Characteristics of CD8+ T cell subsets in Chinese patients with chronic HIV infection during initial ART
<p>Abstract</p> <p>Background</p> <p>CD8+ T cells may play an important role in protecting against HIV. However, the changes of CD8+ T cell subsets during early period of ART have not been fully studied.</p> <p>Methods</p> <p>Twenty-one asymptoma...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-03-01
|
| Series: | AIDS Research and Therapy |
| Online Access: | http://www.aidsrestherapy.com/content/8/1/15 |
| _version_ | 1818963800483692544 |
|---|---|
| author | Zhang Hongwei Ji Yunxia Zhang Yonghong Zhang Tong Hua Wei Jiao Yanmei Wu Hao |
| author_facet | Zhang Hongwei Ji Yunxia Zhang Yonghong Zhang Tong Hua Wei Jiao Yanmei Wu Hao |
| author_sort | Zhang Hongwei |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>CD8+ T cells may play an important role in protecting against HIV. However, the changes of CD8+ T cell subsets during early period of ART have not been fully studied.</p> <p>Methods</p> <p>Twenty-one asymptomatic treatment-naive HIV-infected patients with CD4 T+ cells less than 350 cells/μl were enrolled in the study. Naïve, central memory(CM), effective memory(EM) and terminally differentiated effector (EMRA) CD8+ cell subsets and their activation and proliferation subsets were evaluated in blood samples collected at base line, and week 2, 4, 8 and 12 of ART.</p> <p>Results</p> <p>The total CD8+ T cells declined and the Naïve and CM subsets had a tendency of increase. Activation levels of all CD8+ T cell subsets except EMRA subset decreased after ART. However, proliferation levels of total CD8+ T cells, EMRA, EM and CM subsets increased at the first 4 weeks of ART, then decreased. Proliferation level of the naïve cells decreased after ART.</p> <p>Conclusion</p> <p>The changes of CD8+ T cell subsets during initial ART are complex. Our results display a complete phenotypical picture of CD8+ cell subsets during initial ART and provide insights for understanding of immune status during ART.</p> |
| first_indexed | 2024-12-20T12:50:58Z |
| format | Article |
| id | doaj.art-5c92334b8c0a4fb48ef174c5e59d1666 |
| institution | Directory Open Access Journal |
| issn | 1742-6405 |
| language | English |
| last_indexed | 2024-12-20T12:50:58Z |
| publishDate | 2011-03-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj.art-5c92334b8c0a4fb48ef174c5e59d16662022-12-21T19:40:11ZengBMCAIDS Research and Therapy1742-64052011-03-01811510.1186/1742-6405-8-15Characteristics of CD8+ T cell subsets in Chinese patients with chronic HIV infection during initial ARTZhang HongweiJi YunxiaZhang YonghongZhang TongHua WeiJiao YanmeiWu Hao<p>Abstract</p> <p>Background</p> <p>CD8+ T cells may play an important role in protecting against HIV. However, the changes of CD8+ T cell subsets during early period of ART have not been fully studied.</p> <p>Methods</p> <p>Twenty-one asymptomatic treatment-naive HIV-infected patients with CD4 T+ cells less than 350 cells/μl were enrolled in the study. Naïve, central memory(CM), effective memory(EM) and terminally differentiated effector (EMRA) CD8+ cell subsets and their activation and proliferation subsets were evaluated in blood samples collected at base line, and week 2, 4, 8 and 12 of ART.</p> <p>Results</p> <p>The total CD8+ T cells declined and the Naïve and CM subsets had a tendency of increase. Activation levels of all CD8+ T cell subsets except EMRA subset decreased after ART. However, proliferation levels of total CD8+ T cells, EMRA, EM and CM subsets increased at the first 4 weeks of ART, then decreased. Proliferation level of the naïve cells decreased after ART.</p> <p>Conclusion</p> <p>The changes of CD8+ T cell subsets during initial ART are complex. Our results display a complete phenotypical picture of CD8+ cell subsets during initial ART and provide insights for understanding of immune status during ART.</p>http://www.aidsrestherapy.com/content/8/1/15 |
| spellingShingle | Zhang Hongwei Ji Yunxia Zhang Yonghong Zhang Tong Hua Wei Jiao Yanmei Wu Hao Characteristics of CD8+ T cell subsets in Chinese patients with chronic HIV infection during initial ART AIDS Research and Therapy |
| title | Characteristics of CD8+ T cell subsets in Chinese patients with chronic HIV infection during initial ART |
| title_full | Characteristics of CD8+ T cell subsets in Chinese patients with chronic HIV infection during initial ART |
| title_fullStr | Characteristics of CD8+ T cell subsets in Chinese patients with chronic HIV infection during initial ART |
| title_full_unstemmed | Characteristics of CD8+ T cell subsets in Chinese patients with chronic HIV infection during initial ART |
| title_short | Characteristics of CD8+ T cell subsets in Chinese patients with chronic HIV infection during initial ART |
| title_sort | characteristics of cd8 t cell subsets in chinese patients with chronic hiv infection during initial art |
| url | http://www.aidsrestherapy.com/content/8/1/15 |
| work_keys_str_mv | AT zhanghongwei characteristicsofcd8tcellsubsetsinchinesepatientswithchronichivinfectionduringinitialart AT jiyunxia characteristicsofcd8tcellsubsetsinchinesepatientswithchronichivinfectionduringinitialart AT zhangyonghong characteristicsofcd8tcellsubsetsinchinesepatientswithchronichivinfectionduringinitialart AT zhangtong characteristicsofcd8tcellsubsetsinchinesepatientswithchronichivinfectionduringinitialart AT huawei characteristicsofcd8tcellsubsetsinchinesepatientswithchronichivinfectionduringinitialart AT jiaoyanmei characteristicsofcd8tcellsubsetsinchinesepatientswithchronichivinfectionduringinitialart AT wuhao characteristicsofcd8tcellsubsetsinchinesepatientswithchronichivinfectionduringinitialart |