Early Antibody-Mediated Kidney Transplant Rejection: A Successful Case Without Donor-Specific Anti-HLA Antibodies
The diagnosis of antibody-mediated rejection has become more common and represents a major cause of kidney graft loss. The ideal treatment remains unknown, with little evidence supporting the use of a specific therapy. The definition of antibody-mediated rejection is based on serologic (presence a...
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| Format: | Article |
| Language: | English |
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Publicações Ciência e Vida
2023-06-01
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| Series: | Revista Portuguesa de Nefrologia e Hipertensão |
| Subjects: | |
| Online Access: | https://spnefro.pt/_doi/reference/6ede97e2-2ef1-4a16-acbd-caa7a2ecbcb2 |
| _version_ | 1797767262605672448 |
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| author | Rita M. Silva Rita Leal Maria G. Marques Luís Rodrigues Lídia Santos Catarina Romãozinho Arnaldo Figueiredo Rui Alves |
| author_facet | Rita M. Silva Rita Leal Maria G. Marques Luís Rodrigues Lídia Santos Catarina Romãozinho Arnaldo Figueiredo Rui Alves |
| author_sort | Rita M. Silva |
| collection | DOAJ |
| description | The diagnosis of antibody-mediated rejection has become more common and represents a major cause of kidney graft loss. The ideal
treatment remains unknown, with little evidence supporting the use of a specific therapy. The definition of antibody-mediated rejection is
based on serologic (presence and/or development of donor-specific antibodies) and histologic (evidence of acute tissue injury with C4d deposition or other signs of antibody interaction with the vascular endothelium) criteria. Antibody-mediated rejection without donor-specific antibodies is a subcategory with a defying diagnosis. This particularly entity is increasingly being reported as an important cause of allograft
dysfunction in kidney transplantation. We describe the case of a kidney transplant recipient with a low immunological risk and delayed graft
function due to an antibody-mediated rejection with negative donor-specific antibodies. |
| first_indexed | 2024-03-12T20:37:10Z |
| format | Article |
| id | doaj.art-5c92b032b4a74586b3d779e94aa658ca |
| institution | Directory Open Access Journal |
| issn | 0872-0169 2183-1289 |
| language | English |
| last_indexed | 2024-03-12T20:37:10Z |
| publishDate | 2023-06-01 |
| publisher | Publicações Ciência e Vida |
| record_format | Article |
| series | Revista Portuguesa de Nefrologia e Hipertensão |
| spelling | doaj.art-5c92b032b4a74586b3d779e94aa658ca2023-08-01T12:52:14ZengPublicações Ciência e VidaRevista Portuguesa de Nefrologia e Hipertensão0872-01692183-12892023-06-01372899210.32932/pjnh.2023.05.239Early Antibody-Mediated Kidney Transplant Rejection: A Successful Case Without Donor-Specific Anti-HLA AntibodiesRita M. Silva0https://orcid.org/0000-0002-0869-1251Rita Leal1https://orcid.org/0000-0003-0614-3902Maria G. Marques2https://orcid.org/0000-0002-3210-3050Luís Rodrigues3https://orcid.org/0000-0003-0122-982XLídia Santos4Catarina Romãozinho5https://orcid.org/0000-0002-5526-9336Arnaldo Figueiredo6https://orcid.org/0000-0002-7157-0081Rui Alves7https://orcid.org/0000-0003-3922-3618Department of Nephrology, Urology, and Kidney Transplantation, Coimbra University Hospital Center, Coimbra, PortugalDepartment of Nephrology, Urology, and Kidney Transplantation, Coimbra University Hospital Center, Coimbra, Portugal; Nephrology University Clinic, Faculty of Medicine, University of Coimbra, Coimbra, PortugalDepartment of Nephrology, Urology, and Kidney Transplantation, Coimbra University Hospital Center, Coimbra, Portugal; Nephrology University Clinic, Faculty of Medicine, University of Coimbra, Coimbra, PortugalDepartment of Nephrology, Urology, and Kidney Transplantation, Coimbra University Hospital Center, Coimbra, Portugal; Nephrology University Clinic, Faculty of Medicine, University of Coimbra, Coimbra, PortugalDepartment of Nephrology, Urology, and Kidney Transplantation, Coimbra University Hospital Center, Coimbra, Portugal; Nephrology University Clinic, Faculty of Medicine, University of Coimbra, Coimbra, PortugalDepartment of Nephrology, Urology, and Kidney Transplantation, Coimbra University Hospital Center, Coimbra, Portugal; Nephrology University Clinic, Faculty of Medicine, University of Coimbra, Coimbra, PortugalDepartment of Nephrology, Urology, and Kidney Transplantation, Coimbra University Hospital Center, Coimbra, Portugal; Urology University Clinic, Faculty of Medicine, University of Coimbra, Coimbra, PortugalDepartment of Nephrology, Urology, and Kidney Transplantation, Coimbra University Hospital Center, Coimbra, Portugal; Nephrology University Clinic, Faculty of Medicine, University of Coimbra, Coimbra, PortugalThe diagnosis of antibody-mediated rejection has become more common and represents a major cause of kidney graft loss. The ideal treatment remains unknown, with little evidence supporting the use of a specific therapy. The definition of antibody-mediated rejection is based on serologic (presence and/or development of donor-specific antibodies) and histologic (evidence of acute tissue injury with C4d deposition or other signs of antibody interaction with the vascular endothelium) criteria. Antibody-mediated rejection without donor-specific antibodies is a subcategory with a defying diagnosis. This particularly entity is increasingly being reported as an important cause of allograft dysfunction in kidney transplantation. We describe the case of a kidney transplant recipient with a low immunological risk and delayed graft function due to an antibody-mediated rejection with negative donor-specific antibodies. https://spnefro.pt/_doi/reference/6ede97e2-2ef1-4a16-acbd-caa7a2ecbcb2graft rejection/immunologyhistocompatibility/immunologyhla antigens/immunologyisoantibodies/immunologykidney transplantation |
| spellingShingle | Rita M. Silva Rita Leal Maria G. Marques Luís Rodrigues Lídia Santos Catarina Romãozinho Arnaldo Figueiredo Rui Alves Early Antibody-Mediated Kidney Transplant Rejection: A Successful Case Without Donor-Specific Anti-HLA Antibodies Revista Portuguesa de Nefrologia e Hipertensão graft rejection/immunology histocompatibility/immunology hla antigens/immunology isoantibodies/immunology kidney transplantation |
| title | Early Antibody-Mediated Kidney Transplant Rejection: A Successful Case Without Donor-Specific Anti-HLA Antibodies |
| title_full | Early Antibody-Mediated Kidney Transplant Rejection: A Successful Case Without Donor-Specific Anti-HLA Antibodies |
| title_fullStr | Early Antibody-Mediated Kidney Transplant Rejection: A Successful Case Without Donor-Specific Anti-HLA Antibodies |
| title_full_unstemmed | Early Antibody-Mediated Kidney Transplant Rejection: A Successful Case Without Donor-Specific Anti-HLA Antibodies |
| title_short | Early Antibody-Mediated Kidney Transplant Rejection: A Successful Case Without Donor-Specific Anti-HLA Antibodies |
| title_sort | early antibody mediated kidney transplant rejection a successful case without donor specific anti hla antibodies |
| topic | graft rejection/immunology histocompatibility/immunology hla antigens/immunology isoantibodies/immunology kidney transplantation |
| url | https://spnefro.pt/_doi/reference/6ede97e2-2ef1-4a16-acbd-caa7a2ecbcb2 |
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