Marine-Inspired Approaches as a Smart Tool to Face Osteochondral Regeneration
The degeneration of osteochondral tissue represents one of the major causes of disability in modern society and it is expected to fuel the demand for new solutions to repair and regenerate the damaged articular joints. In particular, osteoarthritis (OA) is the most common complication in articular d...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/21/4/212 |
| _version_ | 1797604600062148608 |
|---|---|
| author | Anna Tampieri Elizaveta Kon Monica Sandri Elisabetta Campodoni Massimiliano Dapporto Simone Sprio |
| author_facet | Anna Tampieri Elizaveta Kon Monica Sandri Elisabetta Campodoni Massimiliano Dapporto Simone Sprio |
| author_sort | Anna Tampieri |
| collection | DOAJ |
| description | The degeneration of osteochondral tissue represents one of the major causes of disability in modern society and it is expected to fuel the demand for new solutions to repair and regenerate the damaged articular joints. In particular, osteoarthritis (OA) is the most common complication in articular diseases and a leading cause of chronic disability affecting a steady increasing number of people. The regeneration of osteochondral (OC) defects is one of the most challenging tasks in orthopedics since this anatomical region is composed of different tissues, characterized by antithetic features and functionalities, in tight connection to work together as a joint. The altered structural and mechanical joint environment impairs the natural tissue metabolism, thus making OC regeneration even more challenging. In this scenario, marine-derived ingredients elicit ever-increased interest for biomedical applications as a result of their outstanding mechanical and multiple biologic properties. The review highlights the possibility to exploit such unique features using a combination of bio-inspired synthesis process and 3D manufacturing technologies, relevant to generate compositionally and structurally graded hybrid constructs reproducing the smart architecture and biomechanical functions of natural OC regions. |
| first_indexed | 2024-03-11T04:48:34Z |
| format | Article |
| id | doaj.art-5c95981741af4760bf84b94e3ec7c281 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-11T04:48:34Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-5c95981741af4760bf84b94e3ec7c2812023-11-17T20:10:02ZengMDPI AGMarine Drugs1660-33972023-03-0121421210.3390/md21040212Marine-Inspired Approaches as a Smart Tool to Face Osteochondral RegenerationAnna Tampieri0Elizaveta Kon1Monica Sandri2Elisabetta Campodoni3Massimiliano Dapporto4Simone Sprio5Institute of Science, Technology and Sustainability for Ceramics, ISSMC-CNR (Former ISTEC-CNR), 40129 Faenza, ItalyHumanitas Research Hospital, 20089 Rozzano, ItalyInstitute of Science, Technology and Sustainability for Ceramics, ISSMC-CNR (Former ISTEC-CNR), 40129 Faenza, ItalyInstitute of Science, Technology and Sustainability for Ceramics, ISSMC-CNR (Former ISTEC-CNR), 40129 Faenza, ItalyInstitute of Science, Technology and Sustainability for Ceramics, ISSMC-CNR (Former ISTEC-CNR), 40129 Faenza, ItalyInstitute of Science, Technology and Sustainability for Ceramics, ISSMC-CNR (Former ISTEC-CNR), 40129 Faenza, ItalyThe degeneration of osteochondral tissue represents one of the major causes of disability in modern society and it is expected to fuel the demand for new solutions to repair and regenerate the damaged articular joints. In particular, osteoarthritis (OA) is the most common complication in articular diseases and a leading cause of chronic disability affecting a steady increasing number of people. The regeneration of osteochondral (OC) defects is one of the most challenging tasks in orthopedics since this anatomical region is composed of different tissues, characterized by antithetic features and functionalities, in tight connection to work together as a joint. The altered structural and mechanical joint environment impairs the natural tissue metabolism, thus making OC regeneration even more challenging. In this scenario, marine-derived ingredients elicit ever-increased interest for biomedical applications as a result of their outstanding mechanical and multiple biologic properties. The review highlights the possibility to exploit such unique features using a combination of bio-inspired synthesis process and 3D manufacturing technologies, relevant to generate compositionally and structurally graded hybrid constructs reproducing the smart architecture and biomechanical functions of natural OC regions.https://www.mdpi.com/1660-3397/21/4/212osteochondral scaffoldhybrid materialsmarine-derived ingredientsfucoidansmutable collagenapatites |
| spellingShingle | Anna Tampieri Elizaveta Kon Monica Sandri Elisabetta Campodoni Massimiliano Dapporto Simone Sprio Marine-Inspired Approaches as a Smart Tool to Face Osteochondral Regeneration Marine Drugs osteochondral scaffold hybrid materials marine-derived ingredients fucoidans mutable collagen apatites |
| title | Marine-Inspired Approaches as a Smart Tool to Face Osteochondral Regeneration |
| title_full | Marine-Inspired Approaches as a Smart Tool to Face Osteochondral Regeneration |
| title_fullStr | Marine-Inspired Approaches as a Smart Tool to Face Osteochondral Regeneration |
| title_full_unstemmed | Marine-Inspired Approaches as a Smart Tool to Face Osteochondral Regeneration |
| title_short | Marine-Inspired Approaches as a Smart Tool to Face Osteochondral Regeneration |
| title_sort | marine inspired approaches as a smart tool to face osteochondral regeneration |
| topic | osteochondral scaffold hybrid materials marine-derived ingredients fucoidans mutable collagen apatites |
| url | https://www.mdpi.com/1660-3397/21/4/212 |
| work_keys_str_mv | AT annatampieri marineinspiredapproachesasasmarttooltofaceosteochondralregeneration AT elizavetakon marineinspiredapproachesasasmarttooltofaceosteochondralregeneration AT monicasandri marineinspiredapproachesasasmarttooltofaceosteochondralregeneration AT elisabettacampodoni marineinspiredapproachesasasmarttooltofaceosteochondralregeneration AT massimilianodapporto marineinspiredapproachesasasmarttooltofaceosteochondralregeneration AT simonesprio marineinspiredapproachesasasmarttooltofaceosteochondralregeneration |