Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma
ABSTRACTAlternative splicing is a process causing mRNA translation to produce different proteins, and it is crucial for the development of tumours. In this study, we constructed a prognostic model related to alternative splicing events in hepatocarcinoma using bioinformatics analysis, including the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15592294.2023.2276371 |
| _version_ | 1797635967844089856 |
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| author | Zhenyi Lv Wenqi Gao Zhiwei Du Yi Zheng Tianming Liu Chenjun Hao Dongbo Xue |
| author_facet | Zhenyi Lv Wenqi Gao Zhiwei Du Yi Zheng Tianming Liu Chenjun Hao Dongbo Xue |
| author_sort | Zhenyi Lv |
| collection | DOAJ |
| description | ABSTRACTAlternative splicing is a process causing mRNA translation to produce different proteins, and it is crucial for the development of tumours. In this study, we constructed a prognostic model related to alternative splicing events in hepatocarcinoma using bioinformatics analysis, including the alternative splicing of CSAD, AFMID, ZDHHC16, and IRF3. The model is an independent prognostic factor and can accurately predict a patient’s prognosis. IRF3 is a transcription factor related to the immune response. Its alternative splicing can affect the expression of various genes related to prognosis and plays an essential role in the tumour microenvironment. We also verified the expression of IRF3 exon skipping isoform in hepatocarcinoma at the mRNA level. In conclusion, we discovered that the alternative splicing of IRF3 is essential for the development of hepatocarcinoma. This study provides new insight into the development of treatments for hepatocarcinoma. |
| first_indexed | 2024-03-11T12:28:06Z |
| format | Article |
| id | doaj.art-5c99ede2c10841dca7a5a164daf4e0cc |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-11T12:28:06Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-5c99ede2c10841dca7a5a164daf4e0cc2023-11-06T05:37:16ZengTaylor & Francis GroupEpigenetics1559-22941559-23082023-12-0118110.1080/15592294.2023.2276371Alternative splicing of IRF3 plays an important role in the development of hepatocarcinomaZhenyi Lv0Wenqi Gao1Zhiwei Du2Yi Zheng3Tianming Liu4Chenjun Hao5Dongbo Xue6Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, ChinaKey Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, ChinaKey Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, ChinaKey Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, ChinaKey Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, ChinaKey Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, ChinaKey Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, ChinaABSTRACTAlternative splicing is a process causing mRNA translation to produce different proteins, and it is crucial for the development of tumours. In this study, we constructed a prognostic model related to alternative splicing events in hepatocarcinoma using bioinformatics analysis, including the alternative splicing of CSAD, AFMID, ZDHHC16, and IRF3. The model is an independent prognostic factor and can accurately predict a patient’s prognosis. IRF3 is a transcription factor related to the immune response. Its alternative splicing can affect the expression of various genes related to prognosis and plays an essential role in the tumour microenvironment. We also verified the expression of IRF3 exon skipping isoform in hepatocarcinoma at the mRNA level. In conclusion, we discovered that the alternative splicing of IRF3 is essential for the development of hepatocarcinoma. This study provides new insight into the development of treatments for hepatocarcinoma.https://www.tandfonline.com/doi/10.1080/15592294.2023.2276371Alternative splicingexon skiphepatocellular carcinomaIRF3immune infiltration |
| spellingShingle | Zhenyi Lv Wenqi Gao Zhiwei Du Yi Zheng Tianming Liu Chenjun Hao Dongbo Xue Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma Epigenetics Alternative splicing exon skip hepatocellular carcinoma IRF3 immune infiltration |
| title | Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma |
| title_full | Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma |
| title_fullStr | Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma |
| title_full_unstemmed | Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma |
| title_short | Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma |
| title_sort | alternative splicing of irf3 plays an important role in the development of hepatocarcinoma |
| topic | Alternative splicing exon skip hepatocellular carcinoma IRF3 immune infiltration |
| url | https://www.tandfonline.com/doi/10.1080/15592294.2023.2276371 |
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