Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19
Major findings of the pilot study involving 21 critically ill patients during the week after admission to the critical care unit specialized for COVID-19 are presented. Fourteen patients have recovered, while seven passed away. There were no differences between them in respect to clinical or laborat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/9/1341 |
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| author | Neven Žarković Biserka Orehovec Lidija Milković Bruno Baršić Franz Tatzber Willibald Wonisch Marko Tarle Marta Kmet Ana Mataić Antonia Jakovčević Tea Vuković Danijela Talić Georg Waeg Ivica Lukšić Elzbieta Skrzydlewska Kamelija Žarković |
| author_facet | Neven Žarković Biserka Orehovec Lidija Milković Bruno Baršić Franz Tatzber Willibald Wonisch Marko Tarle Marta Kmet Ana Mataić Antonia Jakovčević Tea Vuković Danijela Talić Georg Waeg Ivica Lukšić Elzbieta Skrzydlewska Kamelija Žarković |
| author_sort | Neven Žarković |
| collection | DOAJ |
| description | Major findings of the pilot study involving 21 critically ill patients during the week after admission to the critical care unit specialized for COVID-19 are presented. Fourteen patients have recovered, while seven passed away. There were no differences between them in respect to clinical or laboratory parameters monitored. However, protein adducts of the lipid peroxidation product 4-hydroxynonenal (HNE) were higher in the plasma of the deceased patients, while total antioxidant capacity was below the detection limit for the majority of sera samples in both groups. Moreover, levels of the HNE-protein adducts were constant in the plasma of the deceased patients, while in survivors, they have shown prominent and dynamic variations, suggesting that survivors had active oxidative stress response mechanisms reacting to COVID-19 aggression, which were not efficient in patients who died. Immunohistochemistry revealed the abundant presence of HNE-protein adducts in the lungs of deceased patients indicating that HNE is associated with the lethal outcome. It seems that HNE was spreading from the blood vessels more than being a consequence of pneumonia. Due to the limitations of the relatively small number of patients involved in this study, further research on HNE and antioxidants is needed. This might allow a better understanding of COVID-19 and options for utilizing antioxidants by personalized, integrative biomedicine approach to prevent the onset of HNE-mediated vitious circle of lipid peroxidation in patients with aggressive inflammatory diseases. |
| first_indexed | 2024-03-10T07:57:02Z |
| format | Article |
| id | doaj.art-5c9dfe67e0514dc28779b063c243c0c2 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T07:57:02Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-5c9dfe67e0514dc28779b063c243c0c22023-11-22T11:47:17ZengMDPI AGAntioxidants2076-39212021-08-01109134110.3390/antiox10091341Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19Neven Žarković0Biserka Orehovec1Lidija Milković2Bruno Baršić3Franz Tatzber4Willibald Wonisch5Marko Tarle6Marta Kmet7Ana Mataić8Antonia Jakovčević9Tea Vuković10Danijela Talić11Georg Waeg12Ivica Lukšić13Elzbieta Skrzydlewska14Kamelija Žarković15Laboratory for Oxidative Stress (LabOS), Ruđer Bošković Institute, 10000 Zagreb, CroatiaClinical Hospital Dubrava, 10000 Zagreb, CroatiaLaboratory for Oxidative Stress (LabOS), Ruđer Bošković Institute, 10000 Zagreb, CroatiaClinical Hospital Dubrava, 10000 Zagreb, CroatiaOmnignostica Ltd., 3421 Höflein an der Donau, AustriaOmnignostica Ltd., 3421 Höflein an der Donau, AustriaClinical Hospital Dubrava, 10000 Zagreb, CroatiaClinical Hospital Dubrava, 10000 Zagreb, CroatiaDepartment of Pathology, Clinical Hospital Centre Zagreb, 10000 Zagreb, CroatiaDepartment of Pathology, Clinical Hospital Centre Zagreb, 10000 Zagreb, CroatiaLaboratory for Oxidative Stress (LabOS), Ruđer Bošković Institute, 10000 Zagreb, CroatiaLaboratory for Oxidative Stress (LabOS), Ruđer Bošković Institute, 10000 Zagreb, CroatiaInstitute of Molecular Biosciences, Karl Franzens University, 8010 Graz, AustriaClinical Hospital Dubrava, 10000 Zagreb, CroatiaDepartment of Inorganic and Analytical Chemistry, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Pathology, Clinical Hospital Centre Zagreb, 10000 Zagreb, CroatiaMajor findings of the pilot study involving 21 critically ill patients during the week after admission to the critical care unit specialized for COVID-19 are presented. Fourteen patients have recovered, while seven passed away. There were no differences between them in respect to clinical or laboratory parameters monitored. However, protein adducts of the lipid peroxidation product 4-hydroxynonenal (HNE) were higher in the plasma of the deceased patients, while total antioxidant capacity was below the detection limit for the majority of sera samples in both groups. Moreover, levels of the HNE-protein adducts were constant in the plasma of the deceased patients, while in survivors, they have shown prominent and dynamic variations, suggesting that survivors had active oxidative stress response mechanisms reacting to COVID-19 aggression, which were not efficient in patients who died. Immunohistochemistry revealed the abundant presence of HNE-protein adducts in the lungs of deceased patients indicating that HNE is associated with the lethal outcome. It seems that HNE was spreading from the blood vessels more than being a consequence of pneumonia. Due to the limitations of the relatively small number of patients involved in this study, further research on HNE and antioxidants is needed. This might allow a better understanding of COVID-19 and options for utilizing antioxidants by personalized, integrative biomedicine approach to prevent the onset of HNE-mediated vitious circle of lipid peroxidation in patients with aggressive inflammatory diseases.https://www.mdpi.com/2076-3921/10/9/1341COVID-19oxidative stresslipid peroxidation4-hydroxynonenal (HNE)inflammationantioxidants |
| spellingShingle | Neven Žarković Biserka Orehovec Lidija Milković Bruno Baršić Franz Tatzber Willibald Wonisch Marko Tarle Marta Kmet Ana Mataić Antonia Jakovčević Tea Vuković Danijela Talić Georg Waeg Ivica Lukšić Elzbieta Skrzydlewska Kamelija Žarković Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19 Antioxidants COVID-19 oxidative stress lipid peroxidation 4-hydroxynonenal (HNE) inflammation antioxidants |
| title | Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19 |
| title_full | Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19 |
| title_fullStr | Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19 |
| title_full_unstemmed | Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19 |
| title_short | Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19 |
| title_sort | preliminary findings on the association of the lipid peroxidation product 4 hydroxynonenal with the lethal outcome of aggressive covid 19 |
| topic | COVID-19 oxidative stress lipid peroxidation 4-hydroxynonenal (HNE) inflammation antioxidants |
| url | https://www.mdpi.com/2076-3921/10/9/1341 |
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