The Synergistic Antitumor Effect of Decitabine and Vorinostat Combination on HepG2 Human Hepatocellular Carcinoma Cell Line via Epigenetic Modulation of Autophagy–Apoptosis Molecular Crosstalk

The Synergistic Antitumor Effect of Decitabine and Vorinostat Combination on HepG2 Human Hepatocellular Carcinoma Cell Line via Epigenetic Modulation of Autophagy–Apoptosis Molecular Crosstalk

Hepatocellular carcinoma (HCC) is a worldwide health issue. Epigenetic alterations play a crucial role in HCC tumorigenesis. Using epigenetic modulators for HCC treatment confers a promising therapeutic effect. The aim of this study was to explore the effect of a decitabine (DAC) and vorinostat (VOR...

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Bibliographic Details
Main Authors: Basant M. Salama, Maged W. Helmy, Hosny Fouad, Marium M. Shamaa, Maha E. Houssen
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Current Issues in Molecular Biology
Subjects:
DNA methyltransferase inhibitors
decitabine
histone deacetylase inhibitors
vorinostat
apoptosis
autophagy
Online Access:https://www.mdpi.com/1467-3045/45/7/375

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