Alcool e radicais livres de oxigénio.
Oxygen free radicals may be generated during ethanol metabolization by cytochrome P450, or due to the formation of xanthine oxidase by ethanol effect on xanthine dehydrogenase. After transformation into acetaldehyde, the metabolism of this compound by xanthine oxidase or by aldehyde oxidase also gen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Ordem dos Médicos
1993-05-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3075 |
| _version_ | 1811242504445493248 |
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| author | M L Mira C F Manso |
| author_facet | M L Mira C F Manso |
| author_sort | M L Mira |
| collection | DOAJ |
| description | Oxygen free radicals may be generated during ethanol metabolization by cytochrome P450, or due to the formation of xanthine oxidase by ethanol effect on xanthine dehydrogenase. After transformation into acetaldehyde, the metabolism of this compound by xanthine oxidase or by aldehyde oxidase also generates oxygen radicals. We present the hypothesis of a vicious cycle during ethanol metabolization by aldehyde oxidase, which would amplify the process and be responsible for an increased degree of lipid peroxidation. |
| first_indexed | 2024-04-12T13:52:08Z |
| format | Article |
| id | doaj.art-5c9322a6396c468082dd531a1a21a938 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-12T13:52:08Z |
| publishDate | 1993-05-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-5c9322a6396c468082dd531a1a21a9382022-12-22T03:30:29ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07581993-05-016510.20344/amp.3075Alcool e radicais livres de oxigénio.M L Mira0C F MansoInstituto de Química Fisiológica, Faculdade de Medicina, Lisboa.Oxygen free radicals may be generated during ethanol metabolization by cytochrome P450, or due to the formation of xanthine oxidase by ethanol effect on xanthine dehydrogenase. After transformation into acetaldehyde, the metabolism of this compound by xanthine oxidase or by aldehyde oxidase also generates oxygen radicals. We present the hypothesis of a vicious cycle during ethanol metabolization by aldehyde oxidase, which would amplify the process and be responsible for an increased degree of lipid peroxidation.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3075 |
| spellingShingle | M L Mira C F Manso Alcool e radicais livres de oxigénio. Acta Médica Portuguesa |
| title | Alcool e radicais livres de oxigénio. |
| title_full | Alcool e radicais livres de oxigénio. |
| title_fullStr | Alcool e radicais livres de oxigénio. |
| title_full_unstemmed | Alcool e radicais livres de oxigénio. |
| title_short | Alcool e radicais livres de oxigénio. |
| title_sort | alcool e radicais livres de oxigenio |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3075 |
| work_keys_str_mv | AT mlmira alcooleradicaislivresdeoxigenio AT cfmanso alcooleradicaislivresdeoxigenio |