Host obesity alters the ovarian tumor immune microenvironment and impacts response to standard of care chemotherapy

Host obesity alters the ovarian tumor immune microenvironment and impacts response to standard of care chemotherapy

Abstract Background The majority of women with epithelial ovarian cancer (OvCa) are diagnosed with metastatic disease, resulting in a poor 5-year survival of 31%. Obesity is a recognized non-infectious pandemic that increases OvCa incidence, enhances metastatic success and reduces survival. We have...

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Bibliographic Details
Main Authors: Yueying Liu, Jing Yang, Tyvette S. Hilliard, Zhikun Wang, Jeff Johnson, Wanrui Wang, Elizabeth I. Harper, Connor Ott, Caitlin O’Brien, Leigh Campbell, Brian Crowley, Stephen Grisoli, Nicholas M. Stavrou, Anna Juncker-Jensen, M. Sharon Stack
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ovarian cancer
Obesity
High fat diet
Tumor-associated macrophage
Fibrosis
Online Access:https://doi.org/10.1186/s13046-023-02740-y

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