Salidroside mediated stabilization of Bcl -xL prevents mitophagy in CA3 hippocampal neurons during hypoxia

Salidroside mediated stabilization of Bcl -xL prevents mitophagy in CA3 hippocampal neurons during hypoxia

Chronic hypoxic stress results in deposition of lipofuscin granules in the CA3 region of hippocampal neurons which contributes to neurodegeneration and accelerated neuronal aging. Oxidative stress and mitophagy during hypoxia are crucial to cause aggregation of these lipofuscin granules in hypoxic n...

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Bibliographic Details
Main Authors: Suryanarayan Biswal, Kalpana Kumari Barhwal, Debashree Das, Richa Dhingra, Nilima Dhingra, Tapas Chanda Nag, Sunil Kumar Hota
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Neurobiology of Disease
Subjects:
Hypoxia
Lipofuscin
Mitophagy
Bcl-xL
FUNDC1
Salidroside
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118301359

Internet

http://www.sciencedirect.com/science/article/pii/S0969996118301359

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