Renal malakoplakia presenting as a renal mass in a 55-year-old man: a case report
<p>Abstract</p> <p>Introduction</p> <p>Malakoplakia is an uncommon chronic inflammatory condition that has a gross and microscopic appearance resembling that of xanthogranulomatous pyelonephritis. It is characterized by distinctive Michaelis-Gutmann bodies. Malakoplakia...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-11-01
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| Series: | Journal of Medical Case Reports |
| Online Access: | http://www.jmedicalcasereports.com/content/6/1/379 |
| _version_ | 1818491963985362944 |
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| author | Abolhasani Maryam Jafari Azam Asgari Mojgan Salimi Hormoz |
| author_facet | Abolhasani Maryam Jafari Azam Asgari Mojgan Salimi Hormoz |
| author_sort | Abolhasani Maryam |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Introduction</p> <p>Malakoplakia is an uncommon chronic inflammatory condition that has a gross and microscopic appearance resembling that of xanthogranulomatous pyelonephritis. It is characterized by distinctive Michaelis-Gutmann bodies. Malakoplakia can affect any organ system but genitourinary tract involvement is the most common, particularly in immunocompromised individuals. Very rare cases have been reported to present as a unifocal lesion mimicking a renal tumor.</p> <p>Case presentation</p> <p>We report a case of renal malakoplakia in a 55-year-old Iranian man with a past history of recurrent urinary tract infections who presented with left flank pain. An ultrasound study showed a large solid left renal mass, and he underwent a left radical nephrectomy with a clinical diagnosis of a renal tumor. Pathology slides revealed the diffuse infiltration of sheets of Periodic Acid Schiff-positive histiocytes in his renal parenchyma; these cells showed strong immunoreactivity for CD 68. The final diagnosis was renal malakoplakia.</p> <p>Conclusion</p> <p>Renal malakoplakia must be kept in mind for patients presenting with a renal mass and a history of long-term recurrent renal infections or renal failure. The large, rapidly growing nodules of malakoplakia may mimic renal cell carcinoma in imaging studies. In these cases, a true cut needle biopsy may help the correct diagnosis and prevent unnecessary surgery.</p> |
| first_indexed | 2024-12-10T17:37:26Z |
| format | Article |
| id | doaj.art-5ca282ed0bc649e9b105efb0594e3807 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-10T17:37:26Z |
| publishDate | 2012-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-5ca282ed0bc649e9b105efb0594e38072022-12-22T01:39:29ZengBMCJournal of Medical Case Reports1752-19472012-11-016137910.1186/1752-1947-6-379Renal malakoplakia presenting as a renal mass in a 55-year-old man: a case reportAbolhasani MaryamJafari AzamAsgari MojganSalimi Hormoz<p>Abstract</p> <p>Introduction</p> <p>Malakoplakia is an uncommon chronic inflammatory condition that has a gross and microscopic appearance resembling that of xanthogranulomatous pyelonephritis. It is characterized by distinctive Michaelis-Gutmann bodies. Malakoplakia can affect any organ system but genitourinary tract involvement is the most common, particularly in immunocompromised individuals. Very rare cases have been reported to present as a unifocal lesion mimicking a renal tumor.</p> <p>Case presentation</p> <p>We report a case of renal malakoplakia in a 55-year-old Iranian man with a past history of recurrent urinary tract infections who presented with left flank pain. An ultrasound study showed a large solid left renal mass, and he underwent a left radical nephrectomy with a clinical diagnosis of a renal tumor. Pathology slides revealed the diffuse infiltration of sheets of Periodic Acid Schiff-positive histiocytes in his renal parenchyma; these cells showed strong immunoreactivity for CD 68. The final diagnosis was renal malakoplakia.</p> <p>Conclusion</p> <p>Renal malakoplakia must be kept in mind for patients presenting with a renal mass and a history of long-term recurrent renal infections or renal failure. The large, rapidly growing nodules of malakoplakia may mimic renal cell carcinoma in imaging studies. In these cases, a true cut needle biopsy may help the correct diagnosis and prevent unnecessary surgery.</p>http://www.jmedicalcasereports.com/content/6/1/379 |
| spellingShingle | Abolhasani Maryam Jafari Azam Asgari Mojgan Salimi Hormoz Renal malakoplakia presenting as a renal mass in a 55-year-old man: a case report Journal of Medical Case Reports |
| title | Renal malakoplakia presenting as a renal mass in a 55-year-old man: a case report |
| title_full | Renal malakoplakia presenting as a renal mass in a 55-year-old man: a case report |
| title_fullStr | Renal malakoplakia presenting as a renal mass in a 55-year-old man: a case report |
| title_full_unstemmed | Renal malakoplakia presenting as a renal mass in a 55-year-old man: a case report |
| title_short | Renal malakoplakia presenting as a renal mass in a 55-year-old man: a case report |
| title_sort | renal malakoplakia presenting as a renal mass in a 55 year old man a case report |
| url | http://www.jmedicalcasereports.com/content/6/1/379 |
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