Proton pump inhibitors and chronic kidney disease risk: a comparative study with histamine-2 receptor antagonists
Abstract This observational study explored the association between proton pump inhibitor (PPI) and histamine-2 receptor antagonist (H2RA) use and the risk of chronic kidney disease (CKD). Using the National Health Insurance Service-National Sample Cohort (NHIS-NSC) and six-hospital electronic health...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-48430-9 |
| _version_ | 1797415542951247872 |
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| author | Takhyeon Kweon Yerim Kim Kyung Joo Lee Won-Woo Seo Seung In Seo Woon Geon Shin Dong Ho Shin |
| author_facet | Takhyeon Kweon Yerim Kim Kyung Joo Lee Won-Woo Seo Seung In Seo Woon Geon Shin Dong Ho Shin |
| author_sort | Takhyeon Kweon |
| collection | DOAJ |
| description | Abstract This observational study explored the association between proton pump inhibitor (PPI) and histamine-2 receptor antagonist (H2RA) use and the risk of chronic kidney disease (CKD). Using the National Health Insurance Service-National Sample Cohort (NHIS-NSC) and six-hospital electronic health record (EHR) databases, CKD incidence was analyzed among PPI and H2RA users. Propensity score matching was used to balance baseline characteristics, with 1,869 subjects each in the PPI and H2RA groups from the NHIS-NSC, and 5,967 in EHR databases. CKD incidence was similar for both groups (5.72/1000 person-years vs. 7.57/1000 person-years; HR = 0.68; 95% CI, 0.35–1.30). A meta-analysis of the EHR databases showed no significant increased CKD risk associated with PPI use (HR = 1.03, 95% CI: 0.87–1.23). These results suggest PPI use may not increase CKD risk compared to H2RA use, but the potential role of PPI-induced CKD needs further research. Clinicians should consider this when prescribing long-term PPI therapy. |
| first_indexed | 2024-03-09T05:50:09Z |
| format | Article |
| id | doaj.art-5ca39b0d860541f4beed761a2d7fb233 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T05:50:09Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-5ca39b0d860541f4beed761a2d7fb2332023-12-03T12:17:36ZengNature PortfolioScientific Reports2045-23222023-12-0113111110.1038/s41598-023-48430-9Proton pump inhibitors and chronic kidney disease risk: a comparative study with histamine-2 receptor antagonistsTakhyeon Kweon0Yerim Kim1Kyung Joo Lee2Won-Woo Seo3Seung In Seo4Woon Geon Shin5Dong Ho Shin6Department of Internal Medicine, College of Medicine, Kangdong Sacred Heart Hospital, Hallym UniversityDepartment of Internal Medicine, College of Medicine, Kangdong Sacred Heart Hospital, Hallym UniversityDepartment of Internal Medicine, College of Medicine, Kangdong Sacred Heart Hospital, Hallym UniversityDepartment of Internal Medicine, College of Medicine, Kangdong Sacred Heart Hospital, Hallym UniversityDepartment of Internal Medicine, College of Medicine, Kangdong Sacred Heart Hospital, Hallym UniversityDepartment of Internal Medicine, College of Medicine, Kangdong Sacred Heart Hospital, Hallym UniversityDepartment of Internal Medicine, College of Medicine, Kangdong Sacred Heart Hospital, Hallym UniversityAbstract This observational study explored the association between proton pump inhibitor (PPI) and histamine-2 receptor antagonist (H2RA) use and the risk of chronic kidney disease (CKD). Using the National Health Insurance Service-National Sample Cohort (NHIS-NSC) and six-hospital electronic health record (EHR) databases, CKD incidence was analyzed among PPI and H2RA users. Propensity score matching was used to balance baseline characteristics, with 1,869 subjects each in the PPI and H2RA groups from the NHIS-NSC, and 5,967 in EHR databases. CKD incidence was similar for both groups (5.72/1000 person-years vs. 7.57/1000 person-years; HR = 0.68; 95% CI, 0.35–1.30). A meta-analysis of the EHR databases showed no significant increased CKD risk associated with PPI use (HR = 1.03, 95% CI: 0.87–1.23). These results suggest PPI use may not increase CKD risk compared to H2RA use, but the potential role of PPI-induced CKD needs further research. Clinicians should consider this when prescribing long-term PPI therapy.https://doi.org/10.1038/s41598-023-48430-9 |
| spellingShingle | Takhyeon Kweon Yerim Kim Kyung Joo Lee Won-Woo Seo Seung In Seo Woon Geon Shin Dong Ho Shin Proton pump inhibitors and chronic kidney disease risk: a comparative study with histamine-2 receptor antagonists Scientific Reports |
| title | Proton pump inhibitors and chronic kidney disease risk: a comparative study with histamine-2 receptor antagonists |
| title_full | Proton pump inhibitors and chronic kidney disease risk: a comparative study with histamine-2 receptor antagonists |
| title_fullStr | Proton pump inhibitors and chronic kidney disease risk: a comparative study with histamine-2 receptor antagonists |
| title_full_unstemmed | Proton pump inhibitors and chronic kidney disease risk: a comparative study with histamine-2 receptor antagonists |
| title_short | Proton pump inhibitors and chronic kidney disease risk: a comparative study with histamine-2 receptor antagonists |
| title_sort | proton pump inhibitors and chronic kidney disease risk a comparative study with histamine 2 receptor antagonists |
| url | https://doi.org/10.1038/s41598-023-48430-9 |
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