass of cholesterol by the combination of the two methods
Daily turnover of cholesterol obtained by the balance method was compared to daily input rates calculated by input–output analysis in 43 experiments. The mean value of input rates for kinetic data of 10.1–16.4 weeks' duration (14 experiments) was 1.05 g/day vs. the chemical turnover of 0.94 g/d...
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| Format: | Article |
| Language: | English |
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Elsevier
1978-01-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520415809 |
| _version_ | 1818743058589548544 |
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| author | P Samuel, Dr S Lieberman E H Ahrens, Jr |
| author_facet | P Samuel, Dr S Lieberman E H Ahrens, Jr |
| author_sort | P Samuel, Dr |
| collection | DOAJ |
| description | Daily turnover of cholesterol obtained by the balance method was compared to daily input rates calculated by input–output analysis in 43 experiments. The mean value of input rates for kinetic data of 10.1–16.4 weeks' duration (14 experiments) was 1.05 g/day vs. the chemical turnover of 0.94 g/day (difference 10.9%). For decay curves of 4.8–9.9 weeks' duration (29 experiments) the mean results were 1.67 g/day vs. 1.31 g/day, respectively (difference 20.1%). A combination of the balance method with input-output analysis is proposed to estimate the size of M (minimum value of the total exchangeable mass of cholesterol) in short-term experiments. Using this method, the analysis of curves of 10–12 weeks' duration showed a mean difference of 7.5% with the analysis of curves of 50–66 weeks' duration in 17 patients. However, because of considerable variations that can occur in individual cases, it is urged that a standard correction factor not be used, either in estimating turnover data or M from 10–12 weeks' kinetic data; rather, the proposed combined method will alert the investigator to the occurrence of discrepant results. |
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| format | Article |
| id | doaj.art-5c8d94dbbc874c2391610c97dc6a28dc |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-18T02:22:23Z |
| publishDate | 1978-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-5c8d94dbbc874c2391610c97dc6a28dc2022-12-21T21:24:07ZengElsevierJournal of Lipid Research0022-22751978-01-0119194102Comparison of cholesterol turnover by sterol balance and input–output analysis, and a shortened way to estimate total exchangeable mass of cholesterol by the combination of the two methodsP Samuel, Dr0S Lieberman1E H Ahrens, Jr2The Rockefeller University, New York, NY 10021; Department of Mathematics, Queens College of the City University of New York, Flushing, NY 11367; The Rockefeller University, New York, N.Y. 10021; Address reprint requests to: Dr. Paul SamuelThe Rockefeller University, New York, NY 10021; Department of Mathematics, Queens College of the City University of New York, Flushing, NY 11367The Rockefeller University, New York, NY 10021; Department of Mathematics, Queens College of the City University of New York, Flushing, NY 11367Daily turnover of cholesterol obtained by the balance method was compared to daily input rates calculated by input–output analysis in 43 experiments. The mean value of input rates for kinetic data of 10.1–16.4 weeks' duration (14 experiments) was 1.05 g/day vs. the chemical turnover of 0.94 g/day (difference 10.9%). For decay curves of 4.8–9.9 weeks' duration (29 experiments) the mean results were 1.67 g/day vs. 1.31 g/day, respectively (difference 20.1%). A combination of the balance method with input-output analysis is proposed to estimate the size of M (minimum value of the total exchangeable mass of cholesterol) in short-term experiments. Using this method, the analysis of curves of 10–12 weeks' duration showed a mean difference of 7.5% with the analysis of curves of 50–66 weeks' duration in 17 patients. However, because of considerable variations that can occur in individual cases, it is urged that a standard correction factor not be used, either in estimating turnover data or M from 10–12 weeks' kinetic data; rather, the proposed combined method will alert the investigator to the occurrence of discrepant results.http://www.sciencedirect.com/science/article/pii/S0022227520415809intravenous tracercomputer analysishyperlipidemiaatherosclerosiscoronary artery disease |
| spellingShingle | P Samuel, Dr S Lieberman E H Ahrens, Jr Comparison of cholesterol turnover by sterol balance and input–output analysis, and a shortened way to estimate total exchangeable mass of cholesterol by the combination of the two methods Journal of Lipid Research intravenous tracer computer analysis hyperlipidemia atherosclerosis coronary artery disease |
| title | Comparison of cholesterol turnover by sterol balance and input–output analysis, and a shortened way to estimate total exchangeable mass of cholesterol by the combination of the two methods |
| title_full | Comparison of cholesterol turnover by sterol balance and input–output analysis, and a shortened way to estimate total exchangeable mass of cholesterol by the combination of the two methods |
| title_fullStr | Comparison of cholesterol turnover by sterol balance and input–output analysis, and a shortened way to estimate total exchangeable mass of cholesterol by the combination of the two methods |
| title_full_unstemmed | Comparison of cholesterol turnover by sterol balance and input–output analysis, and a shortened way to estimate total exchangeable mass of cholesterol by the combination of the two methods |
| title_short | Comparison of cholesterol turnover by sterol balance and input–output analysis, and a shortened way to estimate total exchangeable mass of cholesterol by the combination of the two methods |
| title_sort | comparison of cholesterol turnover by sterol balance and input output analysis and a shortened way to estimate total exchangeable mass of cholesterol by the combination of the two methods |
| topic | intravenous tracer computer analysis hyperlipidemia atherosclerosis coronary artery disease |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520415809 |
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