Association between SNPs in microRNAs and microRNAs-Machinery Genes with Susceptibility of Leprosy in the Amazon Population
Leprosy is a chronic neurodermatological disease caused by the bacillus <i>Mycobacterium leprae</i>. Recent studies show that SNPs in genes related to miRNAs have been associated with several diseases in different populations. This study aimed to evaluate the association of twenty-five S...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/18/10628 |
| Summary: | Leprosy is a chronic neurodermatological disease caused by the bacillus <i>Mycobacterium leprae</i>. Recent studies show that SNPs in genes related to miRNAs have been associated with several diseases in different populations. This study aimed to evaluate the association of twenty-five SNPs in genes encoding miRNAs related to biological processes and immune response with susceptibility to leprosy and its polar forms paucibacillary and multibacillary in the Brazilian Amazon. A total of 114 leprosy patients and 71 household contacts were included in this study. Genotyping was performed using TaqMan Open Array Genotyping. Ancestry-informative markers were used to estimate individual proportions of case and control groups. The SNP rs2505901 (<i>pre-miR938</i>) was associated with protection against the development of paucibacillary leprosy, while the SNPs rs639174 (<i>DROSHA</i>), rs636832 (<i>AGO1</i>), and rs4143815 (<i>miR570</i>) were associated with protection against the development of multibacillary leprosy. In contrast, the SNPs rs10739971 (<i>pri-let-7a1</i>), rs12904 (<i>miR200C</i>), and rs2168518 (<i>miR4513</i>) are associated with the development of the paucibacillary leprosy. The rs10739971 (<i>pri-let-7a1</i>) polymorphism was associated with the development of leprosy, while rs2910164 (<i>miR146A</i>) and rs10035440 (<i>DROSHA</i>) was significantly associated with an increased risk of developing multibacillary leprosy. |
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| ISSN: | 1661-6596 1422-0067 |