Early Antibody-Mediated Kidney Transplant Rejection: A Successful Case Without Donor-Specific Anti-HLA Antibodies
The diagnosis of antibody-mediated rejection has become more common and represents a major cause of kidney graft loss. The ideal treatment remains unknown, with little evidence supporting the use of a specific therapy. The definition of antibody-mediated rejection is based on serologic (presence a...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Publicações Ciência e Vida
2023-06-01
|
| Series: | Revista Portuguesa de Nefrologia e Hipertensão |
| Subjects: | |
| Online Access: | https://spnefro.pt/_doi/reference/6ede97e2-2ef1-4a16-acbd-caa7a2ecbcb2 |
| Summary: | The diagnosis of antibody-mediated rejection has become more common and represents a major cause of kidney graft loss. The ideal
treatment remains unknown, with little evidence supporting the use of a specific therapy. The definition of antibody-mediated rejection is
based on serologic (presence and/or development of donor-specific antibodies) and histologic (evidence of acute tissue injury with C4d deposition or other signs of antibody interaction with the vascular endothelium) criteria. Antibody-mediated rejection without donor-specific antibodies is a subcategory with a defying diagnosis. This particularly entity is increasingly being reported as an important cause of allograft
dysfunction in kidney transplantation. We describe the case of a kidney transplant recipient with a low immunological risk and delayed graft
function due to an antibody-mediated rejection with negative donor-specific antibodies. |
|---|---|
| ISSN: | 0872-0169 2183-1289 |