EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression

EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression

Summary: Triple-negative breast cancers (TNBCs) are frequently poorly differentiated with high propensity for metastasis. Enhancer of zeste homolog 2 (EZH2) is the lysine methyltransferase of polycomb repressive complex 2 that mediates transcriptional repression in normal cells and in cancer through...

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Bibliographic Details
Main Authors: Maria E. Gonzalez, Giuseppina Daniela Naimo, Talha Anwar, Alessandro Paolì, Shilpa R. Tekula, Suny Kim, Natasha Medhora, Shoshana A. Leflein, Jacob Itkin, Raymond Trievel, Kelley M. Kidwell, Yu-Chih Chen, Loredana Mauro, Euisik Yoon, Sebastiano Andò, Celina G. Kleer
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:iScience
Subjects:
Molecular biology
Epigenetics
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222010999

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http://www.sciencedirect.com/science/article/pii/S2589004222010999

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