Non-invasive electromagnetic detection of prostate cancer: efficiency analysis
Introduction. Early diagnosis of cancer is one of the most important international strategies. Malignant and healthy tissues differ in the interaction with electromagnetic waves. Pilot studies show a potential perspective for non-invasive analysis of electromagnetic anisotropy in biological tissues....
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2023-04-01
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| Series: | Vestnik Urologii |
| Subjects: | |
| Online Access: | https://www.urovest.ru/jour/article/view/675 |
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| author | M. E. Chaliy E. V. Afanasyevskaya A. S. Amirkhanyan A. A. Strigunov A. M. Kadysheva E. V. Kolygina A. S. Shurygina A. S. Tivtikyan A. V. Kadrev V. K. Dzitiev D. A. Okhobotov N. I. Sorokin A. A. Kamalov |
| author_facet | M. E. Chaliy E. V. Afanasyevskaya A. S. Amirkhanyan A. A. Strigunov A. M. Kadysheva E. V. Kolygina A. S. Shurygina A. S. Tivtikyan A. V. Kadrev V. K. Dzitiev D. A. Okhobotov N. I. Sorokin A. A. Kamalov |
| author_sort | M. E. Chaliy |
| collection | DOAJ |
| description | Introduction. Early diagnosis of cancer is one of the most important international strategies. Malignant and healthy tissues differ in the interaction with electromagnetic waves. Pilot studies show a potential perspective for non-invasive analysis of electromagnetic anisotropy in biological tissues.Objective. To assess the diagnostic importance of the electromagnetic detection of prostate cancer (PCa) within the prospective study.Materials & methods. One hundred and twenty-four patients were included to undergo a prostate biopsy, transurethral prostate resection, or radical prostatectomy. The investigators did not have information on their clinical details. Research technique: the probe was applied to the perineal region, turning it in three planes. A reduction of the 465 MHz band below a threshold was fixed and was considered suspect for PCa. The results of electromagnetic evaluation were compared with the findings of a pathomorphological study after biopsy or surgery.Results. Fourty-seven true-positive and 21 true-negative results were detected, 20 false-negative and 46 false-positive (follow-up group as potentially true-positive group). The overall sensitivity was 82%, specificity – 31%. The positive and negative predictive values were 73% and 62%, respectively. The accuracy of the method was 54%.Conclusion. Early PCa stage could be a reason for many false-positive results and low specificity, as a result. PCa detection is significantly reduced with lesions less than 3 mm, therefore patients with false-positive results were placed in the follow-up group. Patients’ examination with the TRIMprob TM («Galileo Avionica» SpA, Torino, Italy) could increase the early PCa detection at the screening. The research is currently ongoing. |
| first_indexed | 2024-03-07T14:23:12Z |
| format | Article |
| id | doaj.art-5c9a64a29b5e45f5800b4cc067017c25 |
| institution | Directory Open Access Journal |
| issn | 2308-6424 |
| language | Russian |
| last_indexed | 2024-03-07T14:23:12Z |
| publishDate | 2023-04-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Vestnik Urologii |
| spelling | doaj.art-5c9a64a29b5e45f5800b4cc067017c252024-03-06T08:56:06ZrusState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationVestnik Urologii2308-64242023-04-0111110811510.21886/2308-6424-2023-11-1-108-115426Non-invasive electromagnetic detection of prostate cancer: efficiency analysisM. E. Chaliy0E. V. Afanasyevskaya1A. S. Amirkhanyan2A. A. Strigunov3A. M. Kadysheva4E. V. Kolygina5A. S. Shurygina6A. S. Tivtikyan7A. V. Kadrev8V. K. Dzitiev9D. A. Okhobotov10N. I. Sorokin11A. A. Kamalov12Lomonosov Moscow State University (Lomonosov University)Lomonosov Moscow State University (Lomonosov University); Istra Regional Clinical HospitalLomonosov Moscow State University (Lomonosov University); Istra Regional Clinical HospitalLomonosov Moscow State University (Lomonosov University)Lomonosov Moscow State University (Lomonosov University)Lomonosov Moscow State University (Lomonosov University)Lomonosov Moscow State University (Lomonosov University)Lomonosov Moscow State University (Lomonosov University)Lomonosov Moscow State University (Lomonosov University)Lomonosov Moscow State University (Lomonosov University)Lomonosov Moscow State University (Lomonosov University)Lomonosov Moscow State University (Lomonosov University)Lomonosov Moscow State University (Lomonosov University)Introduction. Early diagnosis of cancer is one of the most important international strategies. Malignant and healthy tissues differ in the interaction with electromagnetic waves. Pilot studies show a potential perspective for non-invasive analysis of electromagnetic anisotropy in biological tissues.Objective. To assess the diagnostic importance of the electromagnetic detection of prostate cancer (PCa) within the prospective study.Materials & methods. One hundred and twenty-four patients were included to undergo a prostate biopsy, transurethral prostate resection, or radical prostatectomy. The investigators did not have information on their clinical details. Research technique: the probe was applied to the perineal region, turning it in three planes. A reduction of the 465 MHz band below a threshold was fixed and was considered suspect for PCa. The results of electromagnetic evaluation were compared with the findings of a pathomorphological study after biopsy or surgery.Results. Fourty-seven true-positive and 21 true-negative results were detected, 20 false-negative and 46 false-positive (follow-up group as potentially true-positive group). The overall sensitivity was 82%, specificity – 31%. The positive and negative predictive values were 73% and 62%, respectively. The accuracy of the method was 54%.Conclusion. Early PCa stage could be a reason for many false-positive results and low specificity, as a result. PCa detection is significantly reduced with lesions less than 3 mm, therefore patients with false-positive results were placed in the follow-up group. Patients’ examination with the TRIMprob TM («Galileo Avionica» SpA, Torino, Italy) could increase the early PCa detection at the screening. The research is currently ongoing.https://www.urovest.ru/jour/article/view/675prostate cancertissue resonance interactionprostate-specific antigen |
| spellingShingle | M. E. Chaliy E. V. Afanasyevskaya A. S. Amirkhanyan A. A. Strigunov A. M. Kadysheva E. V. Kolygina A. S. Shurygina A. S. Tivtikyan A. V. Kadrev V. K. Dzitiev D. A. Okhobotov N. I. Sorokin A. A. Kamalov Non-invasive electromagnetic detection of prostate cancer: efficiency analysis Vestnik Urologii prostate cancer tissue resonance interaction prostate-specific antigen |
| title | Non-invasive electromagnetic detection of prostate cancer: efficiency analysis |
| title_full | Non-invasive electromagnetic detection of prostate cancer: efficiency analysis |
| title_fullStr | Non-invasive electromagnetic detection of prostate cancer: efficiency analysis |
| title_full_unstemmed | Non-invasive electromagnetic detection of prostate cancer: efficiency analysis |
| title_short | Non-invasive electromagnetic detection of prostate cancer: efficiency analysis |
| title_sort | non invasive electromagnetic detection of prostate cancer efficiency analysis |
| topic | prostate cancer tissue resonance interaction prostate-specific antigen |
| url | https://www.urovest.ru/jour/article/view/675 |
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