INFLUENCE OF CURCUMIN ON CYTOKINES CONTENT AND ANGIOTENSIN-CONVERTING ACTIVITY UNDER INTRAHIPPOCAMPUS ADMINISTRATION OF β-AMYLOID PEPTIDE IN RATS
The purpose of this study was to investigate the effect of curcumin on cytokine response and angiotensin-converting activity in terms of intrahippocampus administration of ß-amyloid peptide in rats. Animals with experimental model of Alzheimer’s disease received nasal therapy aqueous solution of cur...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2015-08-01
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| Series: | Biotechnologia Acta |
| Subjects: | |
| Online Access: | http://biotechnology.kiev.ua/images/no3_2015/sokolik_3_2015.pdf |
| _version_ | 1797718217140994048 |
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| author | Sokolik V. V. Shulga S. M. |
| author_facet | Sokolik V. V. Shulga S. M. |
| author_sort | Sokolik V. V. |
| collection | DOAJ |
| description | The purpose of this study was to investigate the effect of curcumin on cytokine response and angiotensin-converting activity in terms of intrahippocampus administration of ß-amyloid peptide in rats. Animals with experimental model of Alzheimer’s disease received nasal therapy aqueous solution of curcumin. Recorded concentration of cytokines (interleukin-1ß, interleukin-6, interleukin-10, tumor necrosis factor-α) and angiotensin-converting activity in the parts of the brain (cerebral cortex and hippocampus) and blood serum, as well as indicators of conditional reflex escapers action. Install a reduction in cytokine response intrahippocampus administering Aß42_Human and angiotensin-converting activity inhibition in the brain but not in the blood serum of animals under the action of curcumin. Recorded improvement in cognitive performance in rats with a model of Alzheimer’s disease as a result of curcumin therapy. Nasal treatment with an aqueous solution of curcumin has anti-inflammatory effect in the targeted parts of the brain (сerebral cortex and hippocampus), but inhibits angiotensin-converting activity. |
| first_indexed | 2024-03-12T08:47:44Z |
| format | Article |
| id | doaj.art-5ca0262883a5450bb5d8cd7250795a2c |
| institution | Directory Open Access Journal |
| issn | 2410-7751 2410-776X |
| language | English |
| last_indexed | 2024-03-12T08:47:44Z |
| publishDate | 2015-08-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | Biotechnologia Acta |
| spelling | doaj.art-5ca0262883a5450bb5d8cd7250795a2c2023-09-02T16:24:47ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryBiotechnologia Acta2410-77512410-776X2015-08-0183788810.15407/biotech8.03.078INFLUENCE OF CURCUMIN ON CYTOKINES CONTENT AND ANGIOTENSIN-CONVERTING ACTIVITY UNDER INTRAHIPPOCAMPUS ADMINISTRATION OF β-AMYLOID PEPTIDE IN RATSSokolik V. V.0Shulga S. M.1State Institution “Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine”, KharkivState Institution “Institute for Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine”, KyivThe purpose of this study was to investigate the effect of curcumin on cytokine response and angiotensin-converting activity in terms of intrahippocampus administration of ß-amyloid peptide in rats. Animals with experimental model of Alzheimer’s disease received nasal therapy aqueous solution of curcumin. Recorded concentration of cytokines (interleukin-1ß, interleukin-6, interleukin-10, tumor necrosis factor-α) and angiotensin-converting activity in the parts of the brain (cerebral cortex and hippocampus) and blood serum, as well as indicators of conditional reflex escapers action. Install a reduction in cytokine response intrahippocampus administering Aß42_Human and angiotensin-converting activity inhibition in the brain but not in the blood serum of animals under the action of curcumin. Recorded improvement in cognitive performance in rats with a model of Alzheimer’s disease as a result of curcumin therapy. Nasal treatment with an aqueous solution of curcumin has anti-inflammatory effect in the targeted parts of the brain (сerebral cortex and hippocampus), but inhibits angiotensin-converting activity.http://biotechnology.kiev.ua/images/no3_2015/sokolik_3_2015.pdfcurcuminß-amyloid peptidecytokinesangiotensin-converting enzymeAlzheimer’s disease. |
| spellingShingle | Sokolik V. V. Shulga S. M. INFLUENCE OF CURCUMIN ON CYTOKINES CONTENT AND ANGIOTENSIN-CONVERTING ACTIVITY UNDER INTRAHIPPOCAMPUS ADMINISTRATION OF β-AMYLOID PEPTIDE IN RATS Biotechnologia Acta curcumin ß-amyloid peptide cytokines angiotensin-converting enzyme Alzheimer’s disease. |
| title | INFLUENCE OF CURCUMIN ON CYTOKINES CONTENT AND ANGIOTENSIN-CONVERTING ACTIVITY UNDER INTRAHIPPOCAMPUS ADMINISTRATION OF β-AMYLOID PEPTIDE IN RATS |
| title_full | INFLUENCE OF CURCUMIN ON CYTOKINES CONTENT AND ANGIOTENSIN-CONVERTING ACTIVITY UNDER INTRAHIPPOCAMPUS ADMINISTRATION OF β-AMYLOID PEPTIDE IN RATS |
| title_fullStr | INFLUENCE OF CURCUMIN ON CYTOKINES CONTENT AND ANGIOTENSIN-CONVERTING ACTIVITY UNDER INTRAHIPPOCAMPUS ADMINISTRATION OF β-AMYLOID PEPTIDE IN RATS |
| title_full_unstemmed | INFLUENCE OF CURCUMIN ON CYTOKINES CONTENT AND ANGIOTENSIN-CONVERTING ACTIVITY UNDER INTRAHIPPOCAMPUS ADMINISTRATION OF β-AMYLOID PEPTIDE IN RATS |
| title_short | INFLUENCE OF CURCUMIN ON CYTOKINES CONTENT AND ANGIOTENSIN-CONVERTING ACTIVITY UNDER INTRAHIPPOCAMPUS ADMINISTRATION OF β-AMYLOID PEPTIDE IN RATS |
| title_sort | influence of curcumin on cytokines content and angiotensin converting activity under intrahippocampus administration of β amyloid peptide in rats |
| topic | curcumin ß-amyloid peptide cytokines angiotensin-converting enzyme Alzheimer’s disease. |
| url | http://biotechnology.kiev.ua/images/no3_2015/sokolik_3_2015.pdf |
| work_keys_str_mv | AT sokolikvv influenceofcurcuminoncytokinescontentandangiotensinconvertingactivityunderintrahippocampusadministrationofbamyloidpeptideinrats AT shulgasm influenceofcurcuminoncytokinescontentandangiotensinconvertingactivityunderintrahippocampusadministrationofbamyloidpeptideinrats |